1JPH
Ile260Thr mutant of Human UroD, human uroporphyrinogen III decarboxylase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004853 | molecular_function | uroporphyrinogen decarboxylase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006778 | biological_process | porphyrin-containing compound metabolic process |
A | 0006779 | biological_process | porphyrin-containing compound biosynthetic process |
A | 0006782 | biological_process | protoporphyrinogen IX biosynthetic process |
A | 0006783 | biological_process | heme biosynthetic process |
A | 0006784 | biological_process | heme A biosynthetic process |
A | 0006785 | biological_process | heme B biosynthetic process |
A | 0006787 | biological_process | porphyrin-containing compound catabolic process |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0042168 | biological_process | heme metabolic process |
A | 0048034 | biological_process | heme O biosynthetic process |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 7 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG37 | |
A | PHE55 | |
A | SER85 | |
A | ASP86 | |
A | TYR164 | |
A | SER219 | |
A | HIS339 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
A | ASP86 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | MET1 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1uro |
Chain | Residue | Details |
A | TYR164 | |
A | ASP86 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 914 |
Chain | Residue | Details |
A | ARG37 | proton shuttle (general acid/base) |
A | ARG41 | electrostatic stabiliser |
A | ARG50 | proton shuttle (general acid/base) |
A | ASP86 | enhance reactivity, modifies pKa, transition state stabiliser |
A | TYR164 | electrostatic stabiliser |