1JS0

Crystal Structure of 3D Domain-swapped RNase A Minor Trimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004519	molecular_function	endonuclease activity
A	0004522	molecular_function	ribonuclease A activity
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0016829	molecular_function	lyase activity
A	0050830	biological_process	defense response to Gram-positive bacterium
B	0003676	molecular_function	nucleic acid binding
B	0004519	molecular_function	endonuclease activity
B	0004522	molecular_function	ribonuclease A activity
B	0004540	molecular_function	RNA nuclease activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0016829	molecular_function	lyase activity
B	0050830	biological_process	defense response to Gram-positive bacterium
C	0003676	molecular_function	nucleic acid binding
C	0004519	molecular_function	endonuclease activity
C	0004522	molecular_function	ribonuclease A activity
C	0004540	molecular_function	RNA nuclease activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0016829	molecular_function	lyase activity
C	0050830	biological_process	defense response to Gram-positive bacterium

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 601

Chain	Residue
B	GLN11
B	HIS12
B	LYS41
B	HOH1110
B	HOH1169
B	HOH1178
C	VAL118
C	HIS119
C	PHE120

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 602

Chain	Residue
A	GLN11
A	HIS12
A	LYS41
B	VAL118
B	HIS119
B	PHE120
B	HOH1033

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 603

Chain	Residue
A	VAL118
A	HIS119
A	PHE120
A	HOH1109
C	GLN11
C	HIS12
C	LYS41

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE SO4 A 604

Chain	Residue
A	GLU111
A	GLY112
A	TYR115
A	HOH1003
A	HOH1031
A	HOH1145
B	GLU111
B	GLY112
B	TYR115
C	GLU111
C	GLY112
C	TYR115

---

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKpvNTF

Chain	Residue	Details
A	CYS40-PHE46

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	HIS12
B	HIS12
C	HIS12

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	HIS119
B	HIS119
C	HIS119

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	BINDING:

Chain	Residue	Details
A	LYS7
B	ARG85
C	LYS7
C	ARG10
C	LYS41
C	LYS66
C	ARG85
A	ARG10
A	LYS41
A	LYS66
A	ARG85
B	LYS7
B	ARG10
B	LYS41
B	LYS66

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:4030761

Chain	Residue	Details
A	LYS1
C	LYS7
C	LYS37
C	LYS41
A	LYS7
A	LYS37
A	LYS41
B	LYS1
B	LYS7
B	LYS37
B	LYS41
C	LYS1

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:19358553

Chain	Residue	Details
A	ASN34
B	ASN34
C	ASN34

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
A	PHE120
A	HIS119
A	HIS12
A	LYS41

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
B	PHE120
B	HIS119
B	HIS12
B	LYS41

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
C	PHE120
C	HIS119
C	HIS12
C	LYS41

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
A	HIS119
A	HIS12
A	LYS41

---

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
B	HIS119
B	HIS12
B	LYS41

---

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1rbn

Chain	Residue	Details
C	HIS119
C	HIS12
C	LYS41

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 164

Chain	Residue	Details
A	HIS12	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	LYS41	electrostatic stabiliser, hydrogen bond donor
A	HIS119	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	PHE120	electrostatic stabiliser, hydrogen bond donor
A	ASP121	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 164

Chain	Residue	Details
B	HIS12	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	LYS41	electrostatic stabiliser, hydrogen bond donor
B	HIS119	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
B	PHE120	electrostatic stabiliser, hydrogen bond donor
B	ASP121	electrostatic stabiliser, hydrogen bond acceptor

---

site_id	MCSA3
Number of Residues	5
Details	M-CSA 164

Chain	Residue	Details
C	HIS12	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	LYS41	electrostatic stabiliser, hydrogen bond donor
C	HIS119	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
C	PHE120	electrostatic stabiliser, hydrogen bond donor
C	ASP121	electrostatic stabiliser, hydrogen bond acceptor

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