1KEE
Inactivation of the Amidotransferase Activity of Carbamoyl Phosphate Synthetase by the Antibiotic Acivicin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006526 | biological_process | arginine biosynthetic process |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0016597 | molecular_function | amino acid binding |
A | 0016874 | molecular_function | ligase activity |
A | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
B | 0004359 | molecular_function | glutaminase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006526 | biological_process | arginine biosynthetic process |
B | 0006541 | biological_process | glutamine metabolic process |
B | 0016874 | molecular_function | ligase activity |
B | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0046982 | molecular_function | protein heterodimerization activity |
C | 0000166 | molecular_function | nucleotide binding |
C | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
C | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006526 | biological_process | arginine biosynthetic process |
C | 0006541 | biological_process | glutamine metabolic process |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0016597 | molecular_function | amino acid binding |
C | 0016874 | molecular_function | ligase activity |
C | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0046872 | molecular_function | metal ion binding |
D | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
D | 0004359 | molecular_function | glutaminase activity |
D | 0005515 | molecular_function | protein binding |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0006526 | biological_process | arginine biosynthetic process |
D | 0006541 | biological_process | glutamine metabolic process |
D | 0016874 | molecular_function | ligase activity |
D | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
D | 0046982 | molecular_function | protein heterodimerization activity |
E | 0000166 | molecular_function | nucleotide binding |
E | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
E | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
E | 0006526 | biological_process | arginine biosynthetic process |
E | 0006541 | biological_process | glutamine metabolic process |
E | 0008652 | biological_process | amino acid biosynthetic process |
E | 0016597 | molecular_function | amino acid binding |
E | 0016874 | molecular_function | ligase activity |
E | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
E | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
E | 0046872 | molecular_function | metal ion binding |
F | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
F | 0004359 | molecular_function | glutaminase activity |
F | 0005515 | molecular_function | protein binding |
F | 0005524 | molecular_function | ATP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
F | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
F | 0006526 | biological_process | arginine biosynthetic process |
F | 0006541 | biological_process | glutamine metabolic process |
F | 0016874 | molecular_function | ligase activity |
F | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
F | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
F | 0046982 | molecular_function | protein heterodimerization activity |
G | 0000166 | molecular_function | nucleotide binding |
G | 0004087 | molecular_function | carbamoyl-phosphate synthase (ammonia) activity |
G | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
G | 0005515 | molecular_function | protein binding |
G | 0005524 | molecular_function | ATP binding |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
G | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
G | 0006526 | biological_process | arginine biosynthetic process |
G | 0006541 | biological_process | glutamine metabolic process |
G | 0008652 | biological_process | amino acid biosynthetic process |
