1KHR

Crystal Structure of Vat(D) in Complex with Virginiamycin and Coenzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0046677	biological_process	response to antibiotic
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0046677	biological_process	response to antibiotic
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0046677	biological_process	response to antibiotic
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0046677	biological_process	response to antibiotic
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0046677	biological_process	response to antibiotic
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE VIR A 401

Chain	Residue
A	VAL17
B	PRO103
A	TYR37
A	ASP39
A	COA301
A	HOH3603
B	ILE56
B	ASN81
B	ASN92
B	LEU93

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE VIR A 402

Chain	Residue
A	TYR54
A	ALA80
A	ASN81
A	HIS82
A	ASN92
A	LEU93
A	PRO103
C	TYR37
C	ASP39
C	COA303

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE VIR E 403

Chain	Residue
D	TYR37
D	ASP39
D	COA304
E	TYR54
E	GLY79
E	ASN81
E	ASN92
E	PRO103
E	HOH3622

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA A 301

Chain	Residue
A	TRP121
A	LYS124
A	ALA141
A	ALA142
A	LEU155
A	GLY157
A	GLY158
A	ILE164
A	VIR401
A	HOH3608
B	ALA80
B	MET84
B	MET129
B	VAL147

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA B 302

Chain	Residue
B	TRP121
B	GLY123
B	LYS124
B	ALA141
B	ALA142
B	LEU155
B	GLY157
B	GLY158
B	ILE164
B	HOH3577
B	HOH3612
C	HIS82
C	MET84
C	MET129
C	VAL147
C	LYS148
C	PRO160

---

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE COA C 303

Chain	Residue
A	HIS82
A	MET84
A	MET129
A	VAL147
A	PRO160
A	VIR402
A	HOH3607
C	TRP121
C	GLY123
C	LYS124
C	ALA141
C	ALA142
C	LEU155
C	GLY157
C	GLY158
C	ILE164
C	HOH3605
C	HOH3606

---

site_id	AC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE COA D 304

Chain	Residue
D	GLY70
D	TRP121
D	ILE122
D	GLY123
D	LYS124
D	ALA141
D	ALA142
D	LEU155
D	GLY157
D	GLY158
D	ILE164
D	HOH3614
E	HIS82
E	MET84
E	MET129
E	VAL147
E	PRO160
E	VIR403

---

site_id	AC8
Number of Residues	17
Details	BINDING SITE FOR RESIDUE COA E 305

Chain	Residue
E	ALA141
E	ALA142
E	LEU155
E	GLY157
E	GLY158
E	ILE164
E	HOH3557
E	HOH3558
E	HOH3615
F	ALA80
F	MET84
F	VAL147
F	LYS148
F	PRO160
E	TRP121
E	GLY123
E	LYS124

---

site_id	AC9
Number of Residues	15
Details	BINDING SITE FOR RESIDUE COA F 306

Chain	Residue
D	HIS82
D	MET84
D	MET129
D	VAL147
D	PRO160
F	TRP121
F	GLY123
F	LYS124
F	ALA141
F	ALA142
F	LEU155
F	GLY157
F	GLY158
F	ILE164
F	HOH3621

---

Functional Information from PROSITE/UniProt

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGkdVvImpgVkIGdgAiVAanSvVvkdI

Chain	Residue	Details
A	ILE122-ILE150

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
A	PHE94

---

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
D	PHE91

---

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
E	PHE91

---

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
F	PHE91

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
B	PHE94

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
C	PHE94

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
D	PHE94

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
E	PHE94

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
F	PHE94

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
A	PHE91

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
B	PHE91

---

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1lxa

Chain	Residue	Details
C	PHE91

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