1J53

Structure of the N-terminal Exonuclease Domain of the Epsilon Subunit of E.coli DNA Polymerase III at pH 8.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006260	biological_process	DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 3000

Chain	Residue
A	ASP12
A	GLU14
A	ASP167
A	TMP2000
A	HOH5002

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 3001

Chain	Residue
A	HOH5146
A	ASP12
A	TMP2000
A	HOH5040
A	HOH5145

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site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE TMP A 2000

Chain	Residue
A	ASP12
A	THR13
A	GLU14
A	THR15
A	MET18
A	GLU61
A	VAL65
A	HIS66
A	PHE102
A	HIS162
A	ASP167
A	MN3000
A	MN3001
A	HOH5002
A	HOH5137

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 4000

Chain	Residue
A	THR123

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 5000

Chain	Residue
A	ARG7
A	GLN8
A	VAL38
A	VAL39

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	a catalytic site defined by CSA, PubMed 11937058

Chain	Residue	Details
A	GLU61
A	GLU14

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 754

Chain	Residue	Details
A	ASP12	metal ligand
A	GLU14	hydrogen bond acceptor, metal ligand, proton acceptor, proton donor
A	GLU61	electrostatic stabiliser, increase basicity, polar interaction
A	HIS162	proton acceptor, proton donor
A	ASP167	metal ligand

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