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1JSY

Crystal structure of bovine arrestin-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000822molecular_functioninositol hexakisphosphate binding
A0001664molecular_functionG protein-coupled receptor binding
A0001934biological_processpositive regulation of protein phosphorylation
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0005515molecular_functionprotein binding
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006511biological_processubiquitin-dependent protein catabolic process
A0007165biological_processsignal transduction
A0007601biological_processvisual perception
A0009968biological_processnegative regulation of signal transduction
A0015031biological_processprotein transport
A0030132cellular_componentclathrin coat of coated pit
A0030276molecular_functionclathrin binding
A0031143cellular_componentpseudopodium
A0031410cellular_componentcytoplasmic vesicle
A0031623biological_processreceptor internalization
A0032050molecular_functionclathrin heavy chain binding
A0033130molecular_functionacetylcholine receptor binding
A0035612molecular_functionAP-2 adaptor complex binding
A0036094molecular_functionsmall molecule binding
A0042995cellular_componentcell projection
A0045746biological_processnegative regulation of Notch signaling pathway
A0060090molecular_functionmolecular adaptor activity
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072583biological_processclathrin-dependent endocytosis
Functional Information from PROSITE/UniProt
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLtFrKDL
ChainResidueDetails
APHE61-LEU79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
ALYS250
AMET255
ALYS324
ALYS326

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8BWG8
ChainResidueDetails
ATYR47

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by GRK5 => ECO:0000250|UniProtKB:P49407
ChainResidueDetails
ASER412

221716

PDB entries from 2024-06-26

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