1L3L

Crystal structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001216	molecular_function	DNA-binding transcription activator activity
A	0003677	molecular_function	DNA binding
A	0006355	biological_process	regulation of DNA-templated transcription
A	0009372	biological_process	quorum sensing
A	0032993	cellular_component	protein-DNA complex
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001216	molecular_function	DNA-binding transcription activator activity
B	0003677	molecular_function	DNA binding
B	0006355	biological_process	regulation of DNA-templated transcription
B	0009372	biological_process	quorum sensing
B	0032993	cellular_component	protein-DNA complex
B	0045893	biological_process	positive regulation of DNA-templated transcription
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001216	molecular_function	DNA-binding transcription activator activity
C	0003677	molecular_function	DNA binding
C	0006355	biological_process	regulation of DNA-templated transcription
C	0009372	biological_process	quorum sensing
C	0032993	cellular_component	protein-DNA complex
C	0045893	biological_process	positive regulation of DNA-templated transcription
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001216	molecular_function	DNA-binding transcription activator activity
D	0003677	molecular_function	DNA binding
D	0006355	biological_process	regulation of DNA-templated transcription
D	0009372	biological_process	quorum sensing
D	0032993	cellular_component	protein-DNA complex
D	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LAE B 1001

Chain	Residue
B	ALA38
B	ALA105
B	MSE127
B	THR129
B	HOH1027
B	LEU40
B	TYR53
B	TRP57
B	TYR61
B	PHE62
B	ASP70
B	TRP85
B	PHE101

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE LAE D 1002

Chain	Residue
D	ALA38
D	LEU40
D	TYR53
D	TRP57
D	TYR61
D	PHE62
D	ASP70
D	VAL72
D	TRP85
D	PHE101
D	TYR102
D	ALA105
D	ILE110
D	MSE127
D	THR129
D	HOH1024

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LAE A 1003

Chain	Residue
A	ALA38
A	LEU40
A	TYR53
A	TRP57
A	TYR61
A	PHE62
A	ASP70
A	VAL72
A	TRP85
A	PHE101
A	TYR102
A	ALA105
A	MSE127
A	THR129
A	HOH1049

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE LAE C 1004

Chain	Residue
C	ALA38
C	LEU40
C	TYR53
C	TRP57
C	TYR61
C	PHE62
C	ASP70
C	TRP85
C	PHE101
C	TYR102
C	ALA105
C	MSE127
C	THR129
C	HOH1060

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00411

Chain	Residue	Details
A	MSE191-ARG210
B	MSE191-ARG210
C	MSE191-ARG210
D	MSE191-ARG210

---