G | 0016597 | molecular_function | amino acid binding |
G | 0016874 | molecular_function | ligase activity |
G | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
G | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
G | 0046872 | molecular_function | metal ion binding |
H | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
H | 0004359 | molecular_function | glutaminase activity |
H | 0005515 | molecular_function | protein binding |
H | 0005524 | molecular_function | ATP binding |
H | 0005737 | cellular_component | cytoplasm |
H | 0005829 | cellular_component | cytosol |
H | 0005951 | cellular_component | carbamoyl-phosphate synthase complex |
H | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
H | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
H | 0006526 | biological_process | arginine biosynthetic process |
H | 0006541 | biological_process | glutamine metabolic process |
H | 0016874 | molecular_function | ligase activity |
H | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
H | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
H | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 2002 |
Chain | Residue |
A | GLU299 |
A | ASN301 |
A | ADP2001 |
A | PO42006 |
A | HOH5129 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 2003 |
Chain | Residue |
A | HOH5185 |
A | GLN285 |
A | GLU299 |
A | ADP2001 |
A | PO42006 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 5004 |
Chain | Residue |
A | GLU215 |
A | ASN236 |
A | ASP238 |
A | ALA239 |
A | ILE242 |
A | SER247 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K A 5005 |
Chain | Residue |
A | ALA126 |
A | GLU127 |
A | GLU299 |
A | MET300 |
A | ASN301 |
A | HOH5128 |
A | HOH5129 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 5008 |
Chain | Residue |
A | GLN829 |
A | GLU841 |
A | ADP2007 |
A | HOH5501 |
A | HOH5502 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K A 5009 |
Chain | Residue |
A | GLU841 |
A | ASN843 |
A | ADP2007 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 5010 |
Chain | Residue |
A | GLU761 |
A | HIS781 |
A | GLU783 |
A | GLN784 |
A | VAL787 |
A | SER792 |
site_id | AC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K A 5013 |
Chain | Residue |
A | THR143 |
A | ALA144 |
A | HOH5134 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 5014 |
Chain | Residue |
A | GLY382 |
A | GLU383 |
A | ASN570 |
A | ASN602 |
A | GLU604 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K A 5015 |
Chain | Residue |
A | ASP84 |
A | GLY112 |
A | THR114 |
A | HOH5026 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K B 5016 |
Chain | Residue |
A | HOH5421 |
B | HIS16 |
B | ASP112 |
B | HOH5068 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL A 5017 |
Chain | Residue |
A | GLN93 |
A | THR173 |
A | MET174 |
A | HOH5047 |
A | HOH5095 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 5018 |
Chain | Residue |
A | ASN289 |
A | ASN292 |
A | ARG294 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 5019 |
Chain | Residue |
A | ASN371 |
A | PHE900 |
A | PRO901 |
A | GLY902 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A 5020 |
Chain | Residue |
A | LYS475 |
A | ASN485 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL B 5021 |
Chain | Residue |
A | GLU549 |
B | PHE15 |
B | ASP114 |
B | HOH5069 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN C 2024 |
Chain | Residue |
C | GLU299 |
C | ASN301 |
C | ADP2023 |
C | PO42028 |
C | HOH5151 |
site_id | BC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN C 2025 |
Chain | Residue |
C | GLN285 |
C | GLU299 |
C | ADP2023 |
C | PO42028 |
C | HOH5205 |
site_id | CC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K C 5026 |
Chain | Residue |
C | GLU215 |
C | ASN236 |
C | ASP238 |
C | ALA239 |
C | ILE242 |
C | SER247 |
site_id | CC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K C 5027 |
