1JLN

Crystal structure of the catalytic domain of protein tyrosine phosphatase PTP-SL/BR7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
A	VAL478-GLY488

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044

Chain	Residue	Details
A	CYS480

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP446
A	CYS480
A	GLN524

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	THR271

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:10601328

Chain	Residue	Details
A	TYR338

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	GLU388
A	CYS480
A	HIS479
A	THR487
A	ASP446
A	ARG486

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	CYS480
A	THR487
A	ARG486
A	ASP446

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