Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1KQO

Crystal structure of NMN/NaMN adenylyltransferase complexed with deamido-NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
A	0000785	cellular_component	chromatin
A	0003824	molecular_function	catalytic activity
A	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006163	biological_process	purine nucleotide metabolic process
A	0006769	biological_process	nicotinamide metabolic process
A	0009058	biological_process	biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0009435	biological_process	NAD+ biosynthetic process
A	0009611	biological_process	response to wounding
A	0016604	cellular_component	nuclear body
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0042802	molecular_function	identical protein binding
A	0043410	biological_process	positive regulation of MAPK cascade
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
A	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
A	1904178	biological_process	negative regulation of adipose tissue development
A	1904179	biological_process	positive regulation of adipose tissue development
A	1990966	biological_process	ATP generation from poly-ADP-D-ribose
B	0000166	molecular_function	nucleotide binding
B	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
B	0000785	cellular_component	chromatin
B	0003824	molecular_function	catalytic activity
B	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006163	biological_process	purine nucleotide metabolic process
B	0006769	biological_process	nicotinamide metabolic process
B	0009058	biological_process	biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0009435	biological_process	NAD+ biosynthetic process
B	0009611	biological_process	response to wounding
B	0016604	cellular_component	nuclear body
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0042802	molecular_function	identical protein binding
B	0043410	biological_process	positive regulation of MAPK cascade
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
B	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
B	1904178	biological_process	negative regulation of adipose tissue development
B	1904179	biological_process	positive regulation of adipose tissue development
B	1990966	biological_process	ATP generation from poly-ADP-D-ribose
C	0000166	molecular_function	nucleotide binding
C	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
C	0000785	cellular_component	chromatin
C	0003824	molecular_function	catalytic activity
C	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0006163	biological_process	purine nucleotide metabolic process
C	0006769	biological_process	nicotinamide metabolic process
C	0009058	biological_process	biosynthetic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0009435	biological_process	NAD+ biosynthetic process
C	0009611	biological_process	response to wounding
C	0016604	cellular_component	nuclear body
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
C	0042802	molecular_function	identical protein binding
C	0043410	biological_process	positive regulation of MAPK cascade
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
C	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
C	1904178	biological_process	negative regulation of adipose tissue development
C	1904179	biological_process	positive regulation of adipose tissue development
C	1990966	biological_process	ATP generation from poly-ADP-D-ribose
D	0000166	molecular_function	nucleotide binding
D	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
D	0000785	cellular_component	chromatin
D	0003824	molecular_function	catalytic activity
D	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006163	biological_process	purine nucleotide metabolic process
D	0006769	biological_process	nicotinamide metabolic process
D	0009058	biological_process	biosynthetic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0009435	biological_process	NAD+ biosynthetic process
D	0009611	biological_process	response to wounding
D	0016604	cellular_component	nuclear body
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
D	0042802	molecular_function	identical protein binding
D	0043410	biological_process	positive regulation of MAPK cascade
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
D	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
D	1904178	biological_process	negative regulation of adipose tissue development
D	1904179	biological_process	positive regulation of adipose tissue development
D	1990966	biological_process	ATP generation from poly-ADP-D-ribose
E	0000166	molecular_function	nucleotide binding
E	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
E	0000785	cellular_component	chromatin
E	0003824	molecular_function	catalytic activity
E	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0006163	biological_process	purine nucleotide metabolic process
E	0006769	biological_process	nicotinamide metabolic process
E	0009058	biological_process	biosynthetic process
E	0009165	biological_process	nucleotide biosynthetic process
E	0009435	biological_process	NAD+ biosynthetic process
E	0009611	biological_process	response to wounding
E	0016604	cellular_component	nuclear body
E	0016740	molecular_function	transferase activity
E	0016779	molecular_function	nucleotidyltransferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
E	0042802	molecular_function	identical protein binding
E	0043410	biological_process	positive regulation of MAPK cascade
E	0043524	biological_process	negative regulation of neuron apoptotic process
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
E	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
E	1904178	biological_process	negative regulation of adipose tissue development
E	1904179	biological_process	positive regulation of adipose tissue development
E	1990966	biological_process	ATP generation from poly-ADP-D-ribose
F	0000166	molecular_function	nucleotide binding
F	0000309	molecular_function	nicotinamide-nucleotide adenylyltransferase activity
F	0000785	cellular_component	chromatin
F	0003824	molecular_function	catalytic activity
F	0004515	molecular_function	nicotinate-nucleotide adenylyltransferase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0006163	biological_process	purine nucleotide metabolic process
F	0006769	biological_process	nicotinamide metabolic process
F	0009058	biological_process	biosynthetic process
F	0009165	biological_process	nucleotide biosynthetic process
F	0009435	biological_process	NAD+ biosynthetic process
F	0009611	biological_process	response to wounding
F	0016604	cellular_component	nuclear body
F	0016740	molecular_function	transferase activity
F	0016779	molecular_function	nucleotidyltransferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
F	0042802	molecular_function	identical protein binding
F	0043410	biological_process	positive regulation of MAPK cascade
F	0043524	biological_process	negative regulation of neuron apoptotic process
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	0140768	molecular_function	protein ADP-ribosyltransferase-substrate adaptor activity
F	1902511	biological_process	negative regulation of apoptotic DNA fragmentation
F	1904178	biological_process	negative regulation of adipose tissue development
F	1904179	biological_process	positive regulation of adipose tissue development
F	1990966	biological_process	ATP generation from poly-ADP-D-ribose