Chain | Residue |
C | ALA126 |
C | GLU127 |
C | GLU299 |
C | MET300 |
C | ASN301 |
C | HOH5150 |
C | HOH5618 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN C 2030 |
Chain | Residue |
C | GLN829 |
C | GLU841 |
C | ADP2029 |
C | HOH5518 |
C | HOH5519 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K C 5031 |
Chain | Residue |
C | GLU841 |
C | ASN843 |
C | ADP2029 |
site_id | CC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K C 5032 |
Chain | Residue |
C | GLU761 |
C | HIS781 |
C | GLU783 |
C | GLN784 |
C | VAL787 |
C | SER792 |
site_id | CC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K C 5035 |
Chain | Residue |
C | THR143 |
C | ALA144 |
C | HOH5156 |
site_id | CC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K C 5036 |
Chain | Residue |
C | GLY382 |
C | GLU383 |
C | ASN570 |
C | ASN602 |
C | GLU604 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K C 5037 |
Chain | Residue |
C | ASP84 |
C | GLY112 |
C | THR114 |
C | HOH5047 |
site_id | CC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE K D 5038 |
Chain | Residue |
C | HOH5439 |
D | HIS16 |
D | ASP112 |
site_id | DC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 5039 |
Chain | Residue |
C | THR173 |
C | MET174 |
site_id | DC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL C 5040 |
Chain | Residue |
C | ASN289 |
C | ASN292 |
C | ARG294 |
site_id | DC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL C 5041 |
Chain | Residue |
C | ALA370 |
C | ASN371 |
C | PHE900 |
C | PRO901 |
C | GLY902 |
site_id | DC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 5042 |
Chain | Residue |
C | LYS475 |
C | ASN485 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL D 5043 |
Chain | Residue |
C | GLU549 |
C | HOH5439 |
D | ASP114 |
D | HOH1763 |
site_id | DC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL C 5044 |
Chain | Residue |
C | PHE578 |
C | ARG845 |
C | ALA847 |
C | ARG848 |
site_id | DC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN E 2046 |
Chain | Residue |
E | GLU299 |
E | ASN301 |
E | ADP2045 |
E | MN2047 |
E | PO42050 |
E | HOH5178 |
site_id | DC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN E 2047 |
Chain | Residue |
E | GLN285 |
E | GLU299 |
E | ADP2045 |
E | MN2046 |
E | PO42050 |
E | HOH5232 |
site_id | DC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K E 2048 |
Chain | Residue |
E | GLU215 |
E | ASN236 |
E | ASP238 |
E | ALA239 |
E | ILE242 |
E | SER247 |
site_id | EC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K E 5049 |
Chain | Residue |
E | ALA126 |
E | GLU127 |
E | GLU299 |
E | MET300 |
E | ASN301 |
E | HOH5177 |
E | HOH5178 |
site_id | EC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN E 2052 |
Chain | Residue |
E | GLN829 |
E | GLU841 |
E | ADP2051 |
E | HOH5543 |
E | HOH5544 |
site_id | EC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K E 5053 |
Chain | Residue |
E | GLU841 |
E | ASN843 |
E | ADP2051 |
E | HOH5547 |
E | HOH5816 |
site_id | EC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K E 5054 |
Chain | Residue |
E | GLU761 |
E | HIS781 |
E | GLU783 |
E | GLN784 |
E | VAL787 |
E | SER792 |
site_id | EC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K E 5057 |
Chain | Residue |
E | THR143 |
E | ALA144 |
E | HOH5183 |
E | HOH5188 |
site_id | EC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K E 5058 |
Chain | Residue |
E | GLY382 |
E | GLU383 |
E | ASN570 |
E | ASN602 |
E | GLU604 |
site_id | EC7 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K E 5059 |
Chain | Residue |
E | ASP84 |
E | GLY112 |
E | THR114 |
E | HOH5073 |
E | HOH5074 |
site_id | EC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K F 5060 |
Chain | Residue |
E | HOH5465 |
F | HIS16 |
F | ASP112 |
F | HOH2843 |
site_id | EC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL E 5061 |
Chain | Residue |
E | GLN93 |
