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1ITQ

HUMAN RENAL DIPEPTIDASE

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006629biological_processlipid metabolic process
A0006691biological_processleukotriene metabolic process
A0006749biological_processglutathione metabolic process
A0006751biological_processglutathione catabolic process
A0006954biological_processinflammatory response
A0008233molecular_functionpeptidase activity
A0008235molecular_functionmetalloexopeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0008800molecular_functionbeta-lactamase activity
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016787molecular_functionhydrolase activity
A0016805molecular_functiondipeptidase activity
A0016999biological_processantibiotic metabolic process
A0030054cellular_componentcell junction
A0030336biological_processnegative regulation of cell migration
A0030593biological_processneutrophil chemotaxis
A0031528cellular_componentmicrovillus membrane
A0034235molecular_functionGPI anchor binding
A0042995cellular_componentcell projection
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0045177cellular_componentapical part of cell
A0046872molecular_functionmetal ion binding
A0050667biological_processhomocysteine metabolic process
A0070062cellular_componentextracellular exosome
A0070573molecular_functionmetallodipeptidase activity
A0071277biological_processcellular response to calcium ion
A0071466biological_processcellular response to xenobiotic stimulus
A0071732biological_processcellular response to nitric oxide
A0072340biological_processlactam catabolic process
A0072341molecular_functionmodified amino acid binding
A0098552cellular_componentside of membrane
A1901749biological_processleukotriene D4 catabolic process
B0005515molecular_functionprotein binding
B0005615cellular_componentextracellular space
B0005654cellular_componentnucleoplasm
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006629biological_processlipid metabolic process
B0006691biological_processleukotriene metabolic process
B0006749biological_processglutathione metabolic process
B0006751biological_processglutathione catabolic process
B0006954biological_processinflammatory response
B0008233molecular_functionpeptidase activity
B0008235molecular_functionmetalloexopeptidase activity
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0008800molecular_functionbeta-lactamase activity
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0016787molecular_functionhydrolase activity
B0016805molecular_functiondipeptidase activity
B0016999biological_processantibiotic metabolic process
B0030054cellular_componentcell junction
B0030336biological_processnegative regulation of cell migration
B0030593biological_processneutrophil chemotaxis
B0031528cellular_componentmicrovillus membrane
B0034235molecular_functionGPI anchor binding
B0042995cellular_componentcell projection
B0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0045177cellular_componentapical part of cell
B0046872molecular_functionmetal ion binding
B0050667biological_processhomocysteine metabolic process
B0070062cellular_componentextracellular exosome
B0070573molecular_functionmetallodipeptidase activity
B0071277biological_processcellular response to calcium ion
B0071466biological_processcellular response to xenobiotic stimulus
B0071732biological_processcellular response to nitric oxide
B0072340biological_processlactam catabolic process
B0072341molecular_functionmodified amino acid binding
B0098552cellular_componentside of membrane
B1901749biological_processleukotriene D4 catabolic process
Functional Information from PROSITE/UniProt
site_idPS00869
Number of Residues23
DetailsRENAL_DIPEPTIDASE_1 Renal dipeptidase active site. VEGGhsIdsslgvLralYqlGMR
ChainResidueDetails
AVAL124-ARG146

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777
ChainResidueDetails
AHIS20
AASP22
AHIS198
AHIS219
BHIS20
BASP22
BHIS198
BHIS219

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10073, ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:32325220
ChainResidueDetails
AGLU125
BGLU125

site_idSWS_FT_FI3
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:12144777
ChainResidueDetails
AHIS152
AARG230
AASP288
BHIS152
BARG230
BASP288

site_idSWS_FT_FI4
Number of Residues2
DetailsLIPID: GPI-anchor amidated serine => ECO:0000269|PubMed:2168407
ChainResidueDetails
ASER369
BSER369

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777, ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN41
BASN41

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN263
BASN263

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12144777
ChainResidueDetails
AASN316
BASN316

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN342
BASN342

Catalytic Information from CSA
site_idMCSA1
Number of Residues7
DetailsM-CSA 168
ChainResidueDetails
AHIS20metal ligand
AASP22metal ligand
AGLU125metal ligand
AHIS152electrostatic stabiliser, hydrogen bond donor
AHIS198metal ligand
AHIS219metal ligand
AASP288hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_idMCSA2
Number of Residues7
DetailsM-CSA 168
ChainResidueDetails
BHIS20metal ligand
BASP22metal ligand
BGLU125metal ligand
BHIS152electrostatic stabiliser, hydrogen bond donor
BHIS198metal ligand
BHIS219metal ligand
BASP288hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

218853

PDB entries from 2024-04-24

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