1JEB

Chimeric Human/Mouse Carbonmonoxy Hemoglobin (Human Zeta2 / Mouse Beta2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005833	cellular_component	hemoglobin complex
B	0010999	biological_process	regulation of eIF2 alpha phosphorylation by heme
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030097	biological_process	hemopoiesis
B	0030185	biological_process	nitric oxide transport
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031722	molecular_function	hemoglobin beta binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0043209	cellular_component	myelin sheath
B	0044877	molecular_function	protein-containing complex binding
B	0046872	molecular_function	metal ion binding
B	0048821	biological_process	erythrocyte development
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005833	cellular_component	hemoglobin complex
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005833	cellular_component	hemoglobin complex
D	0010999	biological_process	regulation of eIF2 alpha phosphorylation by heme
D	0015670	biological_process	carbon dioxide transport
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0030097	biological_process	hemopoiesis
D	0030185	biological_process	nitric oxide transport
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031722	molecular_function	hemoglobin beta binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0043209	cellular_component	myelin sheath
D	0044877	molecular_function	protein-containing complex binding
D	0046872	molecular_function	metal ion binding
D	0048821	biological_process	erythrocyte development
D	0072562	cellular_component	blood microparticle
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE HEM A 142

Chain	Residue
A	TYR42
A	LEU91
A	VAL93
A	ASN97
A	PHE98
A	LEU101
A	LEU136
A	CMO143
A	PHE43
A	HIS45
A	PHE46
A	HIS58
A	LYS61
A	ALA65
A	LEU83
A	HIS87

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO A 143

Chain	Residue
A	HIS58
A	VAL62
A	HEM142

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM B 147

Chain	Residue
B	THR38
B	TYR41
B	PHE45
B	HIS63
B	ALA70
B	LEU88
B	LEU91
B	HIS92
B	LEU96
B	VAL98
B	ASN102
B	PHE103
B	LEU106
B	LEU141
B	CMO148

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO B 148

Chain	Residue
B	HIS63
B	VAL67
B	HEM147

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE HEM C 142

Chain	Residue
B	HIS77
C	TYR42
C	PHE43
C	HIS45
C	PHE46
C	HIS58
C	LYS61
C	LEU86
C	HIS87
C	LEU91
C	VAL93
C	ASN97
C	PHE98
C	LEU101
C	CMO143

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO C 143

Chain	Residue
C	HIS58
C	VAL62
C	HEM142

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM D 147

Chain	Residue
D	TYR41
D	PHE42
D	PHE45
D	HIS63
D	LYS66
D	LEU88
D	LEU91
D	HIS92
D	LEU96
D	VAL98
D	ASN102
D	LEU106
D	LEU141
D	CMO148

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CMO D 148

Chain	Residue
D	HIS63
D	VAL67
D	HEM147

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: distal binding residue => ECO:0000250|UniProtKB:P80044

Chain	Residue	Details
B	GLY64
D	GLY64

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: proximal binding residue => ECO:0000269|PubMed:11747442, ECO:0007744|PDB:1JEB, ECO:0007744|PDB:3HRW

Chain	Residue	Details
B	CYS93
D	CYS93

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylvaline => ECO:0000250|UniProtKB:P02086

Chain	Residue	Details
B	HIS2
D	HIS2

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
B	VAL18
D	VAL18

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:21183079

Chain	Residue	Details
B	ASP21
D	ASP21
A	LYS82
C	ALA53
C	ILE73
C	LYS82

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02091

Chain	Residue	Details
D	PHE45
D	ALA51
B	PHE45
B	ALA51

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P02089

Chain	Residue	Details
B	VAL60
D	VAL60

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Asymmetric dimethylarginine => ECO:0000250|UniProtKB:P02089

Chain	Residue	Details
B	LEU105
D	LEU105

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P11517

Chain	Residue	Details
B	PRO124
D	PRO124

---