1J2G
Crystal structure of Urate oxidase from Bacillus SP. TB-90 co-crystallized with 8-Azaxanthine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004846 | molecular_function | urate oxidase activity |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0004846 | molecular_function | urate oxidase activity |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| C | 0004846 | molecular_function | urate oxidase activity |
| C | 0006144 | biological_process | purine nucleobase metabolic process |
| D | 0004846 | molecular_function | urate oxidase activity |
| D | 0006144 | biological_process | purine nucleobase metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 501 |
| Chain | Residue |
| B | ARG298 |
| D | ARG298 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | LYS106 |
| A | ASP190 |
| A | GLU191 |
| A | HOH4349 |
| B | LYS106 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 503 |
| Chain | Residue |
| D | ARG133 |
| D | ARG133 |
| A | THR31 |
| A | THR31 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | ARG298 |
| C | ARG298 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AZA A 4320 |
| Chain | Residue |
| A | PHE184 |
| A | LEU195 |
| A | ARG201 |
| A | SER248 |
| A | ILE249 |
| A | GLN250 |
| A | ASN276 |
| A | HOH4388 |
| B | TYR11 |
| B | ALA72 |
| B | THR73 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE AZA B 1320 |
| Chain | Residue |
| A | TYR11 |
| A | ALA72 |
| A | THR73 |
| B | PHE184 |
| B | LEU195 |
| B | ARG201 |
| B | SER248 |
| B | ILE249 |
| B | GLN250 |
| B | ASN276 |
| B | HOH1363 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AZA C 2320 |
| Chain | Residue |
| C | PHE184 |
| C | ARG201 |
| C | SER248 |
| C | ILE249 |
| C | GLN250 |
| C | ASN276 |
| C | HOH2419 |
| D | TYR11 |
| D | ALA72 |
| D | THR73 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE AZA D 3320 |
| Chain | Residue |
| C | THR73 |
| D | PHE184 |
| D | LEU195 |
| D | ARG201 |
| D | SER248 |
| D | ILE249 |
| D | GLN250 |
| D | ASN276 |
Functional Information from PROSITE/UniProt
| site_id | PS00366 |
| Number of Residues | 28 |
| Details | URICASE Uricase signature. LqLIKVSgNsFvgFirdeYttLpedsnR |
| Chain | Residue | Details |
| A | LEU174-ARG201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Charge relay system; for urate oxidase activity","evidences":[{"source":"UniProtKB","id":"D0VWQ1","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00511","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of urate oxidase from Bacillus sp.","authoringGroup":["Mycobacterium tuberculosis structural genomics consortium (TB)"]}}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1r51 |
| Chain | Residue | Details |
| A | ARG201 | |
| A | GLN250 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1r51 |
| Chain | Residue | Details |
| B | ARG201 | |
| B | GLN250 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1r51 |
| Chain | Residue | Details |
| C | ARG201 | |
| C | GLN250 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1r51 |
| Chain | Residue | Details |
| D | ARG201 | |
| D | GLN250 |
