1JWH
Crystal Structure of Human Protein Kinase CK2 Holoenzyme
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006468 | biological_process | protein phosphorylation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006468 | biological_process | protein phosphorylation |
C | 0000785 | cellular_component | chromatin |
C | 0003682 | molecular_function | chromatin binding |
C | 0004674 | molecular_function | protein serine/threonine kinase activity |
C | 0005102 | molecular_function | signaling receptor binding |
C | 0005515 | molecular_function | protein binding |
C | 0005576 | cellular_component | extracellular region |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0005956 | cellular_component | protein kinase CK2 complex |
C | 0007165 | biological_process | signal transduction |
C | 0008285 | biological_process | negative regulation of cell population proliferation |
C | 0016055 | biological_process | Wnt signaling pathway |
C | 0016605 | cellular_component | PML body |
C | 0018107 | biological_process | peptidyl-threonine phosphorylation |
C | 0019887 | molecular_function | protein kinase regulator activity |
C | 0019904 | molecular_function | protein domain specific binding |
C | 0030674 | molecular_function | protein-macromolecule adaptor activity |
C | 0031519 | cellular_component | PcG protein complex |
C | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
C | 0032927 | biological_process | positive regulation of activin receptor signaling pathway |
C | 0033211 | biological_process | adiponectin-activated signaling pathway |
C | 0034774 | cellular_component | secretory granule lumen |
C | 0042802 | molecular_function | identical protein binding |
C | 0043537 | biological_process | negative regulation of blood vessel endothelial cell migration |
C | 0046872 | molecular_function | metal ion binding |
C | 0051101 | biological_process | regulation of DNA binding |
C | 0060391 | biological_process | positive regulation of SMAD protein signal transduction |
C | 0061154 | biological_process | endothelial tube morphogenesis |
C | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
C | 0065003 | biological_process | protein-containing complex assembly |
C | 0070062 | cellular_component | extracellular exosome |
C | 0075342 | biological_process | symbiont-mediated disruption of host cell PML body |
C | 1903901 | biological_process | negative regulation of viral life cycle |
C | 1904813 | cellular_component | ficolin-1-rich granule lumen |
D | 0000785 | cellular_component | chromatin |
D | 0003682 | molecular_function | chromatin binding |
D | 0004674 | molecular_function | protein serine/threonine kinase activity |
D | 0005102 | molecular_function | signaling receptor binding |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005886 | cellular_component | plasma membrane |
D | 0005956 | cellular_component | protein kinase CK2 complex |
D | 0007165 | biological_process | signal transduction |
D | 0008285 | biological_process | negative regulation of cell population proliferation |
D | 0016055 | biological_process | Wnt signaling pathway |
D | 0016605 | cellular_component | PML body |
D | 0018107 | biological_process | peptidyl-threonine phosphorylation |
D | 0019887 | molecular_function | protein kinase regulator activity |
D | 0019904 | molecular_function | protein domain specific binding |
D | 0030674 | molecular_function | protein-macromolecule adaptor activity |
D | 0031519 | cellular_component | PcG protein complex |
D | 0032435 | biological_process | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
D | 0032927 | biological_process | positive regulation of activin receptor signaling pathway |
D | 0033211 | biological_process | adiponectin-activated signaling pathway |
D | 0034774 | cellular_component | secretory granule lumen |
D | 0042802 | molecular_function | identical protein binding |
D | 0043537 | biological_process | negative regulation of blood vessel endothelial cell migration |
D | 0046872 | molecular_function | metal ion binding |
D | 0051101 | biological_process | regulation of DNA binding |
D | 0060391 | biological_process | positive regulation of SMAD protein signal transduction |
D | 0061154 | biological_process | endothelial tube morphogenesis |
D | 0061629 | molecular_function | RNA polymerase II-specific DNA-binding transcription factor binding |
D | 0065003 | biological_process | protein-containing complex assembly |
D | 0070062 | cellular_component | extracellular exosome |
D | 0075342 | biological_process | symbiont-mediated disruption of host cell PML body |
D | 1903901 | biological_process | negative regulation of viral life cycle |
D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 A 350 |
Chain | Residue |
A | HIS234 |
A | ARG244 |
A | HOH394 |
A | HOH397 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE PO4 B 351 |
Chain | Residue |
B | ARG244 |
B | HOH365 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 B 352 |
Chain | Residue |
B | HOH375 |
B | ARG195 |
B | LYS198 |
B | ASN238 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PO4 C 353 |
Chain | Residue |
C | LYS147 |
C | SER148 |
C | ARG150 |
C | HOH358 |
C | HOH366 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PO4 D 354 |
Chain | Residue |
D | ARG17 |
D | SER148 |
D | SER149 |
D | PO4355 |
D | HOH359 |
D | HOH364 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 D 355 |
Chain | Residue |
C | GLU57 |
D | LYS147 |
D | ARG150 |
D | PO4354 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PO4 D 356 |
Chain | Residue |
D | GLU20 |
D | LYS100 |
D | ASP105 |
D | HOH361 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN C 357 |
Chain | Residue |
C | CYS109 |
C | CYS114 |
C | CYS137 |
C | CYS140 |
C | TYR144 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN D 358 |
Chain | Residue |
D | CYS109 |
D | CYS114 |
D | CYS137 |
D | CYS140 |
D | TYR144 |
site_id | BC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE ANP A 340 |
Chain | Residue |
A | SER51 |
A | VAL66 |
A | LYS68 |
A | GLU114 |
A | VAL116 |
A | HIS160 |
A | MET163 |
A | ASP175 |
A | HOH384 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnek..........VVVK |
Chain | Residue | Details |
A | LEU45-LYS68 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
Chain | Residue | Details |
A | ILE152-ILE164 |
site_id | PS01101 |
Number of Residues | 32 |
Details | CK2_BETA Casein kinase II regulatory subunit signature. CPrVyCenqpmLPIGlsdipgeamVKlyCPkC |
Chain | Residue | Details |
C | CYS109-CYS140 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: |
Chain | Residue | Details |
C | CYS109 | |
C | CYS114 | |
C | CYS137 | |
C | CYS140 | |
D | CYS109 | |
D | CYS114 | |
D | CYS137 | |
D | CYS140 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:11574463 |
Chain | Residue | Details |
C | SER2 | |
C | SER3 | |
D | SER2 | |
D | SER3 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
Chain | Residue | Details |
C | SER8 | |
C | SER69 | |
D | SER8 | |
D | SER69 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
C | THR37 | |
D | THR37 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
C | SER209 | |
D | SER209 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
C | LYS212 | |
D | LYS212 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297 |
Chain | Residue | Details |
C | LYS212 | |
D | LYS212 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP156 | |
A | HIS160 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASP156 | |
B | HIS160 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP156 | |
A | LYS158 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASP156 | |
B | LYS158 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP156 | |
A | LYS158 | |
A | SER194 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASP156 | |
B | LYS158 | |
B | SER194 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP156 | |
A | ASN161 | |
A | LYS158 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASP156 | |
B | ASN161 | |
B | LYS158 |