1ITQ
HUMAN RENAL DIPEPTIDASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006691 | biological_process | leukotriene metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006751 | biological_process | glutathione catabolic process |
| A | 0006954 | biological_process | inflammatory response |
| A | 0008235 | molecular_function | metalloexopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016805 | molecular_function | dipeptidase activity |
| A | 0016999 | biological_process | antibiotic metabolic process |
| A | 0030054 | cellular_component | cell junction |
| A | 0030336 | biological_process | negative regulation of cell migration |
| A | 0030593 | biological_process | neutrophil chemotaxis |
| A | 0031528 | cellular_component | microvillus membrane |
| A | 0034235 | molecular_function | GPI anchor binding |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0050667 | biological_process | homocysteine metabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070573 | molecular_function | metallodipeptidase activity |
| A | 0071277 | biological_process | cellular response to calcium ion |
| A | 0071732 | biological_process | cellular response to nitric oxide |
| A | 0072340 | biological_process | lactam catabolic process |
| A | 0072341 | molecular_function | modified amino acid binding |
| A | 1901749 | biological_process | leukotriene D4 catabolic process |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006508 | biological_process | proteolysis |
| B | 0006691 | biological_process | leukotriene metabolic process |
| B | 0006749 | biological_process | glutathione metabolic process |
| B | 0006751 | biological_process | glutathione catabolic process |
| B | 0006954 | biological_process | inflammatory response |
| B | 0008235 | molecular_function | metalloexopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016805 | molecular_function | dipeptidase activity |
| B | 0016999 | biological_process | antibiotic metabolic process |
| B | 0030054 | cellular_component | cell junction |
| B | 0030336 | biological_process | negative regulation of cell migration |
| B | 0030593 | biological_process | neutrophil chemotaxis |
| B | 0031528 | cellular_component | microvillus membrane |
| B | 0034235 | molecular_function | GPI anchor binding |
| B | 0045177 | cellular_component | apical part of cell |
| B | 0050667 | biological_process | homocysteine metabolic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070573 | molecular_function | metallodipeptidase activity |
| B | 0071277 | biological_process | cellular response to calcium ion |
| B | 0071732 | biological_process | cellular response to nitric oxide |
| B | 0072340 | biological_process | lactam catabolic process |
| B | 0072341 | molecular_function | modified amino acid binding |
| B | 1901749 | biological_process | leukotriene D4 catabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00869 |
| Number of Residues | 23 |
| Details | RENAL_DIPEPTIDASE_1 Renal dipeptidase active site. VEGGhsIdsslgvLralYqlGMR |
| Chain | Residue | Details |
| A | VAL124-ARG146 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10073","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12144777","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10073","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12144777","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32325220","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12144777","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"GPI-anchor amidated serine","evidences":[{"source":"PubMed","id":"2168407","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12144777","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12144777","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 12144777 |
| Chain | Residue | Details |
| A | HIS152 | |
| A | ASP288 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 12144777 |
| Chain | Residue | Details |
| B | HIS152 | |
| B | ASP288 |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 168 |
| Chain | Residue | Details |
| A | HIS20 | metal ligand |
| A | ASP22 | metal ligand |
| A | GLU125 | metal ligand |
| A | HIS152 | electrostatic stabiliser, hydrogen bond donor |
| A | HIS198 | metal ligand |
| A | HIS219 | metal ligand |
| A | ASP288 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 168 |
| Chain | Residue | Details |
| B | HIS20 | metal ligand |
| B | ASP22 | metal ligand |
| B | GLU125 | metal ligand |
| B | HIS152 | electrostatic stabiliser, hydrogen bond donor |
| B | HIS198 | metal ligand |
| B | HIS219 | metal ligand |
| B | ASP288 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