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE DND A 301

Chain	Residue
A	CYS14
A	GLU94
A	THR95
A	CYS155
A	GLY156
A	LEU159
A	LEU168
A	TRP169
A	GLU215
A	HOH401
A	HOH403
A	GLY15
A	HOH404
A	HOH405
A	HOH408
A	HOH418
A	HOH438
A	HOH482
A	SER16
A	PHE17
A	MET23
A	LEU27
A	TYR55
A	LYS57
A	TRP92

site_id	AC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE DND B 301

Chain	Residue
B	CYS14
B	GLY15
B	SER16
B	PHE17
B	MET23
B	HIS24
B	LEU27
B	VAL51
B	TYR55
B	LYS57
B	TRP92
B	GLU94
B	THR95
B	CYS155
B	GLY156
B	ASP158
B	LEU159
B	LEU168
B	TRP169
B	VAL186
B	GLU215
B	HOH402
B	HOH405
B	HOH406
B	HOH420
B	HOH445
B	HOH450
B	HOH453
B	HOH455

site_id	AC3
Number of Residues	28
Details	BINDING SITE FOR RESIDUE DND C 301

Chain	Residue
C	CYS14
C	GLY15
C	SER16
C	PHE17
C	MET23
C	HIS24
C	LEU27
C	VAL51
C	TYR55
C	LYS57
C	TRP92
C	GLU94
C	THR95
C	CYS155
C	GLY156
C	LEU159
C	LEU168
C	TRP169
C	GLU215
C	HOH401
C	HOH405
C	HOH410
C	HOH422
C	HOH450
C	HOH456
C	HOH462
C	HOH473
C	HOH477

site_id	AC4
Number of Residues	29
Details	BINDING SITE FOR RESIDUE DND D 301

Chain	Residue
D	TRP169
D	VAL186
D	GLU215
D	ASP220
D	HOH401
D	HOH403
D	HOH404
D	HOH413
D	HOH415
D	HOH419
D	HOH422
D	HOH435
D	CYS14
D	GLY15
D	SER16
D	PHE17
D	MET23
D	HIS24
D	LEU27
D	VAL51
D	TYR55
D	LYS57
D	TRP92
D	GLU94
D	THR95
D	CYS155
D	GLY156
D	LEU159
D	LEU168

site_id	AC5
Number of Residues	31
Details	BINDING SITE FOR RESIDUE DND E 301

Chain	Residue
E	CYS14
E	GLY15
E	SER16
E	PHE17
E	MET23
E	HIS24
E	LEU27
E	VAL51
E	TYR55
E	LYS57
E	TRP92
E	GLU94
E	THR95
E	CYS155
E	GLY156
E	ASP158
E	LEU159
E	LEU168
E	TRP169
E	VAL186
E	GLU215
E	HOH402
E	HOH404
E	HOH405
E	HOH406
E	HOH416
E	HOH428
E	HOH435
E	HOH436
E	HOH441
E	HOH442

site_id	AC6
Number of Residues	27
Details	BINDING SITE FOR RESIDUE DND F 301

Chain	Residue
F	CYS14
F	GLY15
F	SER16
F	PHE17
F	MET23
F	HIS24
F	LEU27
F	VAL51
F	TYR55
F	LYS57
F	TRP92
F	GLU94
F	THR95
F	CYS155
F	GLY156
F	ASP158
F	LEU159
F	LEU168
F	TRP169
F	GLU215
F	HOH401
F	HOH403
F	HOH404
F	HOH407
F	HOH409
F	HOH415
F	HOH422

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	BINDING: BINDING => ECO:0000269\|PubMed:11788603, ECO:0007744\|PDB:1KQN

Chain	Residue	Details
A	GLY15
A	LEU168
A	TRP169
A	GLU215
A	ASN219
B	GLY15
B	SER16
B	PHE17
B	MET23
B	LYS57
B	TRP92
A	SER16
B	THR95
B	GLY156
B	ASP158
B	LEU168
B	TRP169
B	GLU215
B	ASN219
C	GLY15
C	SER16
C	PHE17
A	PHE17
C	MET23
C	LYS57
C	TRP92
C	THR95
C	GLY156
C	ASP158
C	LEU168
C	TRP169
C	GLU215
C	ASN219
A	MET23
D	GLY15
D	SER16
D	PHE17
D	MET23
D	LYS57
D	TRP92
D	THR95
D	GLY156
D	ASP158
D	LEU168
A	LYS57
D	TRP169
D	GLU215
D	ASN219
E	GLY15
E	SER16
E	PHE17
E	MET23
E	LYS57
E	TRP92
E	THR95
A	TRP92
E	GLY156
E	ASP158
E	LEU168
E	TRP169
E	GLU215
E	ASN219
F	GLY15
F	SER16
F	PHE17
F	MET23
A	THR95
F	LYS57
F	TRP92
F	THR95
F	GLY156
F	ASP158
F	LEU168
F	TRP169
F	GLU215
F	ASN219
A	GLY156
A	ASP158

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q96T66

Chain	Residue	Details
A	HIS24
D	HIS24
D	LYS58
D	THR224
E	HIS24
E	LYS58
E	THR224
F	HIS24
F	LYS58
F	THR224
A	LYS58
A	THR224
B	HIS24
B	LYS58
B	THR224
C	HIS24
C	LYS58
C	THR224

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:11959140, ECO:0007744\|PDB:1GZU

Chain	Residue	Details
A	TYR55
B	TYR55
C	TYR55
D	TYR55
E	TYR55
F	TYR55

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER117
B	SER117
C	SER117
D	SER117
E	SER117
F	SER117

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR119
B	THR119
C	THR119
D	THR119
E	THR119
F	THR119

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)