Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1K9A

Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0006468	biological_process	protein phosphorylation
A	0008285	biological_process	negative regulation of cell population proliferation
A	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019903	molecular_function	protein phosphatase binding
A	0032715	biological_process	negative regulation of interleukin-6 production
A	0034236	molecular_function	protein kinase A catalytic subunit binding
A	0034332	biological_process	adherens junction organization
A	0035556	biological_process	intracellular signal transduction
A	0042802	molecular_function	identical protein binding
A	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
A	0045779	biological_process	negative regulation of bone resorption
A	0046872	molecular_function	metal ion binding
A	0048709	biological_process	oligodendrocyte differentiation
A	0050765	biological_process	negative regulation of phagocytosis
A	0050776	biological_process	regulation of immune response
A	0050860	biological_process	negative regulation of T cell receptor signaling pathway
A	0050868	biological_process	negative regulation of T cell activation
A	0051239	biological_process	regulation of multicellular organismal process
A	0060368	biological_process	regulation of Fc receptor mediated stimulatory signaling pathway
A	0070064	molecular_function	proline-rich region binding
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0071375	biological_process	cellular response to peptide hormone stimulus
A	1990782	molecular_function	protein tyrosine kinase binding
B	0000166	molecular_function	nucleotide binding
B	0002250	biological_process	adaptive immune response
B	0002376	biological_process	immune system process
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005911	cellular_component	cell-cell junction
B	0006468	biological_process	protein phosphorylation
B	0008285	biological_process	negative regulation of cell population proliferation
B	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019903	molecular_function	protein phosphatase binding
B	0032715	biological_process	negative regulation of interleukin-6 production
B	0034236	molecular_function	protein kinase A catalytic subunit binding
B	0034332	biological_process	adherens junction organization
B	0035556	biological_process	intracellular signal transduction
B	0042802	molecular_function	identical protein binding
B	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
B	0045779	biological_process	negative regulation of bone resorption
B	0046872	molecular_function	metal ion binding
B	0048709	biological_process	oligodendrocyte differentiation
B	0050765	biological_process	negative regulation of phagocytosis
B	0050776	biological_process	regulation of immune response
B	0050860	biological_process	negative regulation of T cell receptor signaling pathway
B	0050868	biological_process	negative regulation of T cell activation
B	0051239	biological_process	regulation of multicellular organismal process
B	0060368	biological_process	regulation of Fc receptor mediated stimulatory signaling pathway
B	0070064	molecular_function	proline-rich region binding
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
B	0071375	biological_process	cellular response to peptide hormone stimulus
B	1990782	molecular_function	protein tyrosine kinase binding
C	0000166	molecular_function	nucleotide binding
C	0002250	biological_process	adaptive immune response
C	0002376	biological_process	immune system process
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0005911	cellular_component	cell-cell junction
C	0006468	biological_process	protein phosphorylation
C	0008285	biological_process	negative regulation of cell population proliferation
C	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019903	molecular_function	protein phosphatase binding
C	0032715	biological_process	negative regulation of interleukin-6 production
C	0034236	molecular_function	protein kinase A catalytic subunit binding
C	0034332	biological_process	adherens junction organization
C	0035556	biological_process	intracellular signal transduction
C	0042802	molecular_function	identical protein binding
C	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
C	0045779	biological_process	negative regulation of bone resorption
C	0046872	molecular_function	metal ion binding
C	0048709	biological_process	oligodendrocyte differentiation
C	0050765	biological_process	negative regulation of phagocytosis
C	0050776	biological_process	regulation of immune response
C	0050860	biological_process	negative regulation of T cell receptor signaling pathway
C	0050868	biological_process	negative regulation of T cell activation
C	0051239	biological_process	regulation of multicellular organismal process
C	0060368	biological_process	regulation of Fc receptor mediated stimulatory signaling pathway
C	0070064	molecular_function	proline-rich region binding
C	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
C	0071375	biological_process	cellular response to peptide hormone stimulus
C	1990782	molecular_function	protein tyrosine kinase binding
D	0000166	molecular_function	nucleotide binding
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0005911	cellular_component	cell-cell junction
D	0006468	biological_process	protein phosphorylation
D	0008285	biological_process	negative regulation of cell population proliferation
D	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019903	molecular_function	protein phosphatase binding
D	0032715	biological_process	negative regulation of interleukin-6 production
D	0034236	molecular_function	protein kinase A catalytic subunit binding
D	0034332	biological_process	adherens junction organization
D	0035556	biological_process	intracellular signal transduction
D	0042802	molecular_function	identical protein binding
D	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
D	0045779	biological_process	negative regulation of bone resorption
D	0046872	molecular_function	metal ion binding
D	0048709	biological_process	oligodendrocyte differentiation
D	0050765	biological_process	negative regulation of phagocytosis
D	0050776	biological_process	regulation of immune response
D	0050860	biological_process	negative regulation of T cell receptor signaling pathway
D	0050868	biological_process	negative regulation of T cell activation
D	0051239	biological_process	regulation of multicellular organismal process
