1K8T

Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0008294	molecular_function	calcium- and calmodulin-responsive adenylate cyclase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1001

Chain	Residue
A	HOH67
A	HOH71
A	LYS346
A	LYS353
A	SER354
A	LYS372

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1002

Chain	Residue
A	SER713
A	LYS716
A	GLN526
A	ILE711
A	PHE712

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	HOH85
A	LEU322
A	GLN507
A	TRP552

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1004

Chain	Residue
A	LYS753
A	ASN770
A	LYS774

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NI A 2001

Chain	Residue
A	HOH39
A	ASP491
A	ASP493
A	HIS577

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:11807546

Chain	Residue	Details
A	HIS351

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFU, ECO:0007744|PDB:1XFV, ECO:0007744|PDB:1XFW, ECO:0007744|PDB:1XFX, ECO:0007744|PDB:1XFY, ECO:0007744|PDB:1XFZ, ECO:0007744|PDB:1Y0V

Chain	Residue	Details
A	ASP491
A	ASP493
A	HIS577

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:15719022, ECO:0007744|PDB:1XFW

Chain	Residue	Details
A	THR548

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