1J2F
X-ray crystal structure of IRF-3 and its functional implications
Functional Information from GO Data
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: (Microbial infection) Phosphoserine => ECO:0000269|PubMed:24049179 |
| Chain | Residue | Details |
| A | SER175 | |
| B | SER175 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:23746807 |
| Chain | Residue | Details |
| A | THR180 | |
| B | THR404 | |
| A | THR237 | |
| A | THR244 | |
| A | THR253 | |
| A | THR404 | |
| B | THR180 | |
| B | THR237 | |
| B | THR244 | |
| B | THR253 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:23746807 |
| Chain | Residue | Details |
| A | SER188 | |
| A | SER398 | |
| A | SER427 | |
| B | SER188 | |
| B | SER398 | |
| B | SER427 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P70671 |
| Chain | Residue | Details |
| A | LYS366 | |
| B | LYS366 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:22394562 |
| Chain | Residue | Details |
| A | SER385 | |
| B | SER385 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23746807, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579 |
| Chain | Residue | Details |
| A | SER386 | |
| B | SER386 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by IKKE and TBK1 => ECO:0000269|PubMed:22394562, ECO:0000269|PubMed:23478265, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:36603579 |
| Chain | Residue | Details |
| A | SER396 | |
| B | SER396 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:20308324 |
| Chain | Residue | Details |
| A | LYS193 | |
| A | LYS360 | |
| A | LYS366 | |
| B | LYS193 | |
| B | LYS360 | |
| B | LYS366 |
