1K78
Pax5(1-149)+Ets-1(331-440)+DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003677 | molecular_function | DNA binding |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
| I | 0003677 | molecular_function | DNA binding |
| I | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PROSITE/UniProt
| site_id | PS00034 |
| Number of Residues | 17 |
| Details | PAIRED_1 Paired DNA-binding domain signature. RPCdisrqlrvshgCVS |
| Chain | Residue | Details |
| A | ARG50-SER66 |
| site_id | PS00345 |
| Number of Residues | 9 |
| Details | ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL |
| Chain | Residue | Details |
| B | LEU337-LEU345 |
| site_id | PS00346 |
| Number of Residues | 16 |
| Details | ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY |
| Chain | Residue | Details |
| B | LYS381-TYR396 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 112 |
| Details | Region: {"description":"PAI subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU00381","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 96 |
| Details | Region: {"description":"RED subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU00381","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 160 |
| Details | DNA binding: {"description":"ETS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00237","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Region: {"description":"Helix H4","evidences":[{"source":"PubMed","id":"15591056","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Region: {"description":"Helix H5","evidences":[{"source":"PubMed","id":"15591056","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
