1KAO
CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAP2A WITH GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005764 | cellular_component | lysosome |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | intracellular protein localization |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016020 | cellular_component | membrane |
| A | 0019003 | molecular_function | GDP binding |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0030336 | biological_process | negative regulation of cell migration |
| A | 0030496 | cellular_component | midbody |
| A | 0030659 | cellular_component | cytoplasmic vesicle membrane |
| A | 0031258 | cellular_component | lamellipodium membrane |
| A | 0032486 | biological_process | Rap protein signal transduction |
| A | 0036019 | cellular_component | endolysosome |
| A | 0045184 | biological_process | establishment of protein localization |
| A | 0046328 | biological_process | regulation of JNK cascade |
| A | 0048814 | biological_process | regulation of dendrite morphogenesis |
| A | 0051963 | biological_process | regulation of synapse assembly |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0098588 | cellular_component | bounding membrane of organelle |
| A | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| A | 0099072 | biological_process | regulation of postsynaptic membrane neurotransmitter receptor levels |
| A | 1903698 | biological_process | positive regulation of microvillus assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 168 |
| Chain | Residue |
| A | SER17 |
| A | GDP170 |
| A | HOH171 |
| A | HOH172 |
| A | HOH173 |
| A | HOH174 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 169 |
| Chain | Residue |
| A | HOH240 |
| A | ASP38 |
| A | HOH227 |
| A | HOH239 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE GDP A 170 |
| Chain | Residue |
| A | GLY13 |
| A | VAL14 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | ILE29 |
| A | GLU30 |
| A | LYS31 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | LEU120 |
| A | SER146 |
| A | ALA147 |
| A | MG168 |
| A | HOH171 |
| A | HOH172 |
| A | HOH173 |
| A | HOH179 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxin TcdA, and by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"22267739","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | THR61 |
