1JYJ
Crystal Structure of a Double Variant (W67L/W91H) of Recombinant Human Serum Retinol-binding Protein at 2.0 A Resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001654 | biological_process | eye development |
| A | 0002639 | biological_process | positive regulation of immunoglobulin production |
| A | 0005501 | molecular_function | retinoid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0007507 | biological_process | heart development |
| A | 0007601 | biological_process | visual perception |
| A | 0016918 | molecular_function | retinal binding |
| A | 0019841 | molecular_function | retinol binding |
| A | 0030277 | biological_process | maintenance of gastrointestinal epithelium |
| A | 0030324 | biological_process | lung development |
| A | 0032024 | biological_process | positive regulation of insulin secretion |
| A | 0032526 | biological_process | response to retinoic acid |
| A | 0034632 | molecular_function | retinol transmembrane transporter activity |
| A | 0034633 | biological_process | retinol transport |
| A | 0042572 | biological_process | retinol metabolic process |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0048562 | biological_process | embryonic organ morphogenesis |
| A | 0048706 | biological_process | embryonic skeletal system development |
| A | 0048738 | biological_process | cardiac muscle tissue development |
| A | 0048807 | biological_process | female genitalia morphogenesis |
| A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
| A | 0060059 | biological_process | embryonic retina morphogenesis in camera-type eye |
| A | 0060065 | biological_process | uterus development |
| A | 0060068 | biological_process | vagina development |
| A | 0060157 | biological_process | urinary bladder development |
| A | 0060347 | biological_process | heart trabecula formation |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 500 |
| Chain | Residue |
| A | LYS29 |
| A | HOH531 |
| A | PRO32 |
| A | LEU35 |
| A | PHE36 |
| A | LEU37 |
| A | ARG121 |
| A | TYR133 |
| A | PHE135 |
| A | GOL501 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 501 |
| Chain | Residue |
| A | MET73 |
| A | TYR90 |
| A | GOL500 |
| A | GOL502 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | PHE45 |
| A | ALA55 |
| A | PHE135 |
| A | PHE137 |
| A | GOL501 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 503 |
| Chain | Residue |
| A | THR23 |
| A | GLU49 |
| A | HOH550 |
| A | HOH574 |
| A | HOH681 |
| A | HOH686 |
| A | HOH692 |
| A | HOH693 |
| A | HOH694 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GOL A 504 |
| Chain | Residue |
| A | LYS30 |
| A | CYS129 |
| A | ALA130 |
| A | ASP131 |
| A | SER132 |
| A | LEU161 |
| A | GLN164 |
| A | HOH509 |
| A | HOH512 |
| A | HOH518 |
| A | HOH589 |
| A | HOH613 |
Functional Information from PROSITE/UniProt
| site_id | PS00213 |
| Number of Residues | 14 |
| Details | LIPOCALIN Lipocalin signature. NFDkaRFSGTWYAM |
| Chain | Residue | Details |
| A | ASN14-MET27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P27485 |
| Chain | Residue | Details |
| A | GLY100 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q00724 |
| Chain | Residue | Details |
| A | LEU123 |