E | THR173 |
E | MET174 |
E | HOH5141 |
site_id | FC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL E 5062 |
Chain | Residue |
E | ASN289 |
E | ASN292 |
E | ARG294 |
site_id | FC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CL E 5063 |
Chain | Residue |
E | ALA370 |
E | ASN371 |
E | PHE900 |
E | PRO901 |
E | GLY902 |
site_id | FC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL E 5064 |
Chain | Residue |
E | LYS475 |
E | ASN485 |
E | HOH5420 |
site_id | FC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL F 5065 |
Chain | Residue |
F | ASP114 |
F | HOH2844 |
site_id | FC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MN G 2067 |
Chain | Residue |
G | MET174 |
G | GLU299 |
G | ASN301 |
G | ADP2066 |
G | MN2068 |
G | PO42071 |
G | HOH3501 |
site_id | FC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN G 2068 |
Chain | Residue |
G | GLN285 |
G | GLU299 |
G | ADP2066 |
G | MN2067 |
G | PO42071 |
G | HOH3558 |
site_id | FC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K G 2069 |
Chain | Residue |
G | GLU215 |
G | ASN236 |
G | ASP238 |
G | ALA239 |
G | ILE242 |
G | SER247 |
site_id | FC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE K G 5070 |
Chain | Residue |
G | ALA126 |
G | GLU127 |
G | GLU299 |
G | MET300 |
G | ASN301 |
G | HOH3500 |
G | HOH3501 |
site_id | FC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN G 2073 |
Chain | Residue |
G | GLN829 |
G | GLU841 |
G | ADP2072 |
G | HOH3912 |
G | HOH3913 |
site_id | GC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K G 5074 |
Chain | Residue |
G | GLU841 |
G | ASN843 |
G | ADP2072 |
G | HOH3879 |
G | HOH3916 |
site_id | GC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K G 5075 |
Chain | Residue |
G | GLU761 |
G | HIS781 |
G | GLU783 |
G | GLN784 |
G | VAL787 |
G | SER792 |
site_id | GC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K G 5078 |
Chain | Residue |
G | THR143 |
G | ALA144 |
G | HOH3506 |
G | HOH3511 |
site_id | GC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K G 5079 |
Chain | Residue |
G | GLY382 |
G | GLU383 |
G | ASN570 |
G | ASN602 |
G | GLU604 |
site_id | GC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K G 5080 |
Chain | Residue |
G | ASP84 |
G | GLY112 |
G | THR114 |
G | HOH3396 |
site_id | GC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE K H 5081 |
Chain | Residue |
H | HIS16 |
H | ASP112 |
site_id | GC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL G 5082 |
Chain | Residue |
G | GLN93 |
G | THR173 |
G | MET174 |
G | HOH3464 |
site_id | GC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL G 5083 |
Chain | Residue |
G | ASN289 |
G | ASN292 |
G | ARG294 |
site_id | GC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL G 5084 |
Chain | Residue |
G | ALA370 |
G | ASN371 |
G | PHE900 |
G | PRO901 |
G | GLY902 |
G | HOH3713 |
site_id | HC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL G 5085 |
Chain | Residue |
G | LYS475 |
G | ASN485 |
site_id | HC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL H 5086 |
Chain | Residue |
H | PHE15 |
H | ASP114 |
site_id | HC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE PO4 A 2006 |
Chain | Residue |
A | MET174 |
A | GLY175 |
A | HIS243 |
A | GLN285 |
A | GLU299 |
A | ASN301 |
A | ARG303 |
A | ARG306 |
A | ADP2001 |
A | MN2002 |
A | MN2003 |
A | HOH5185 |
A | HOH5240 |
A | HOH5577 |
site_id | HC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE PO4 C 2028 |
Chain | Residue |
C | MET174 |
C | GLY175 |
C | HIS243 |
C | GLN285 |
C | GLU299 |
C | ASN301 |
C | ARG303 |
C | ARG306 |
C | ADP2023 |
C | MN2024 |
C | MN2025 |
C | HOH5259 |
C | HOH5592 |
site_id | HC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE PO4 E 2050 |
Chain | Residue |
E | MET174 |
E | GLY175 |
E | HIS243 |
E | GLN285 |
E | GLU299 |
E | ASN301 |
E | ARG303 |
E | ARG306 |
E | ADP2045 |
E | MN2046 |
E | MN2047 |
