1K0N

Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005254	molecular_function	chloride channel activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005903	cellular_component	brush border
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0031965	cellular_component	nuclear membrane
A	0031982	cellular_component	vesicle
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0034707	cellular_component	chloride channel complex
A	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
A	0045296	molecular_function	cadherin binding
A	0045669	biological_process	positive regulation of osteoblast differentiation
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051881	biological_process	regulation of mitochondrial membrane potential
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
A	1902476	biological_process	chloride transmembrane transport
B	0005254	molecular_function	chloride channel activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005783	cellular_component	endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0005903	cellular_component	brush border
B	0006811	biological_process	monoatomic ion transport
B	0006821	biological_process	chloride transport
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0031965	cellular_component	nuclear membrane
B	0031982	cellular_component	vesicle
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0034707	cellular_component	chloride channel complex
B	0045174	molecular_function	glutathione dehydrogenase (ascorbate) activity
B	0045296	molecular_function	cadherin binding
B	0045669	biological_process	positive regulation of osteoblast differentiation
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051881	biological_process	regulation of mitochondrial membrane potential
B	0070062	cellular_component	extracellular exosome
B	0070527	biological_process	platelet aggregation
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
B	1902476	biological_process	chloride transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GSH A 1001

Chain	Residue
A	LYS13
A	CYS24
A	PHE26
A	LEU64
A	ASP76
A	THR77

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	Transmembrane: {"description":"Helical; Note=After insertion into the membrane","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Motif: {"description":"G-site","evidences":[{"source":"PubMed","id":"25581026","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11551966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K0N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"S-glutathionyl cysteine; alternate","evidences":[{"source":"PubMed","id":"14613939","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9Z1Q5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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