Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1KYV

Lumazine Synthase from S.pombe bound to riboflavin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
A	0004746	molecular_function	riboflavin synthase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005758	cellular_component	mitochondrial intermembrane space
A	0009231	biological_process	riboflavin biosynthetic process
A	0009349	cellular_component	riboflavin synthase complex
A	0016740	molecular_function	transferase activity
A	1902444	molecular_function	riboflavin binding
B	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
B	0004746	molecular_function	riboflavin synthase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005758	cellular_component	mitochondrial intermembrane space
B	0009231	biological_process	riboflavin biosynthetic process
B	0009349	cellular_component	riboflavin synthase complex
B	0016740	molecular_function	transferase activity
B	1902444	molecular_function	riboflavin binding
C	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
C	0004746	molecular_function	riboflavin synthase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005758	cellular_component	mitochondrial intermembrane space
C	0009231	biological_process	riboflavin biosynthetic process
C	0009349	cellular_component	riboflavin synthase complex
C	0016740	molecular_function	transferase activity
C	1902444	molecular_function	riboflavin binding
D	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
D	0004746	molecular_function	riboflavin synthase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005758	cellular_component	mitochondrial intermembrane space
D	0009231	biological_process	riboflavin biosynthetic process
D	0009349	cellular_component	riboflavin synthase complex
D	0016740	molecular_function	transferase activity
D	1902444	molecular_function	riboflavin binding
E	0000906	molecular_function	6,7-dimethyl-8-ribityllumazine synthase activity
E	0004746	molecular_function	riboflavin synthase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005758	cellular_component	mitochondrial intermembrane space
E	0009231	biological_process	riboflavin biosynthetic process
E	0009349	cellular_component	riboflavin synthase complex
E	0016740	molecular_function	transferase activity
E	1902444	molecular_function	riboflavin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 1001

Chain	Residue
A	ARG133
B	GLY90
B	SER91
B	THR92
B	RBF502
B	HOH1005
B	HOH1014

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 E 1002

Chain	Residue
E	SER91
E	THR92
E	HIS94
E	RBF505
E	HOH1003
D	ARG133
E	GLY90

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 1003

Chain	Residue
B	ARG133
C	GLY90
C	SER91
C	THR92
C	RBF503
C	HOH1004
C	HOH1024

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 1004

Chain	Residue
A	GLY90
A	SER91
A	THR92
A	RBF501
E	ARG133

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 D 1005

Chain	Residue
C	ARG133
D	GLY90
D	SER91
D	THR92
D	RBF504
D	HOH1006

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE RBF A 501

Chain	Residue
A	TRP27
A	GLY61
A	SER62
A	TRP63
A	GLU64
A	VAL86
A	LEU87
A	ILE88
A	HIS94
A	ILE98
A	PO41004
A	HOH1005
E	ILE118
E	LEU119
E	HIS142

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE RBF B 502

Chain	Residue
A	ILE118
A	LEU119
A	HIS142
A	TRP146
B	TRP27
B	GLY61
B	SER62
B	TRP63
B	GLU64
B	VAL86
B	LEU87
B	ILE88
B	HIS94
B	PO41001
B	HOH1004

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE RBF C 503

Chain	Residue
B	ILE118
B	LEU119
B	HIS142
C	TRP27
C	GLY61
C	SER62
C	TRP63
C	GLU64
C	VAL86
C	LEU87
C	ILE88
C	HIS94
C	PO41003
C	HOH1005
C	HOH1024

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE RBF D 504

Chain	Residue
C	ILE118
C	LEU119
C	HIS142
C	TRP146
D	TRP27
D	GLY61
D	SER62
D	TRP63
D	GLU64
D	VAL86
D	LEU87
D	ILE88
D	HIS94
D	ILE98
D	PO41005
D	HOH1007

site_id	BC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE RBF E 505

Chain	Residue
E	SER62
E	TRP63
E	GLU64
E	VAL86
E	LEU87
E	ILE88
E	HIS94
E	PO41002
E	HOH1005
D	ILE118
D	LEU119
D	HIS142
D	TRP146
E	TRP27
E	GLY61

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	ACT_SITE: Proton donor => ECO:0000255

Chain	Residue	Details
A	HIS94
B	HIS94
C	HIS94
D	HIS94
E	HIS94

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING:

Chain	Residue	Details
A	TRP27
B	SER62
B	VAL86
B	LEU119
C	TRP27
C	SER62
C	VAL86
C	LEU119
D	TRP27
D	SER62
D	VAL86
D	LEU119
E	TRP27
E	SER62
E	VAL86
E	LEU119
A	SER62
A	VAL86
A	LEU119
B	TRP27

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
C	ARG133
D	SER91
D	ARG133
E	SER91
E	ARG133
A	SER91
A	ARG133
B	SER91
B	ARG133
C	SER91

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)