E | HOH5103 |
E | HOH5621 |
site_id | HC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE PO4 G 2071 |
Chain | Residue |
G | MET174 |
G | GLY175 |
G | HIS243 |
G | GLN285 |
G | GLU299 |
G | ASN301 |
G | ARG303 |
G | ARG306 |
G | ADP2066 |
G | MN2067 |
G | MN2068 |
G | HOH3426 |
G | HOH4112 |
site_id | HC7 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE ADP A 2001 |
Chain | Residue |
A | ARG129 |
A | ILE167 |
A | ARG169 |
A | THR173 |
A | MET174 |
A | GLY175 |
A | GLY176 |
A | GLU208 |
A | LEU210 |
A | ILE211 |
A | GLU215 |
A | MET240 |
A | GLY241 |
A | ILE242 |
A | HIS243 |
A | THR244 |
A | GLN285 |
A | ILE298 |
A | GLU299 |
A | THR376 |
A | MN2002 |
A | MN2003 |
A | PO42006 |
A | HOH5129 |
A | HOH5170 |
A | HOH5185 |
A | HOH5631 |
site_id | HC8 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE ADP A 2007 |
Chain | Residue |
A | PRO690 |
A | ARG715 |
A | MET725 |
A | HIS754 |
A | PHE755 |
A | LEU756 |
A | GLU761 |
A | ALA785 |
A | GLY786 |
A | VAL787 |
A | HIS788 |
A | SER789 |
A | GLN829 |
A | GLU841 |
A | MN5008 |
A | K5009 |
A | HOH5441 |
A | HOH5470 |
A | HOH5501 |
A | HOH5502 |
A | HOH5504 |
A | HOH5768 |
A | HOH5840 |
A | HOH5849 |
site_id | HC9 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORN A 5011 |
Chain | Residue |
A | GLU783 |
A | ASP791 |
A | GLU892 |
A | LEU907 |
A | TYR1040 |
A | ASP1041 |
A | THR1042 |
A | HOH5482 |
A | HOH5525 |
A | HOH5781 |
site_id | IC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NET A 5012 |
Chain | Residue |
A | GLN22 |
A | THR94 |
A | HOH5045 |
site_id | IC2 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE ADP C 2023 |
Chain | Residue |
C | ARG129 |
C | ILE167 |
C | ARG169 |
C | THR173 |
C | MET174 |
C | GLY175 |
C | GLY176 |
C | GLU208 |
C | LEU210 |
C | ILE211 |
C | GLU215 |
C | MET240 |
C | GLY241 |
C | ILE242 |
C | HIS243 |
C | THR244 |
C | GLN285 |
C | ILE298 |
C | GLU299 |
C | THR376 |
C | MN2024 |
C | MN2025 |
C | PO42028 |
C | HOH5151 |
C | HOH5190 |
C | HOH5205 |
C | HOH5610 |
site_id | IC3 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE ADP C 2029 |
Chain | Residue |
C | PRO690 |
C | ARG715 |
C | MET725 |
C | HIS754 |
C | PHE755 |
C | LEU756 |
C | GLU761 |
C | ALA785 |
C | GLY786 |
C | VAL787 |
C | HIS788 |
C | SER789 |
C | GLN829 |
C | GLU841 |
C | MN2030 |
C | K5031 |
C | HOH5459 |
C | HOH5487 |
C | HOH5518 |
C | HOH5519 |
C | HOH5522 |
C | HOH5801 |
site_id | IC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORN C 5033 |
Chain | Residue |
C | GLU783 |
C | ASP791 |
C | ALA793 |
C | GLU892 |
C | LEU907 |
C | TYR1040 |
C | ASP1041 |
C | THR1042 |
C | HOH5499 |
C | HOH5543 |
site_id | IC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NET C 5034 |
Chain | Residue |
C | GLN22 |
C | THR94 |
C | ASN97 |
C | ASN936 |
C | HOH5069 |
site_id | IC6 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE ADP E 2045 |
Chain | Residue |
E | ARG129 |
E | ILE167 |
E | ARG169 |
E | THR173 |
E | MET174 |
E | GLY175 |
E | GLY176 |
E | GLU208 |
E | LEU210 |
E | ILE211 |
E | GLU215 |
E | MET240 |
E | GLY241 |
E | ILE242 |
E | HIS243 |
E | THR244 |
E | GLN285 |
E | ILE298 |
E | GLU299 |
E | THR376 |
E | MN2046 |
E | MN2047 |
E | PO42050 |
E | HOH5178 |
E | HOH5219 |
E | HOH5232 |
site_id | IC7 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE ADP E 2051 |
Chain | Residue |
E | PRO690 |
E | VAL713 |
E | ARG715 |
E | MET725 |
E | HIS754 |
E | PHE755 |
E | LEU756 |
E | GLU761 |
E | ALA785 |
E | GLY786 |
E | VAL787 |
E | HIS788 |
E | SER789 |
E | GLN829 |
E | GLU841 |
E | MN2052 |
E | K5053 |
E | HOH5484 |
E | HOH5512 |
E | HOH5544 |
E | HOH5547 |
E | HOH5816 |
site_id | IC8 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE ORN E 5055 |
Chain | Residue |
E | GLU783 |
E | ASP791 |
E | GLU892 |
E | LEU907 |
E | TYR1040 |
E | ASP1041 |
E | THR1042 |
E | HOH5524 |
E | HOH5568 |
E | HOH5570 |
E | HOH5872 |
