Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1JM6

Pyruvate dehydrogenase kinase, isozyme 2, containing ADP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0006111biological_processregulation of gluconeogenesis
A0006885biological_processregulation of pH
A0008286biological_processinsulin receptor signaling pathway
A0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
A0010565biological_processregulation of cellular ketone metabolic process
A0010906biological_processregulation of glucose metabolic process
A0016301molecular_functionkinase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0031670biological_processcellular response to nutrient
A0034614biological_processcellular response to reactive oxygen species
A0042593biological_processglucose homeostasis
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0044877molecular_functionprotein-containing complex binding
A0045254cellular_componentpyruvate dehydrogenase complex
A0050848biological_processregulation of calcium-mediated signaling
A0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004740molecular_functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0006111biological_processregulation of gluconeogenesis
B0006885biological_processregulation of pH
B0008286biological_processinsulin receptor signaling pathway
B0010510biological_processregulation of acetyl-CoA biosynthetic process from pyruvate
B0010565biological_processregulation of cellular ketone metabolic process
B0010906biological_processregulation of glucose metabolic process
B0016301molecular_functionkinase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0031670biological_processcellular response to nutrient
B0034614biological_processcellular response to reactive oxygen species
B0042593biological_processglucose homeostasis
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0044877molecular_functionprotein-containing complex binding
B0045254cellular_componentpyruvate dehydrogenase complex
B0050848biological_processregulation of calcium-mediated signaling
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 4601
ChainResidue
AASN1247
AADP3500
AHOH4602
AHOH4603

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 4611
ChainResidue
BASN1247
BADP3510
BHOH6003
BHOH6004

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE ADP A 3500
ChainResidue
AARG1250
AALA1251
AASP1282
AVAL1287
ALEU1295
ASER1301
ATHR1302
AGLY1317
APHE1318
AGLY1319
AGLY1321
ALEU1322
ATHR1346
AMG4601
AHOH4603
AHOH6050
AHOH6098
AASN1247

site_idAC4
Number of Residues19
DetailsBINDING SITE FOR RESIDUE ADP B 3510
ChainResidue
BASN1247
BARG1250
BALA1251
BASP1282
BVAL1287
BLEU1295
BSER1301
BTHR1302
BALA1316
BGLY1317
BPHE1318
BGLY1319
BGLY1321
BLEU1322
BTHR1346
BMG4611
BHOH6004
BHOH6006
BHOH6060

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AGLU1243
AASP1282
ASER1301
AGLY1317
BGLU1243
BASP1282
BSER1301
BGLY1317

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q15118
ChainResidueDetails
ATYR1207
ATYR1208
BTYR1207
BTYR1208

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BFP9
ChainResidueDetails
ALYS1368
BLYS1368

Catalytic Information from CSA
site_idCSA1
Number of Residues2
Detailsa catalytic site defined by CSA, PubMed 11483605, 11278487
ChainResidueDetails
AHIS1239
AGLU1243

site_idCSA2
Number of Residues2
Detailsa catalytic site defined by CSA, PubMed 11483605, 11278487
ChainResidueDetails
AHIS1239
AGLU1243

site_idMCSA1
Number of Residues4
DetailsM-CSA 603
ChainResidueDetails
AHIS1239electrostatic stabiliser
AGLU1243metal ligand, proton shuttle (general acid/base)
ALYS1246metal ligand
AASN1247metal ligand

site_idMCSA2
Number of Residues4
DetailsM-CSA 603
ChainResidueDetails
BHIS1239electrostatic stabiliser
BGLU1243metal ligand, proton shuttle (general acid/base)
BLYS1246metal ligand
BASN1247metal ligand

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon