Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0031427 | biological_process | response to methotrexate |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NDP A 194 |
| Chain | Residue |
| A | PHE6 |
| A | ALA53 |
| A | LYS54 |
| A | THR55 |
| A | CYS72 |
| A | ASP73 |
| A | ARG76 |
| A | ASP77 |
| A | PRO79 |
| A | GLY128 |
| A | GLY129 |
| A | ARG7 |
| A | PRO130 |
| A | HOH199 |
| A | HOH224 |
| A | HOH251 |
| A | HOH257 |
| A | HOH289 |
| A | HOH295 |
| A | PHE22 |
| A | GLY23 |
| A | LEU24 |
| A | GLY25 |
| A | GLY27 |
| A | TRP30 |
| A | GLY52 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. AFGlgdgLPWgrvkkDlqnFkarT |
| Chain | Residue | Details |
| A | ALA21-THR44 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG7 | |
| A | PHE22 | |
| A | GLY52 | |
| A | ASP73 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | LEU28 | |
| A | ASP36 | |