D	0060368	biological_process	regulation of Fc receptor mediated stimulatory signaling pathway
D	0070064	molecular_function	proline-rich region binding
D	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
D	0071375	biological_process	cellular response to peptide hormone stimulus
D	1990782	molecular_function	protein tyrosine kinase binding
E	0000166	molecular_function	nucleotide binding
E	0002250	biological_process	adaptive immune response
E	0002376	biological_process	immune system process
E	0004672	molecular_function	protein kinase activity
E	0004713	molecular_function	protein tyrosine kinase activity
E	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0005911	cellular_component	cell-cell junction
E	0006468	biological_process	protein phosphorylation
E	0008285	biological_process	negative regulation of cell population proliferation
E	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0019903	molecular_function	protein phosphatase binding
E	0032715	biological_process	negative regulation of interleukin-6 production
E	0034236	molecular_function	protein kinase A catalytic subunit binding
E	0034332	biological_process	adherens junction organization
E	0035556	biological_process	intracellular signal transduction
E	0042802	molecular_function	identical protein binding
E	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
E	0045779	biological_process	negative regulation of bone resorption
E	0046872	molecular_function	metal ion binding
E	0048709	biological_process	oligodendrocyte differentiation
E	0050765	biological_process	negative regulation of phagocytosis
E	0050776	biological_process	regulation of immune response
E	0050860	biological_process	negative regulation of T cell receptor signaling pathway
E	0050868	biological_process	negative regulation of T cell activation
E	0051239	biological_process	regulation of multicellular organismal process
E	0060368	biological_process	regulation of Fc receptor mediated stimulatory signaling pathway
E	0070064	molecular_function	proline-rich region binding
E	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
E	0071375	biological_process	cellular response to peptide hormone stimulus
E	1990782	molecular_function	protein tyrosine kinase binding
F	0000166	molecular_function	nucleotide binding
F	0002250	biological_process	adaptive immune response
F	0002376	biological_process	immune system process
F	0004672	molecular_function	protein kinase activity
F	0004713	molecular_function	protein tyrosine kinase activity
F	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0005911	cellular_component	cell-cell junction
F	0006468	biological_process	protein phosphorylation
F	0008285	biological_process	negative regulation of cell population proliferation
F	0010989	biological_process	negative regulation of low-density lipoprotein particle clearance
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0019903	molecular_function	protein phosphatase binding
F	0032715	biological_process	negative regulation of interleukin-6 production
F	0034236	molecular_function	protein kinase A catalytic subunit binding
F	0034332	biological_process	adherens junction organization
F	0035556	biological_process	intracellular signal transduction
F	0042802	molecular_function	identical protein binding
F	0042997	biological_process	negative regulation of Golgi to plasma membrane protein transport
F	0045779	biological_process	negative regulation of bone resorption
F	0046872	molecular_function	metal ion binding
F	0048709	biological_process	oligodendrocyte differentiation
F	0050765	biological_process	negative regulation of phagocytosis
F	0050776	biological_process	regulation of immune response
F	0050860	biological_process	negative regulation of T cell receptor signaling pathway
F	0050868	biological_process	negative regulation of T cell activation
F	0051239	biological_process	regulation of multicellular organismal process
F	0060368	biological_process	regulation of Fc receptor mediated stimulatory signaling pathway
F	0070064	molecular_function	proline-rich region binding
F	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
F	0071375	biological_process	cellular response to peptide hormone stimulus
F	1990782	molecular_function	protein tyrosine kinase binding

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGEFGDVMlGdyrgnk............VAVK

Chain	Residue	Details
A	ILE201-LYS222

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNVLV

Chain	Residue	Details
A	PHE310-VAL322

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	366
Details	Domain: {"description":"SH3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00192","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	445
Details	Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	366
Details	Region: {"description":"Interaction with PTPN22","evidences":[{"source":"UniProtKB","id":"P41240","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	54
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P41240","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P41240","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"P41240","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP314
A	ARG318

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP314
B	ARG318

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP314
C	ARG318

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP314
D	ARG318

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ASP314
E	ARG318

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ASP314
F	ARG318

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ALA316
A	ASP314

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ALA316
B	ASP314

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ALA316
C	ASP314

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ALA316
D	ASP314

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ALA316
E	ASP314

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ALA316
F	ASP314

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ALA316
A	ASN319
A	ASP314

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ALA316
B	ASN319
B	ASP314

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ALA316
C	ASN319
C	ASP314

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ALA316
D	ASN319
D	ASP314

site_id	CSA17
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
E	ALA316
E	ASN319
E	ASP314

site_id	CSA18
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
F	ALA316
F	ASN319
F	ASP314

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)