1JLS

STRUCTURE OF THE URACIL PHOSPHORIBOSYLTRANSFERASE URACIL/CPR 2 MUTANT C128V

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004845	molecular_function	uracil phosphoribosyltransferase activity
A	0005525	molecular_function	GTP binding
A	0008655	biological_process	pyrimidine-containing compound salvage
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0044206	biological_process	UMP salvage
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004845	molecular_function	uracil phosphoribosyltransferase activity
B	0005525	molecular_function	GTP binding
B	0008655	biological_process	pyrimidine-containing compound salvage
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0044206	biological_process	UMP salvage
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004845	molecular_function	uracil phosphoribosyltransferase activity
C	0005525	molecular_function	GTP binding
C	0008655	biological_process	pyrimidine-containing compound salvage
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0044206	biological_process	UMP salvage
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004845	molecular_function	uracil phosphoribosyltransferase activity
D	0005525	molecular_function	GTP binding
D	0008655	biological_process	pyrimidine-containing compound salvage
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0044206	biological_process	UMP salvage

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9628859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BD3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UPU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11773618","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JLR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11773618","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JLS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11773618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9628859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BD3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BD4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JLR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UPU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11773618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9628859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BD3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1BD4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JLR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JLS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11773618","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9628859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JLS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UPU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9628859","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1UPU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11773618","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1JLR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JLS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
B	THR141
B	ARG137
B	ASP235

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
A	ARG137
A	ASP235

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
D	ARG137
D	ASP235

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bd3

Chain	Residue	Details
C	THR141
C	ARG137
C	ASP235

---

site_id	MCSA1
Number of Residues	4
Details	M-CSA 420

Chain	Residue	Details
A	ARG137	electrostatic stabiliser
A	THR141	electrostatic stabiliser
A	ASP235	electrostatic stabiliser
A	ASP238	modifies pKa

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 420

Chain	Residue	Details
B	ARG137	electrostatic stabiliser
B	ASP235	electrostatic stabiliser
B	ASP238	modifies pKa

---

site_id	MCSA3
Number of Residues	3
Details	M-CSA 420

Chain	Residue	Details
C	ARG137	electrostatic stabiliser
C	ASP235	electrostatic stabiliser
C	ASP238	modifies pKa

---

site_id	MCSA4
Number of Residues	4
Details	M-CSA 420

Chain	Residue	Details
D	ARG137	electrostatic stabiliser
D	THR141	electrostatic stabiliser
D	ASP235	electrostatic stabiliser
D	ASP238	modifies pKa

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