1IZN

Crystal Structure of Actin Filament Capping Protein CapZ

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0008290	cellular_component	F-actin capping protein complex
A	0030018	cellular_component	Z disc
A	0030036	biological_process	actin cytoskeleton organization
A	0030863	cellular_component	cortical cytoskeleton
A	0034329	biological_process	cell junction assembly
A	0051015	molecular_function	actin filament binding
A	0051016	biological_process	barbed-end actin filament capping
A	0051693	biological_process	actin filament capping
A	0071203	cellular_component	WASH complex
B	0000902	biological_process	cell morphogenesis
B	0003779	molecular_function	actin binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005903	cellular_component	brush border
B	0008290	cellular_component	F-actin capping protein complex
B	0010591	biological_process	regulation of lamellipodium assembly
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0030018	cellular_component	Z disc
B	0030027	cellular_component	lamellipodium
B	0030036	biological_process	actin cytoskeleton organization
B	0030863	cellular_component	cortical cytoskeleton
B	0031674	cellular_component	I band
B	0051015	molecular_function	actin filament binding
B	0051016	biological_process	barbed-end actin filament capping
B	0051490	biological_process	negative regulation of filopodium assembly
B	0051693	biological_process	actin filament capping
B	0071203	cellular_component	WASH complex
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
B	0120212	cellular_component	sperm head-tail coupling apparatus
C	0003779	molecular_function	actin binding
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0008290	cellular_component	F-actin capping protein complex
C	0030018	cellular_component	Z disc
C	0030036	biological_process	actin cytoskeleton organization
C	0030863	cellular_component	cortical cytoskeleton
C	0034329	biological_process	cell junction assembly
C	0051015	molecular_function	actin filament binding
C	0051016	biological_process	barbed-end actin filament capping
C	0051693	biological_process	actin filament capping
C	0071203	cellular_component	WASH complex
D	0000902	biological_process	cell morphogenesis
D	0003779	molecular_function	actin binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005903	cellular_component	brush border
D	0008290	cellular_component	F-actin capping protein complex
D	0010591	biological_process	regulation of lamellipodium assembly
D	0014069	cellular_component	postsynaptic density
D	0016020	cellular_component	membrane
D	0030018	cellular_component	Z disc
D	0030027	cellular_component	lamellipodium
D	0030036	biological_process	actin cytoskeleton organization
D	0030863	cellular_component	cortical cytoskeleton
D	0031674	cellular_component	I band
D	0051015	molecular_function	actin filament binding
D	0051016	biological_process	barbed-end actin filament capping
D	0051490	biological_process	negative regulation of filopodium assembly
D	0051693	biological_process	actin filament capping
D	0071203	cellular_component	WASH complex
D	0098685	cellular_component	Schaffer collateral - CA1 synapse
D	0098686	cellular_component	hippocampal mossy fiber to CA3 synapse
D	0120212	cellular_component	sperm head-tail coupling apparatus

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 D 1001

Chain	Residue
B	LYS95
C	LEU275
D	LEU96
D	GLU99
D	PRO208
D	HIS209
D	ILE210
D	HOH1086

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NO3 B 1002

Chain	Residue
B	LEU96
B	GLU99
B	PRO208
B	HIS209
B	ILE210
B	HOH1080
D	LYS95
A	LEU275

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 B 1003

Chain	Residue
B	CYS62
B	ASP63
B	TYR71
B	LYS254
B	HOH1147

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NO3 D 1004

Chain	Residue
D	LEU40
D	GLN45
D	CYS62
D	ASP63
D	TYR71

---

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
B	CYS62-ASP67

---

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
A	VAL196-VAL204

---

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
A	LYS256-ARG266

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---