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CRYSTAL STRUCTURE OF THE COMPLEX OF A CATALYTIC ANTIBODY FAB WITH A TRANSITION STATE ANALOG: STRUCTURAL SIMILARITIES IN ESTERASE-LIKE ABZYMES

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0030183biological_processB cell differentiation
A0042105cellular_componentalpha-beta T cell receptor complex
A0071735cellular_componentIgG immunoglobulin complex
C0002250biological_processadaptive immune response
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005886cellular_componentplasma membrane
C0030183biological_processB cell differentiation
C0042105cellular_componentalpha-beta T cell receptor complex
C0071735cellular_componentIgG immunoglobulin complex
E0002250biological_processadaptive immune response
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005886cellular_componentplasma membrane
E0030183biological_processB cell differentiation
E0042105cellular_componentalpha-beta T cell receptor complex
E0071735cellular_componentIgG immunoglobulin complex
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN A 215
ChainResidue
AGLU79
EGLU79
EGLU81

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE PNP B 551
ChainResidue
BGLY99
BASP100
BTYR101
BTYR102
BTRP109
ALEU89
ATYR91
ATYR96
BHIS35
BVAL37
BTRP47

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PNP D 552
ChainResidue
CLEU89
CTYR91
DHIS35
DVAL37
DTRP47
DGLY99
DASP100
DTYR101
DTYR102
DTRP109

site_idAC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE PNP F 553
ChainResidue
ETYR91
ETYR96
FHIS35
FVAL37
FTRP47
FGLY99
FASP100
FTYR101
FTYR102
FTRP109

Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
ATYR192-HIS198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues291
DetailsDomain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues276
DetailsDomain: {"description":"Ig-like 1"}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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