1KOL
Crystal structure of formaldehyde dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0018467 | molecular_function | formaldehyde dehydrogenase activity |
| A | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047895 | molecular_function | formaldehyde dismutase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0018467 | molecular_function | formaldehyde dehydrogenase activity |
| B | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047895 | molecular_function | formaldehyde dismutase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | CYS46 |
| A | HIS67 |
| A | ASP169 |
| A | NAD1403 |
| A | HOH1404 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1002 |
| Chain | Residue |
| A | CYS97 |
| A | CYS100 |
| A | CYS103 |
| A | CYS111 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 1003 |
| Chain | Residue |
| B | CYS46 |
| B | HIS67 |
| B | ASP169 |
| B | NAD2403 |
| B | HOH2404 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1004 |
| Chain | Residue |
| B | CYS97 |
| B | CYS100 |
| B | CYS103 |
| B | CYS111 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1003 |
| Chain | Residue |
| A | PRO241 |
| A | LEU242 |
| A | HIS269 |
| A | HOH1548 |
| A | HOH1618 |
| A | HOH1634 |
| A | HOH1735 |
| A | HOH1836 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1002 |
| Chain | Residue |
| B | PRO241 |
| B | LEU242 |
| B | HIS269 |
| B | HOH2656 |
| B | HOH2667 |
| B | HOH2718 |
| B | HOH2846 |
| site_id | AC7 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAD A 1403 |
| Chain | Residue |
| A | GLY47 |
| A | SER48 |
| A | GLN50 |
| A | HIS51 |
| A | PHE93 |
| A | ASP169 |
| A | THR173 |
| A | GLY193 |
| A | GLY195 |
| A | PRO196 |
| A | VAL197 |
| A | GLY216 |
| A | ASP217 |
| A | LEU218 |
| A | ARG222 |
| A | ALA261 |
| A | VAL262 |
| A | ALA266 |
| A | ARG267 |
| A | HIS269 |
| A | VAL282 |
| A | PRO299 |
| A | LEU301 |
| A | TRP327 |
| A | GLY336 |
| A | GLN337 |
| A | THR338 |
| A | PHE379 |
| A | ZN1001 |
| A | HOH1409 |
| A | HOH1415 |
| A | HOH1426 |
| A | HOH1450 |
| A | HOH1467 |
| A | HOH1579 |
| site_id | AC8 |
| Number of Residues | 40 |
| Details | BINDING SITE FOR RESIDUE NAD B 2403 |
| Chain | Residue |
| B | HOH2422 |
| B | HOH2425 |
| B | HOH2427 |
| B | HOH2482 |
| B | HOH2490 |
| B | HOH2503 |
| B | HOH2602 |
| B | HOH2670 |
| B | HOH2691 |
| B | GLY47 |
| B | SER48 |
| B | GLN50 |
| B | HIS51 |
| B | PHE93 |
| B | ASP169 |
| B | THR173 |
| B | GLY193 |
| B | GLY195 |
| B | PRO196 |
| B | VAL197 |
| B | GLY216 |
| B | ASP217 |
| B | LEU218 |
| B | ARG222 |
| B | LEU236 |
| B | ALA261 |
| B | VAL262 |
| B | ALA266 |
| B | ARG267 |
| B | HIS269 |
| B | VAL282 |
| B | PRO299 |
| B | LEU301 |
| B | TRP327 |
| B | GLY336 |
| B | GLN337 |
| B | THR338 |
| B | PHE379 |
| B | ZN1003 |
| B | HOH2404 |
Functional Information from PROSITE/UniProt
| site_id | PS00059 |
| Number of Residues | 15 |
| Details | ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEiTGEviekGrdV |
| Chain | Residue | Details |
| A | GLY66-VAL80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12445786, ECO:0007744|PDB:1KOL |
| Chain | Residue | Details |
| A | GLY47 | |
| A | LEU112 | |
| A | GLY198 | |
| A | LEU218 | |
| A | LEU223 | |
| A | GLY263 | |
| A | GLY268 | |
| A | GLY300 | |
| A | GLN337 | |
| B | GLY47 | |
| B | SER48 | |
| B | GLU68 | |
| B | GLY98 | |
| B | ARG101 | |
| B | LYS104 | |
| B | LEU112 | |
| B | GLY198 | |
| B | LEU218 | |
| B | LEU223 | |
| B | GLY263 | |
| B | GLY268 | |
| B | GLY300 | |
| B | GLN337 | |
| A | SER48 | |
| A | GLU68 | |
| A | GLY98 | |
| A | ARG101 | |
| A | LYS104 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1KOL |
| Chain | Residue | Details |
| A | ILE170 | |
| B | ILE170 |
