1KPL
Crystal Structure of the ClC Chloride Channel from S. typhimurium
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005247 | molecular_function | voltage-gated chloride channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006821 | biological_process | chloride transport |
| A | 0015108 | molecular_function | chloride transmembrane transporter activity |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 1902476 | biological_process | chloride transmembrane transport |
| B | 0005247 | molecular_function | voltage-gated chloride channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006821 | biological_process | chloride transport |
| B | 0015108 | molecular_function | chloride transmembrane transporter activity |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 1902476 | biological_process | chloride transmembrane transport |
| C | 0005247 | molecular_function | voltage-gated chloride channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006821 | biological_process | chloride transport |
| C | 0015108 | molecular_function | chloride transmembrane transporter activity |
| C | 0015297 | molecular_function | antiporter activity |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| C | 1902476 | biological_process | chloride transmembrane transport |
| D | 0005247 | molecular_function | voltage-gated chloride channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006821 | biological_process | chloride transport |
| D | 0015108 | molecular_function | chloride transmembrane transporter activity |
| D | 0015297 | molecular_function | antiporter activity |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
| D | 1902476 | biological_process | chloride transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 503 |
| Chain | Residue |
| A | SER107 |
| A | GLY355 |
| A | ILE356 |
| A | PHE357 |
| A | TYR445 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 504 |
| Chain | Residue |
| B | TYR445 |
| B | SER107 |
| B | GLY355 |
| B | ILE356 |
| B | PHE357 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 505 |
| Chain | Residue |
| A | ARG209 |
| B | ARG17 |
| D | MET168 |
| D | ARG169 |
| D | SER170 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 506 |
| Chain | Residue |
| A | ARG205 |
| A | ARG209 |
| A | ASN211 |
| A | LEU212 |
| A | ILE213 |
| B | ARG205 |
| B | ARG209 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL C 603 |
| Chain | Residue |
| C | SER107 |
| C | GLY355 |
| C | ILE356 |
| C | PHE357 |
| C | TYR445 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL D 604 |
| Chain | Residue |
| D | SER107 |
| D | GLY355 |
| D | ILE356 |
| D | PHE357 |
| D | TYR445 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 605 |
| Chain | Residue |
| B | MET168 |
| B | ARG169 |
| B | SER170 |
| C | ARG209 |
| D | ARG17 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 606 |
| Chain | Residue |
| C | ARG205 |
| C | ARG209 |
| C | ASN211 |
| C | LEU212 |
| C | ILE213 |
| D | ARG205 |
| D | ARG209 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MYS B 501 |
| Chain | Residue |
| A | ILE227 |
| B | LEU256 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MYS D 601 |
| Chain | Residue |
| C | ILE227 |
| D | LEU256 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 868 |
| Details | Transmembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 208 |
| Details | Topological domain: {"description":"Periplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 208 |
| Details | Intramembrane: {"description":"Helical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 144 |
| Details | Topological domain: {"description":"Cytoplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 32 |
| Details | Intramembrane: {"description":"Note=Loop between two helices"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Selectivity filter part_1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Selectivity filter part_2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Selectivity filter part_3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Site: {"description":"Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Site: {"description":"Mediates proton transfer from the protein to the inner aqueous phase"} |
| Chain | Residue | Details |
