1K62
Crystal Structure of the Human Argininosuccinate Lyase Q286R Mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000050 | biological_process | urea cycle |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004056 | molecular_function | argininosuccinate lyase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0170033 | biological_process | L-amino acid metabolic process |
| B | 0000050 | biological_process | urea cycle |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004056 | molecular_function | argininosuccinate lyase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006525 | biological_process | arginine metabolic process |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042450 | biological_process | L-arginine biosynthetic process via ornithine |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0170033 | biological_process | L-amino acid metabolic process |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P24058","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P24058","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"description":"in chain A","evidences":[{"source":"UniProtKB","id":"P24058","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in chain C","evidences":[{"source":"UniProtKB","id":"P24058","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"in chain B","evidences":[{"source":"UniProtKB","id":"P24058","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Increases basicity of active site His","evidences":[{"source":"UniProtKB","id":"P24058","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"20167786","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q91YI0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | HIS160 | |
| A | THR159 | |
| B | SER281 | |
| B | LYS287 | |
| B | GLU294 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | SER281 | |
| A | LYS287 | |
| A | GLU294 | |
| B | HIS160 | |
| B | THR159 |
