1KIC
Inosine-adenosine-guanosine preferring nucleoside hydrolase from Trypanosoma vivax: Asp10Ala mutant in complex with inosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0008477 | molecular_function | purine nucleosidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0008477 | molecular_function | purine nucleosidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 328 |
| Chain | Residue |
| A | ASP15 |
| A | THR137 |
| A | ASP261 |
| A | NOS801 |
| A | HOH805 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 328 |
| Chain | Residue |
| B | HOH803 |
| B | ASP15 |
| B | THR137 |
| B | ASP261 |
| B | NOS802 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI A 701 |
| Chain | Residue |
| A | GLU44 |
| A | GLU113 |
| A | NOS804 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NOS A 801 |
| Chain | Residue |
| A | ASN12 |
| A | ASP14 |
| A | ASP15 |
| A | ASP40 |
| A | LYS81 |
| A | THR137 |
| A | ASN173 |
| A | GLU184 |
| A | ASN186 |
| A | TYR257 |
| A | TRP260 |
| A | ASP261 |
| A | CA328 |
| A | HOH1101 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NOS B 802 |
| Chain | Residue |
| B | ASN12 |
| B | ASP14 |
| B | ASP15 |
| B | ASP40 |
| B | TRP83 |
| B | THR137 |
| B | MET164 |
| B | ASN173 |
| B | GLU184 |
| B | ASN186 |
| B | TRP260 |
| B | ASP261 |
| B | CA328 |
| B | HOH902 |
| B | HOH1070 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NOS A 803 |
| Chain | Residue |
| A | ARG171 |
| A | PHE175 |
| A | LEU176 |
| A | PRO177 |
| A | THR179 |
| A | ASP180 |
| A | GLY181 |
| A | HOH990 |
| B | GLU314 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NOS A 804 |
| Chain | Residue |
| A | GLU44 |
| A | LYS109 |
| A | GLU113 |
| A | ASP298 |
| A | NI701 |
| A | HOH883 |
| A | HOH1036 |
| A | HOH1102 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 471 |
| Chain | Residue | Details |
| A | ALA10 | metal ligand, proton shuttle (general acid/base) |
| A | ASP15 | metal ligand |
| A | ASP40 | activator |
| A | TRP83 | activator |
| A | THR137 | metal ligand |
| A | ASN186 | activator, electrostatic stabiliser |
| A | TRP260 | activator, electrostatic stabiliser |
| A | ASP261 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 471 |
| Chain | Residue | Details |
| B | ALA10 | metal ligand, proton shuttle (general acid/base) |
| B | ASP15 | metal ligand |
| B | ASP40 | activator |
| B | TRP83 | activator |
| B | THR137 | metal ligand |
| B | ASN186 | activator, electrostatic stabiliser |
| B | TRP260 | activator, electrostatic stabiliser |
| B | ASP261 | metal ligand |