site_id | IC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NET E 5056 |
Chain | Residue |
E | GLN93 |
E | THR94 |
E | HOH5095 |
site_id | JC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE ADP G 2066 |
Chain | Residue |
G | ARG129 |
G | ILE167 |
G | ARG169 |
G | THR173 |
G | MET174 |
G | GLY175 |
G | GLY176 |
G | GLU208 |
G | LEU210 |
G | ILE211 |
G | GLU215 |
G | MET240 |
G | GLY241 |
G | ILE242 |
G | HIS243 |
G | THR244 |
G | GLN285 |
G | GLU299 |
G | THR376 |
G | MN2067 |
G | MN2068 |
G | PO42071 |
G | HOH3543 |
G | HOH3558 |
site_id | JC2 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE ADP G 2072 |
Chain | Residue |
G | ARG715 |
G | MET725 |
G | HIS754 |
G | PHE755 |
G | LEU756 |
G | GLU761 |
G | ALA785 |
G | GLY786 |
G | VAL787 |
G | HIS788 |
G | SER789 |
G | GLN829 |
G | GLU841 |
G | MN2073 |
G | HOH3852 |
G | HOH3879 |
G | HOH3912 |
G | HOH3913 |
G | HOH3916 |
G | K5074 |
site_id | JC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE ORN G 5076 |
Chain | Residue |
G | GLU783 |
G | ASP791 |
G | GLU892 |
G | LEU895 |
G | LEU907 |
G | TYR1040 |
G | ASP1041 |
G | THR1042 |
G | HOH3893 |
G | HOH3937 |
site_id | JC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NET G 5077 |
Chain | Residue |
G | GLN22 |
G | THR94 |
G | ASN97 |
G | HOH3416 |
Functional Information from PROSITE/UniProt
site_id | PS00866 |
Number of Residues | 15 |
Details | CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG |
Chain | Residue | Details |
A | PHE164-GLY178 | |
A | TYR710-ALA724 |
site_id | PS00867 |
Number of Residues | 8 |
Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV |
Chain | Residue | Details |
A | VAL297-VAL304 | |
A | LEU839-ALA846 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209 |
Chain | Residue | Details |
B | 143269 | |
A | THR244 | |
A | PRO716 | |
A | PHE755 | |
A | ASP757 | |
A | VAL762 | |
A | VAL787 | |
A | HIS788 | |
A | SER789 | |
A | GLY790 | |
C | ARG130 | |
D | 143269 | |
C | PRO170 | |
C | GLY176 | |
C | SER177 | |
C | SER209 | |
C | ILE211 | |
C | TYR216 | |
C | ILE242 | |
C | HIS243 | |
C | THR244 | |
C | PRO716 | |
F | 143269 | |
C | PHE755 | |
C | ASP757 | |
C | VAL762 | |
C | VAL787 | |
C | HIS788 | |
C | SER789 | |
C | GLY790 | |
E | ARG130 | |
E | PRO170 | |
E | GLY176 | |
H | 143269 | |
E | SER177 | |
E | SER209 | |
E | ILE211 | |
E | TYR216 | |
E | ILE242 | |
E | HIS243 | |
E | THR244 | |
E | PRO716 | |
E | PHE755 | |
E | ASP757 | |
A | SER209 | |
E | VAL762 | |
E | VAL787 | |
E | HIS788 | |
E | SER789 | |
E | GLY790 | |
G | ARG130 | |
G | PRO170 | |
G | GLY176 | |
G | SER177 | |
G | SER209 | |
A | ILE211 | |
G | ILE211 | |
G | TYR216 | |
G | ILE242 | |
G | HIS243 | |
G | THR244 | |
G | PRO716 | |
G | PHE755 | |
G | ASP757 | |
G | VAL762 | |
G | VAL787 | |
A | TYR216 | |
G | HIS788 | |
G | SER789 | |
G | GLY790 | |
A | ILE242 | |
A | HIS243 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01209 |
Chain | Residue | Details |
B | HIS353 | |
B | GLU355 | |
D | HIS353 | |
D | GLU355 | |
F | HIS353 | |
F | GLU355 | |
H | HIS353 | |
H | GLU355 |
site_id | SWS_FT_FI3 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01209, ECO:0000269|PubMed:10587438, ECO:0007744|PDB:1C3O |
Chain | Residue | Details |
B | SER47 | |
D | GLY241 | |
D | GLY243 | |
D | LEU270 | |
D | GLN273 | |
D | ASN311 | |
D | GLY313 | |
D | PHE314 | |
F | SER47 | |
F | GLY241 | |
F | GLY243 | |
B | GLY241 | |
F | LEU270 | |
F | GLN273 | |
F | ASN311 | |
F | GLY313 | |
F | PHE314 | |
H | SER47 | |
H | GLY241 | |
H | GLY243 | |
H | LEU270 | |
H | GLN273 | |
B | GLY243 | |
H | ASN311 | |
H | GLY313 | |
H | PHE314 | |
B | LEU270 | |
B | GLN273 | |
B | ASN311 | |
B | GLY313 | |
B | PHE314 | |
D | SER47 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 |
Chain | Residue | Details |
A | PHE830 | |
C | PHE830 | |
E | PHE830 | |
