Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1K3F

Uridine Phosphorylase from E. coli, Refined in the Monoclinic Crystal Lattice

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006218	biological_process	uridine catabolic process
A	0006974	biological_process	DNA damage response
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0030955	molecular_function	potassium ion binding
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
A	0046050	biological_process	UMP catabolic process
A	0047847	molecular_function	deoxyuridine phosphorylase activity
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006218	biological_process	uridine catabolic process
B	0006974	biological_process	DNA damage response
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0030955	molecular_function	potassium ion binding
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
B	0046050	biological_process	UMP catabolic process
B	0047847	molecular_function	deoxyuridine phosphorylase activity
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006218	biological_process	uridine catabolic process
C	0006974	biological_process	DNA damage response
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0030955	molecular_function	potassium ion binding
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
C	0046050	biological_process	UMP catabolic process
C	0047847	molecular_function	deoxyuridine phosphorylase activity
D	0003824	molecular_function	catalytic activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006218	biological_process	uridine catabolic process
D	0006974	biological_process	DNA damage response
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0030955	molecular_function	potassium ion binding
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0044206	biological_process	UMP salvage
D	0046050	biological_process	UMP catabolic process
D	0047847	molecular_function	deoxyuridine phosphorylase activity
E	0003824	molecular_function	catalytic activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006218	biological_process	uridine catabolic process
E	0006974	biological_process	DNA damage response
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0030955	molecular_function	potassium ion binding
E	0032991	cellular_component	protein-containing complex
E	0042802	molecular_function	identical protein binding
E	0044206	biological_process	UMP salvage
E	0046050	biological_process	UMP catabolic process
E	0047847	molecular_function	deoxyuridine phosphorylase activity
F	0003824	molecular_function	catalytic activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006218	biological_process	uridine catabolic process
F	0006974	biological_process	DNA damage response
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0030955	molecular_function	potassium ion binding
F	0032991	cellular_component	protein-containing complex
F	0042802	molecular_function	identical protein binding
F	0044206	biological_process	UMP salvage
F	0046050	biological_process	UMP catabolic process
F	0047847	molecular_function	deoxyuridine phosphorylase activity

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER66-LEU81

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
A	GLU80
A	HIS8
A	ARG223

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
B	ARG1223
B	GLU1080
B	HIS1008

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
C	ARG2223
C	GLU2080
C	HIS2008

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
D	GLU3080
D	HIS3008
D	ARG3223

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
E	HIS4008
E	GLU4080
E	ARG4223

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1t0u

Chain	Residue	Details
F	GLU5080
F	ARG5223
F	HIS5008

site_id	MCSA1
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
A	LEU9	proton acceptor, proton donor
A	LEU81	electrostatic stabiliser, polar interaction
A	TYR169	proton acceptor, proton donor
A	THR224	electrostatic stabiliser, polar interaction

site_id	MCSA2
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
B	LEU1009	proton acceptor, proton donor
B	LEU1081	electrostatic stabiliser, polar interaction
B	TYR1169	proton acceptor, proton donor
B	THR1224	electrostatic stabiliser, polar interaction

site_id	MCSA3
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
C	LEU2009	proton acceptor, proton donor
C	LEU2081	electrostatic stabiliser, polar interaction
C	TYR2169	proton acceptor, proton donor
C	THR2224	electrostatic stabiliser, polar interaction

site_id	MCSA4
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
D	LEU3009	proton acceptor, proton donor
D	LEU3081	electrostatic stabiliser, polar interaction
D	TYR3169	proton acceptor, proton donor
D	THR3224	electrostatic stabiliser, polar interaction

site_id	MCSA5
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
E	LEU4009	proton acceptor, proton donor
E	LEU4081	electrostatic stabiliser, polar interaction
E	TYR4169	proton acceptor, proton donor
E	THR4224	electrostatic stabiliser, polar interaction

site_id	MCSA6
Number of Residues	4
Details	M-CSA 787

Chain	Residue	Details
F	LEU5009	proton acceptor, proton donor
F	LEU5081	electrostatic stabiliser, polar interaction
F	TYR5169	proton acceptor, proton donor
F	THR5224	electrostatic stabiliser, polar interaction

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)