Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004818 | molecular_function | glutamate-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006424 | biological_process | glutamyl-tRNA aminoacylation |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016874 | molecular_function | ligase activity |
| A | 0043039 | biological_process | tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 502 |
| Chain | Residue |
| A | ATP501 |
| A | HOH1395 |
| A | HOH1396 |
| A | HOH1397 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU A 500 |
| Chain | Residue |
| A | ASN191 |
| A | ARG205 |
| A | TRP209 |
| A | ATP501 |
| A | HOH1021 |
| A | HOH1028 |
| A | HOH1138 |
| A | ARG5 |
| A | ALA7 |
| A | SER9 |
| A | GLU41 |
| A | TYR187 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ATP A 501 |
| Chain | Residue |
| A | HIS15 |
| A | GLU208 |
| A | TRP209 |
| A | LEU235 |
| A | LEU236 |
| A | LYS243 |
| A | ILE244 |
| A | SER245 |
| A | LYS246 |
| A | ARG247 |
| A | GLU500 |
| A | MG502 |
| A | HOH1037 |
| A | HOH1072 |
| A | HOH1085 |
| A | HOH1147 |
| A | HOH1185 |
| A | HOH1270 |
| A | HOH1359 |
| A | HOH1395 |
| A | HOH1396 |
| A | HOH1397 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PspTGdPHVGTA |
| Chain | Residue | Details |
| A | PRO8-ALA19 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | Region: {"description":"Interaction with tRNA"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Motif: {"description":"'HIGH' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00022","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"'KMSKS' region","evidences":[{"source":"HAMAP-Rule","id":"MF_00022","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 15 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00022","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interaction with tRNA; via carbonyl oxygen"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for discrimination between tRNA(Glu) and tRNA(Gln)"} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 12554668 |
| Chain | Residue | Details |
| A | LYS246 | |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 318 |
| Chain | Residue | Details |
| A | LYS246 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, increase nucleophilicity |
