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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

1KF9

PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR

Functional Information from GO Data
ChainGOidnamespacecontents
A0002092biological_processpositive regulation of receptor internalization
A0005125molecular_functioncytokine activity
A0005131molecular_functiongrowth hormone receptor binding
A0005148molecular_functionprolactin receptor binding
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008083molecular_functiongrowth factor activity
A0010828biological_processpositive regulation of D-glucose transmembrane transport
A0012505cellular_componentendomembrane system
A0019221biological_processcytokine-mediated signaling pathway
A0031012cellular_componentextracellular matrix
A0031667biological_processresponse to nutrient levels
A0031904cellular_componentendosome lumen
A0031982cellular_componentvesicle
A0032355biological_processresponse to estradiol
A0040018biological_processpositive regulation of multicellular organism growth
A0043410biological_processpositive regulation of MAPK cascade
A0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046872molecular_functionmetal ion binding
A0048513biological_processanimal organ development
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060396biological_processgrowth hormone receptor signaling pathway
A0060397biological_processgrowth hormone receptor signaling pathway via JAK-STAT
A0070186molecular_functiongrowth hormone activity
A0070195cellular_componentgrowth hormone receptor complex
A0070977biological_processbone maturation
A0097696biological_processcell surface receptor signaling pathway via STAT
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
D0002092biological_processpositive regulation of receptor internalization
D0005125molecular_functioncytokine activity
D0005131molecular_functiongrowth hormone receptor binding
D0005148molecular_functionprolactin receptor binding
D0005179molecular_functionhormone activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008083molecular_functiongrowth factor activity
D0010828biological_processpositive regulation of D-glucose transmembrane transport
D0012505cellular_componentendomembrane system
D0019221biological_processcytokine-mediated signaling pathway
D0031012cellular_componentextracellular matrix
D0031667biological_processresponse to nutrient levels
D0031904cellular_componentendosome lumen
D0031982cellular_componentvesicle
D0032355biological_processresponse to estradiol
D0040018biological_processpositive regulation of multicellular organism growth
D0043410biological_processpositive regulation of MAPK cascade
D0043568biological_processpositive regulation of insulin-like growth factor receptor signaling pathway
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046872molecular_functionmetal ion binding
D0048513biological_processanimal organ development
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0060396biological_processgrowth hormone receptor signaling pathway
D0060397biological_processgrowth hormone receptor signaling pathway via JAK-STAT
D0070186molecular_functiongrowth hormone activity
D0070195cellular_componentgrowth hormone receptor complex
D0070977biological_processbone maturation
D0097696biological_processcell surface receptor signaling pathway via STAT
E0004896molecular_functioncytokine receptor activity
E0016020cellular_componentmembrane
F0004896molecular_functioncytokine receptor activity
F0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00266
Number of Residues34
DetailsSOMATOTROPIN_1 Somatotropin, prolactin and related hormones signature 1. CpSesIpTPsnkeeTqqksnleLlrisllLiqSW
ChainResidueDetails
ACYS53-TRP86
site_idPS00338
Number of Residues18
DetailsSOMATOTROPIN_2 Somatotropin, prolactin and related hormones signature 2. CFNkDMsKVStYlrTvqC
ChainResidueDetails
ACYS165-CYS182
site_idPS01352
Number of Residues79
DetailsHEMATOPO_REC_L_F1 Long hematopoietin receptor, single chain family signature. IqVrWeaprnadiqkgwmvleYELqykevnetkwkmmdpilttsvpvys..LkvdkeyevrvRsKqrnsgn...YgeFsevlyV
ChainResidueDetails
BILE353-VAL431
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"14997482","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues103
DetailsDomain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsMotif: {"description":"WSXWS motif","evidences":[{"source":"PubMed","id":"14678285","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues16
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2025-11-19

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