1J4X

HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE C124S MUTANT-PEPTIDE COMPLEX

Replaces:  1F5D

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001772	cellular_component	immunological synapse
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006470	biological_process	protein dephosphorylation
A	0008092	molecular_function	cytoskeletal protein binding
A	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
A	0016311	biological_process	dephosphorylation
A	0016791	molecular_function	phosphatase activity
A	0017018	molecular_function	myosin phosphatase activity
A	0019901	molecular_function	protein kinase binding
A	0030336	biological_process	negative regulation of cell migration
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0033549	molecular_function	MAP kinase phosphatase activity
A	0035335	biological_process	peptidyl-tyrosine dephosphorylation
A	0042059	biological_process	negative regulation of epidermal growth factor receptor signaling pathway
A	0043409	biological_process	negative regulation of MAPK cascade
A	0045931	biological_process	positive regulation of mitotic cell cycle
A	0046329	biological_process	negative regulation of JNK cascade
A	0050860	biological_process	negative regulation of T cell receptor signaling pathway
A	0050868	biological_process	negative regulation of T cell activation
A	0050922	biological_process	negative regulation of chemotaxis
A	0051893	biological_process	regulation of focal adhesion assembly
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0071364	biological_process	cellular response to epidermal growth factor stimulus
A	0120183	biological_process	positive regulation of focal adhesion disassembly
A	1990264	biological_process	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
A	1990782	molecular_function	protein tyrosine kinase binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160

Chain	Residue	Details
A	SER124

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