1KSJ
Complex of Arl2 and PDE delta, Crystal Form 2 (SeMet)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005813 | cellular_component | centrosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006110 | biological_process | regulation of glycolytic process |
| A | 0006457 | biological_process | protein folding |
| A | 0007098 | biological_process | centrosome cycle |
| A | 0010811 | biological_process | positive regulation of cell-substrate adhesion |
| A | 0015630 | cellular_component | microtubule cytoskeleton |
| A | 0015870 | biological_process | acetylcholine transport |
| A | 0016328 | cellular_component | lateral plasma membrane |
| A | 0019003 | molecular_function | GDP binding |
| A | 0031113 | biological_process | regulation of microtubule polymerization |
| A | 0031116 | biological_process | positive regulation of microtubule polymerization |
| A | 0034260 | biological_process | negative regulation of GTPase activity |
| A | 0051457 | biological_process | maintenance of protein location in nucleus |
| A | 0070830 | biological_process | bicellular tight junction assembly |
| A | 1903715 | biological_process | regulation of aerobic respiration |
| B | 0005095 | molecular_function | GTPase inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005856 | cellular_component | cytoskeleton |
| B | 0005929 | cellular_component | cilium |
| B | 0007601 | biological_process | visual perception |
| B | 0016020 | cellular_component | membrane |
| B | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0042995 | cellular_component | cell projection |
| B | 0050953 | biological_process | sensory perception of light stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 A 202 |
| Chain | Residue |
| A | ASN26 |
| A | LYS29 |
| A | THR47 |
| A | GLY69 |
| A | GDP201 |
| A | MG205 |
| A | HOH239 |
| A | HOH240 |
| A | HOH245 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 205 |
| Chain | Residue |
| A | THR30 |
| A | THR47 |
| A | GDP201 |
| A | PO4202 |
| A | GTP203 |
| A | HOH239 |
| A | HOH240 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BME A 236 |
| Chain | Residue |
| A | LEU24 |
| A | VAL91 |
| A | ASP92 |
| A | ASP95 |
| A | MSE99 |
| A | CYS102 |
| A | HOH247 |
| A | HOH248 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP A 201 |
| Chain | Residue |
| A | LEU24 |
| A | ASP25 |
| A | ASN26 |
| A | ALA27 |
| A | GLY28 |
| A | LYS29 |
| A | THR30 |
| A | THR31 |
| A | ILE44 |
| A | ASN125 |
| A | LYS126 |
| A | ASP128 |
| A | SER158 |
| A | ALA159 |
| A | VAL160 |
| A | PO4202 |
| A | MG205 |
| A | HOH239 |
| A | HOH240 |
| A | HOH266 |
| B | GLY84 |
| B | CME86 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GTP A 203 |
| Chain | Residue |
| A | ASP25 |
| A | ASN26 |
| A | ALA27 |
| A | GLY28 |
| A | LYS29 |
| A | THR30 |
| A | THR31 |
| A | ILE44 |
| A | PRO46 |
| A | THR47 |
| A | GLY69 |
| A | ASN125 |
| A | LYS126 |
| A | ASP128 |
| A | LEU129 |
| A | SER158 |
| A | ALA159 |
| A | VAL160 |
| A | MG205 |
| A | HOH239 |
| A | HOH240 |
| A | HOH245 |
| B | TYR81 |
| B | GLY84 |
| B | CME86 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11980706 |
| Chain | Residue | Details |
| A | GLY23 | |
| A | ASP66 | |
| A | GLY68 | |
| A | ASN125 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | SER45 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: N-myristoyl glycine => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P36404 |
| Chain | Residue | Details |
| A | LYS71 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11980706 |
| Chain | Residue | Details |
| A | GLN70 |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 628 |
| Chain | Residue | Details |
| A | GLN70 | electrostatic stabiliser |
