1KK1

Structure of the large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi-G235D mutant complexed with GDPNP-Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 411

Chain	Residue
A	CYS60
A	CYS63
A	CYS72
A	CYS75

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 413

Chain	Residue
A	THR24
A	GNP412
A	HOH1024
A	HOH1032
A	HOH1038

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GNP A 412

Chain	Residue
A	VAL19
A	ASP20
A	HIS21
A	GLY22
A	LYS23
A	THR24
A	THR25
A	ASN145
A	LYS146
A	GLU148
A	LEU149
A	SER180
A	ALA181
A	LEU182
A	MG413
A	HOH1004
A	HOH1020
A	HOH1024
A	HOH1029
A	HOH1032
A	HOH1038
A	HOH1194
A	HOH1204
A	HOH1215

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q980A5, ECO:0000255|HAMAP-Rule:MF_00119

Chain	Residue	Details
A	ASP20
A	GLY45
A	THR47

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:11927566, ECO:0007744|PDB:1KK1, ECO:0007744|PDB:1KK2, ECO:0007744|PDB:1KK3

Chain	Residue	Details
A	THR24
A	ASN145
A	SER180

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00119, ECO:0000269|PubMed:11927566, ECO:0007744|PDB:1KJZ, ECO:0007744|PDB:1KK0, ECO:0007744|PDB:1KK1, ECO:0007744|PDB:1KK2, ECO:0007744|PDB:1KK3

Chain	Residue	Details
A	CYS60
A	CYS63
A	CYS72
A	CYS75

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ASP20

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	HIS93

---