1J2G

Crystal structure of Urate oxidase from Bacillus SP. TB-90 co-crystallized with 8-Azaxanthine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004846	molecular_function	urate oxidase activity
A	0006144	biological_process	purine nucleobase metabolic process
B	0004846	molecular_function	urate oxidase activity
B	0006144	biological_process	purine nucleobase metabolic process
C	0004846	molecular_function	urate oxidase activity
C	0006144	biological_process	purine nucleobase metabolic process
D	0004846	molecular_function	urate oxidase activity
D	0006144	biological_process	purine nucleobase metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	ARG298
D	ARG298

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	LYS106
A	ASP190
A	GLU191
A	HOH4349
B	LYS106

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 503

Chain	Residue
D	ARG133
D	ARG133
A	THR31
A	THR31

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	ARG298
C	ARG298

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AZA A 4320

Chain	Residue
A	PHE184
A	LEU195
A	ARG201
A	SER248
A	ILE249
A	GLN250
A	ASN276
A	HOH4388
B	TYR11
B	ALA72
B	THR73

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AZA B 1320

Chain	Residue
A	TYR11
A	ALA72
A	THR73
B	PHE184
B	LEU195
B	ARG201
B	SER248
B	ILE249
B	GLN250
B	ASN276
B	HOH1363

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE AZA C 2320

Chain	Residue
C	PHE184
C	ARG201
C	SER248
C	ILE249
C	GLN250
C	ASN276
C	HOH2419
D	TYR11
D	ALA72
D	THR73

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE AZA D 3320

Chain	Residue
C	THR73
D	PHE184
D	LEU195
D	ARG201
D	SER248
D	ILE249
D	GLN250
D	ASN276

---

Functional Information from PROSITE/UniProt

site_id	PS00366
Number of Residues	28
Details	URICASE Uricase signature. LqLIKVSgNsFvgFirdeYttLpedsnR

Chain	Residue	Details
A	LEU174-ARG201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Charge relay system; for urate oxidase activity => ECO:0000250|UniProtKB:D0VWQ1

Chain	Residue	Details
A	LYS13
A	THR73
B	LYS13
B	THR73
C	LYS13
C	THR73
D	LYS13
D	THR73

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system => ECO:0000250|UniProtKB:Q00511

Chain	Residue	Details
A	LYS24
B	LYS24
C	LYS24
D	LYS24

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q00511

Chain	Residue	Details
A	THR73
B	ASN276
C	THR73
C	ASP74
C	ILE249
C	GLN250
C	ASN276
D	THR73
D	ASP74
D	ILE249
D	GLN250
A	ASP74
D	ASN276
A	ILE249
A	GLN250
A	ASN276
B	THR73
B	ASP74
B	ILE249
B	GLN250

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|Ref.3

Chain	Residue	Details
A	PHE184
A	ARG201
B	PHE184
B	ARG201
C	PHE184
C	ARG201
D	PHE184
D	ARG201

---