1K62
Crystal Structure of the Human Argininosuccinate Lyase Q286R Mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000050 | biological_process | urea cycle |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004056 | molecular_function | argininosuccinate lyase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0007626 | biological_process | locomotory behavior |
| A | 0009791 | biological_process | post-embryonic development |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019676 | biological_process | ammonia assimilation cycle |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000050 | biological_process | urea cycle |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004056 | molecular_function | argininosuccinate lyase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006525 | biological_process | arginine metabolic process |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0007626 | biological_process | locomotory behavior |
| B | 0009791 | biological_process | post-embryonic development |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019676 | biological_process | ammonia assimilation cycle |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P24058 |
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:P24058 |
| Chain | Residue | Details |
| A | SER281 | |
| B | SER281 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: in chain A => ECO:0000250|UniProtKB:P24058 |
| Chain | Residue | Details |
| A | SER27 | |
| B | LYS329 | |
| A | ASN114 | |
| A | TYR321 | |
| A | GLN326 | |
| A | LYS329 | |
| B | SER27 | |
| B | ASN114 | |
| B | TYR321 | |
| B | GLN326 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: in chain C => ECO:0000250|UniProtKB:P24058 |
| Chain | Residue | Details |
| A | THR159 | |
| B | THR159 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: in chain B => ECO:0000250|UniProtKB:P24058 |
| Chain | Residue | Details |
| A | ASN289 | |
| B | ASN289 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Increases basicity of active site His => ECO:0000250|UniProtKB:P24058 |
| Chain | Residue | Details |
| A | GLU294 | |
| B | GLU294 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:Q91YI0 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q91YI0 |
| Chain | Residue | Details |
| A | LYS7 | |
| B | LYS7 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20167786 |
| Chain | Residue | Details |
| A | LYS69 | |
| A | LYS288 | |
| B | LYS69 | |
| B | LYS288 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | HIS160 | |
| A | THR159 | |
| B | SER281 | |
| B | LYS287 | |
| B | GLU294 |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1auw |
| Chain | Residue | Details |
| A | SER281 | |
| A | LYS287 | |
| A | GLU294 | |
| B | HIS160 | |
| B | THR159 |
