1JS3
Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004058 | molecular_function | aromatic-L-amino-acid decarboxylase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0006584 | biological_process | catecholamine metabolic process |
A | 0016830 | molecular_function | carbon-carbon lyase activity |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0036467 | molecular_function | 5-hydroxy-L-tryptophan decarboxylase activity |
A | 0036468 | molecular_function | L-dopa decarboxylase activity |
A | 0042416 | biological_process | dopamine biosynthetic process |
A | 0042423 | biological_process | catecholamine biosynthetic process |
A | 0042427 | biological_process | serotonin biosynthetic process |
B | 0004058 | molecular_function | aromatic-L-amino-acid decarboxylase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006520 | biological_process | amino acid metabolic process |
B | 0006584 | biological_process | catecholamine metabolic process |
B | 0016830 | molecular_function | carbon-carbon lyase activity |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0036467 | molecular_function | 5-hydroxy-L-tryptophan decarboxylase activity |
B | 0036468 | molecular_function | L-dopa decarboxylase activity |
B | 0042416 | biological_process | dopamine biosynthetic process |
B | 0042423 | biological_process | catecholamine biosynthetic process |
B | 0042427 | biological_process | serotonin biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 801 |
Chain | Residue |
A | ASN2 |
A | ALA3 |
B | TYR86 |
B | ARG453 |
B | LYS454 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 802 |
Chain | Residue |
B | ALA3 |
A | TYR86 |
A | ARG453 |
A | LYS454 |
B | ASN2 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 803 |
Chain | Residue |
A | ARG347 |
A | HIS348 |
B | HOH941 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 B 804 |
Chain | Residue |
B | ARG347 |
B | HIS348 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE PLP A 601 |
Chain | Residue |
A | SER147 |
A | ALA148 |
A | SER149 |
A | HIS192 |
A | SER194 |
A | THR246 |
A | ASP271 |
A | ALA273 |
A | ASN300 |
A | HIS302 |
A | LYS303 |
A | 142701 |
A | HOH805 |
A | HOH908 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE PLP B 602 |
Chain | Residue |
B | SER147 |
B | ALA148 |
B | SER149 |
B | HIS192 |
B | SER194 |
B | THR246 |
B | ASP271 |
B | ALA273 |
B | ASN300 |
B | HIS302 |
B | LYS303 |
B | 142702 |
B | HOH959 |
B | HOH987 |
site_id | AC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 142 A 701 |
Chain | Residue |
A | TYR79 |
A | PHE80 |
A | PRO81 |
A | THR82 |
A | HIS192 |
A | HIS302 |
A | LYS303 |
A | PLP601 |
A | HOH1001 |
A | HOH1003 |
site_id | AC8 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE 142 B 702 |
Chain | Residue |
B | TYR79 |
B | PHE80 |
B | PRO81 |
B | THR82 |
B | HIS192 |
B | THR246 |
B | HIS302 |
B | LYS303 |
B | PLP602 |
B | HOH1022 |
Functional Information from PROSITE/UniProt
site_id | PS00392 |
Number of Residues | 22 |
Details | DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFnFnphKWLlVnFDCsaMWvK |
Chain | Residue | Details |
A | SER296-LYS317 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11685243, ECO:0007744|PDB:1JS3 |
Chain | Residue | Details |
A | THR82 | |
A | HIS192 | |
B | THR82 | |
B | HIS192 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P20711 |
Chain | Residue | Details |
A | ALA148 | |
A | SER149 | |
A | THR246 | |
A | ASN300 | |
B | ALA148 | |
B | SER149 | |
B | THR246 | |
B | ASN300 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:1935935 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:11685243 |
Chain | Residue | Details |
A | LYS303 | |
B | LYS303 |