1KSH

Complex of Arl2 and PDE delta, Crystal Form 2 (native)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005813	cellular_component	centrosome
A	0005856	cellular_component	cytoskeleton
A	0006110	biological_process	regulation of glycolytic process
A	0006457	biological_process	protein folding
A	0007098	biological_process	centrosome cycle
A	0010811	biological_process	positive regulation of cell-substrate adhesion
A	0015630	cellular_component	microtubule cytoskeleton
A	0016328	cellular_component	lateral plasma membrane
A	0019003	molecular_function	GDP binding
A	0031113	biological_process	regulation of microtubule polymerization
A	0031116	biological_process	positive regulation of microtubule polymerization
A	0034260	biological_process	negative regulation of GTPase activity
A	0036064	cellular_component	ciliary basal body
A	0051457	biological_process	maintenance of protein location in nucleus
A	0070830	biological_process	bicellular tight junction assembly
A	1903715	biological_process	regulation of aerobic respiration
B	0005095	molecular_function	GTPase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005929	cellular_component	cilium
B	0007601	biological_process	visual perception
B	0016020	cellular_component	membrane
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031267	molecular_function	small GTPase binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0042995	cellular_component	cell projection
B	0050953	biological_process	sensory perception of light stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	THR30
A	THR47
A	GDP201
A	PO4203
A	HOH205
A	HOH206

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 203

Chain	Residue
A	THR47
A	GLY68
A	GLY69
A	GDP201
A	MG202
A	HOH205
A	ASP25
A	ASN26
A	LYS29

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP A 201

Chain	Residue
A	ASP25
A	ASN26
A	ALA27
A	GLY28
A	LYS29
A	THR30
A	THR31
A	ILE44
A	ASN125
A	LYS126
A	ASP128
A	LEU129
A	SER158
A	ALA159
A	VAL160
A	MG202
A	PO4203
A	HOH205
A	HOH206
A	HOH210
A	HOH236
B	GLY84
B	GLN85
B	CME86

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11980706","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P36404","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN70

---

site_id	MCSA1
Number of Residues	1
Details	M-CSA 628

Chain	Residue	Details
A	GLN70	electrostatic stabiliser

---