1JP4

Crystal Structure of an Enzyme Displaying both Inositol-Polyphosphate 1-Phosphatase and 3'-Phosphoadenosine-5'-Phosphate Phosphatase Activities

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004441	molecular_function	inositol-1,4-bisphosphate 1-phosphatase activity
A	0008150	biological_process	biological_process
A	0008441	molecular_function	3'(2'),5'-bisphosphate nucleotidase activity
A	0016787	molecular_function	hydrolase activity
A	0046854	biological_process	phosphatidylinositol phosphate biosynthetic process
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PO4 A 501

Chain	Residue
A	ASP51
A	MG702
A	MG703
A	HOH812
A	HOH840
A	HOH929
A	HOH1216
A	HOH1218
A	HOH1219
A	GLU74
A	ASP117
A	VAL119
A	ASP120
A	GLY121
A	THR122
A	AMP601
A	MG701

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 701

Chain	Residue
A	ASP117
A	ASP120
A	ASP247
A	PO4501
A	AMP601
A	MG702
A	HOH840

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 702

Chain	Residue
A	GLU74
A	ASP117
A	VAL119
A	PO4501
A	MG701
A	HOH811

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 703

Chain	Residue
A	GLU74
A	PO4501
A	HOH929
A	HOH1216
A	HOH1217
A	HOH1218
A	HOH1219

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE AMP A 601

Chain	Residue
A	ASP120
A	THR195
A	HIS198
A	GLY219
A	GLY220
A	LYS224
A	PHE238
A	GLY242
A	CYS243
A	ASP247
A	PO4501
A	MG701
A	HOH828
A	HOH840
A	HOH853
A	HOH900
A	HOH929

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME A 801

Chain	Residue
A	GLN55
A	CYS59
A	ILE71
A	GLY73
A	HOH916
A	HOH1117

---

Functional Information from PROSITE/UniProt

site_id	PS00629
Number of Residues	13
Details	IMP_1 Inositol monophosphatase family signature 1. VwVDPVDGTkeY.T

Chain	Residue	Details
A	VAL114-THR126

---

site_id	PS00630
Number of Residues	15
Details	IMP_2 Inositol monophosphatase family signature 2. WDtCAPeVILhavGG

Chain	Residue	Details
A	TRP246-GLY260

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:11812139

Chain	Residue	Details
A	ASP51
A	THR122

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:11812139, ECO:0007744|PDB:1JP4

Chain	Residue	Details
A	GLU74
A	ASP117
A	VAL119
A	ASP120
A	THR195
A	HIS198
A	GLY220
A	LYS224
A	ASP247

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.4

Chain	Residue	Details
A	ALA2

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:O95861

Chain	Residue	Details
A	THR122

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O95861

Chain	Residue	Details
A	SER240

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9Z0S1

Chain	Residue	Details
A	LYS244

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
A	GLU74
A	THR122

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1ima

Chain	Residue	Details
A	ASP51
A	THR122
A	ASP247

---