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1KF9

PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0002092biological_processpositive regulation of receptor internalization
A0005125molecular_functioncytokine activity
A0005131molecular_functiongrowth hormone receptor binding
A0005148molecular_functionprolactin receptor binding
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0010828biological_processpositive regulation of glucose transmembrane transport
A0019221biological_processcytokine-mediated signaling pathway
A0031667biological_processresponse to nutrient levels
A0031904cellular_componentendosome lumen
A0032355biological_processresponse to estradiol
A0040018biological_processpositive regulation of multicellular organism growth
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0043406biological_processpositive regulation of MAP kinase activity
A0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
A0045927biological_processpositive regulation of growth
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046872molecular_functionmetal ion binding
A0048513biological_processanimal organ development
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060396biological_processgrowth hormone receptor signaling pathway
A0060397biological_processgrowth hormone receptor signaling pathway via JAK-STAT
A0062023cellular_componentcollagen-containing extracellular matrix
A0070186molecular_functiongrowth hormone activity
A0070195cellular_componentgrowth hormone receptor complex
A0070977biological_processbone maturation
A0097696biological_processcell surface receptor signaling pathway via STAT
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
D0002092biological_processpositive regulation of receptor internalization
D0005125molecular_functioncytokine activity
D0005131molecular_functiongrowth hormone receptor binding
D0005148molecular_functionprolactin receptor binding
D0005179molecular_functionhormone activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008083molecular_functiongrowth factor activity
D0010828biological_processpositive regulation of glucose transmembrane transport
D0019221biological_processcytokine-mediated signaling pathway
D0031667biological_processresponse to nutrient levels
D0031904cellular_componentendosome lumen
D0032355biological_processresponse to estradiol
D0040018biological_processpositive regulation of multicellular organism growth
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0043406biological_processpositive regulation of MAP kinase activity
D0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
D0045927biological_processpositive regulation of growth
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048513biological_processanimal organ development
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060396biological_processgrowth hormone receptor signaling pathway
D0060397biological_processgrowth hormone receptor signaling pathway via JAK-STAT
D0062023cellular_componentcollagen-containing extracellular matrix
D0070186molecular_functiongrowth hormone activity
D0070195cellular_componentgrowth hormone receptor complex
D0070977biological_processbone maturation
D0097696biological_processcell surface receptor signaling pathway via STAT
E0004896molecular_functioncytokine receptor activity
E0016020cellular_componentmembrane
F0004896molecular_functioncytokine receptor activity
F0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00266
Number of Residues34
DetailsSOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. CpSesIpTPsnkeeTqqksnleLlrisllLiqSW
ChainResidueDetails
ACYS53-TRP86

site_idPS00338
Number of Residues18
DetailsSOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CFNkDMsKVStYlrTvqC
ChainResidueDetails
ACYS165-CYS182

site_idPS01352
Number of Residues79
DetailsHEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. IqVrWeaprnadiqkgwmvleYELqykevnetkwkmmdpilttsvpvys..LkvdkeyevrvRsKqrnsgn...YgeFsevlyV
ChainResidueDetails
BILE353-VAL431

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP18
CASN682
EASN1228
EASN1297
EASN1338
EASN1343
EASN1382
FASN1528
FASN1597
FASN1638
FASN1643
ASER174
FASN1682
DASP1018
DSER1174
BASN382
CASN528
CASN597
CASN638
CASN643

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:14997482
ChainResidueDetails
ASER106
ASER150
DSER1106
DSER1150

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Deamidated glutamine; by deterioration => ECO:0000269|PubMed:7028740
ChainResidueDetails
AGLN137
DGLN1137

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Deamidated asparagine; by deterioration => ECO:0000269|PubMed:7028740
ChainResidueDetails
AASN152
DASN1152

223166

PDB entries from 2024-07-31

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