1KR5
Crystal structure of human L-isoaspartyl methyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004719 | molecular_function | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006479 | biological_process | protein methylation |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030091 | biological_process | protein repair |
| A | 0032259 | biological_process | methylation |
| A | 0036211 | biological_process | protein modification process |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1903561 | cellular_component | extracellular vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE SAH A 300 |
| Chain | Residue |
| A | ALA56 |
| A | ASP109 |
| A | HIS110 |
| A | LEU114 |
| A | GLY140 |
| A | ASP141 |
| A | GLY142 |
| A | ARG143 |
| A | GLY158 |
| A | PRO214 |
| A | LEU215 |
| A | THR57 |
| A | THR216 |
| A | GLN221 |
| A | HOH301 |
| A | HOH304 |
| A | ILE58 |
| A | SER59 |
| A | HIS64 |
| A | GLY85 |
| A | SER86 |
| A | GLY87 |
| A | SER88 |
Functional Information from PROSITE/UniProt
| site_id | PS01279 |
| Number of Residues | 16 |
| Details | PCMT Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. GDGrmGYaeeAPYDaI |
| Chain | Residue | Details |
| A | GLY140-ILE155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"Q27869","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11792715","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11847284","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1I1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KR5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