G | PHE830 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8 |
Chain | Residue | Details |
A | VAL842 | |
C | VAL842 | |
E | VAL842 | |
G | VAL842 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390 |
Chain | Residue | Details |
A | PRO844 | |
C | PRO844 | |
E | PRO844 | |
G | PRO844 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
B | HIS353 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
D | HIS353 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
F | HIS353 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
H | HIS353 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
B | HIS353 | |
B | 143269 | |
B | GLU355 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
D | HIS353 | |
D | 143269 | |
D | GLU355 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
F | HIS353 | |
F | 143269 | |
F | GLU355 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1bxr |
Chain | Residue | Details |
H | HIS353 | |
H | 143269 | |
H | GLU355 |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
B | 143269 | covalent catalysis, proton shuttle (general acid/base) |
A | VAL304 | electrostatic stabiliser |
A | PRO716 | electrostatic stabiliser |
A | GLY722 | electrostatic stabiliser |
A | ARG723 | electrostatic stabiliser |
A | VAL762 | steric role |
A | PHE830 | metal ligand |
A | VAL842 | metal ligand |
A | PRO844 | metal ligand |
A | THR849 | electrostatic stabiliser |
B | HIS353 | proton shuttle (general acid/base) |
B | GLU355 | steric role |
A | TYR216 | steric role |
A | THR244 | proton shuttle (general acid/base) |
A | VAL284 | electrostatic stabiliser |
A | PHE286 | metal ligand |
A | MET300 | metal ligand |
A | PRO302 | metal ligand |
site_id | MCSA2 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
D | 143269 | covalent catalysis, proton shuttle (general acid/base) |
C | VAL304 | electrostatic stabiliser |
C | PRO716 | electrostatic stabiliser |
C | GLY722 | electrostatic stabiliser |
C | ARG723 | electrostatic stabiliser |
C | VAL762 | steric role |
C | PHE830 | metal ligand |
C | VAL842 | metal ligand |
C | PRO844 | metal ligand |
C | THR849 | electrostatic stabiliser |
D | HIS353 | proton shuttle (general acid/base) |
D | GLU355 | steric role |
C | TYR216 | steric role |
C | THR244 | proton shuttle (general acid/base) |
C | VAL284 | electrostatic stabiliser |
C | PHE286 | metal ligand |
C | MET300 | metal ligand |
C | PRO302 | metal ligand |
site_id | MCSA3 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
F | 143269 | covalent catalysis, proton shuttle (general acid/base) |
E | VAL304 | electrostatic stabiliser |
E | PRO716 | electrostatic stabiliser |
E | GLY722 | electrostatic stabiliser |
E | ARG723 | electrostatic stabiliser |
E | VAL762 | steric role |
E | PHE830 | metal ligand |
E | VAL842 | metal ligand |
E | PRO844 | metal ligand |
E | THR849 | electrostatic stabiliser |
F | HIS353 | proton shuttle (general acid/base) |
F | GLU355 | steric role |
E | TYR216 | steric role |
E | THR244 | proton shuttle (general acid/base) |
E | VAL284 | electrostatic stabiliser |
E | PHE286 | metal ligand |
E | MET300 | metal ligand |
E | PRO302 | metal ligand |
site_id | MCSA4 |
Number of Residues | 3 |
Details | M-CSA 435 |
Chain | Residue | Details |
H | 143269 | covalent catalysis, proton shuttle (general acid/base) |
G | VAL304 | electrostatic stabiliser |
G | PRO716 | electrostatic stabiliser |
G | GLY722 | electrostatic stabiliser |
G | ARG723 | electrostatic stabiliser |
G | VAL762 | steric role |
G | PHE830 | metal ligand |
G | VAL842 | metal ligand |
G | PRO844 | metal ligand |
G | THR849 | electrostatic stabiliser |
H | HIS353 | proton shuttle (general acid/base) |
H | GLU355 | steric role |
G | TYR216 | steric role |
G | THR244 | proton shuttle (general acid/base) |
G | VAL284 | electrostatic stabiliser |
G | PHE286 | metal ligand |
G | MET300 | metal ligand |
G | PRO302 | metal ligand |