1KVK

The Structure of Binary complex between a Mammalian Mevalonate Kinase and ATP: Insights into the Reaction Mechanism and Human Inherited Disease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003729	molecular_function	mRNA binding
A	0004496	molecular_function	mevalonate kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006695	biological_process	cholesterol biosynthetic process
A	0006720	biological_process	isoprenoid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
A	0016125	biological_process	sterol metabolic process
A	0016126	biological_process	sterol biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0017148	biological_process	negative regulation of translation
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
A	0033386	biological_process	geranylgeranyl diphosphate biosynthetic process
A	0033489	biological_process	cholesterol biosynthetic process via desmosterol
A	0033490	biological_process	cholesterol biosynthetic process via lathosterol
A	0036197	biological_process	zymosterol biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0045540	biological_process	regulation of cholesterol biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0050728	biological_process	negative regulation of inflammatory response
A	1990825	molecular_function	sequence-specific mRNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 536

Chain	Residue
A	GLY144
A	SER146
A	ALA147
A	GLU193
A	HIS197
A	ASP204
A	ATP535

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP A 535

Chain	Residue
A	ASN104
A	GLU105
A	SER108
A	SER135
A	GLY140
A	GLY142
A	GLY144
A	SER145
A	SER146
A	ILE196
A	HIS197
A	ASP204
A	MG536
A	HOH1020
A	HOH1035
A	HOH1064
A	LYS13
A	ASN55

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Functional Information from PROSITE/UniProt

site_id	PS00627
Number of Residues	12
Details	GHMP_KINASES_ATP GHMP kinases putative ATP-binding domain. LPpGaGLGSSAA

Chain	Residue	Details
A	LEU137-ALA148

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q03426","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q03426","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11877411","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KVK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11877411","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	THR243

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