1J2F

X-ray crystal structure of IRF-3 and its functional implications

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: (Microbial infection) Phosphoserine => ECO:0000269|PubMed:24049179

Chain	Residue	Details
A	SER175
B	SER175

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site_id	SWS_FT_FI2
Number of Residues	10
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23746807

Chain	Residue	Details
A	THR180
B	THR404
A	THR237
A	THR244
A	THR253
A	THR404
B	THR180
B	THR237
B	THR244
B	THR253

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site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807

Chain	Residue	Details
A	SER188
A	SER398
A	SER427
B	SER188
B	SER398
B	SER427

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:22394562

Chain	Residue	Details
A	SER385
B	SER385

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579

Chain	Residue	Details
A	SER386
B	SER386

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine; by IKKE and TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579

Chain	Residue	Details
A	SER396
B	SER396

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site_id	SWS_FT_FI7
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:20308324

Chain	Residue	Details
A	LYS193
A	LYS360
A	LYS366
B	LYS193
B	LYS360
B	LYS366

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