Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1IS7

Crystal structure of rat GTPCHI/GFRP stimulatory complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0003924	molecular_function	GTPase activity
A	0003934	molecular_function	GTP cyclohydrolase I activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0008217	biological_process	regulation of blood pressure
A	0008270	molecular_function	zinc ion binding
A	0010460	biological_process	positive regulation of heart rate
A	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
A	0014916	biological_process	regulation of lung blood pressure
A	0016787	molecular_function	hydrolase activity
A	0030742	molecular_function	GTP-dependent protein binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031965	cellular_component	nuclear membrane
A	0032212	biological_process	positive regulation of telomere maintenance via telomerase
A	0032496	biological_process	response to lipopolysaccharide
A	0032991	cellular_component	protein-containing complex
A	0034341	biological_process	response to type II interferon
A	0034612	biological_process	response to tumor necrosis factor
A	0042311	biological_process	vasodilation
A	0042416	biological_process	dopamine biosynthetic process
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0042559	biological_process	pteridine-containing compound biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0044877	molecular_function	protein-containing complex binding
A	0045776	biological_process	negative regulation of blood pressure
A	0046146	biological_process	tetrahydrobiopterin metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0048265	biological_process	response to pain
A	0050884	biological_process	neuromuscular process controlling posture
A	0051019	molecular_function	mitogen-activated protein kinase binding
A	0051066	biological_process	dihydrobiopterin metabolic process
A	0065003	biological_process	protein-containing complex assembly
A	0140535	cellular_component	intracellular protein-containing complex
A	2000121	biological_process	regulation of removal of superoxide radicals
A	2000773	biological_process	negative regulation of cellular senescence
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0003924	molecular_function	GTPase activity
B	0003934	molecular_function	GTP cyclohydrolase I activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0008217	biological_process	regulation of blood pressure
B	0008270	molecular_function	zinc ion binding
B	0010460	biological_process	positive regulation of heart rate
B	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
B	0014916	biological_process	regulation of lung blood pressure
B	0016787	molecular_function	hydrolase activity
B	0030742	molecular_function	GTP-dependent protein binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0031965	cellular_component	nuclear membrane
B	0032212	biological_process	positive regulation of telomere maintenance via telomerase
B	0032496	biological_process	response to lipopolysaccharide
B	0032991	cellular_component	protein-containing complex
B	0034341	biological_process	response to type II interferon
B	0034612	biological_process	response to tumor necrosis factor
B	0042311	biological_process	vasodilation
B	0042416	biological_process	dopamine biosynthetic process
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0042559	biological_process	pteridine-containing compound biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0044877	molecular_function	protein-containing complex binding
B	0045776	biological_process	negative regulation of blood pressure
B	0046146	biological_process	tetrahydrobiopterin metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0048265	biological_process	response to pain
B	0050884	biological_process	neuromuscular process controlling posture
B	0051019	molecular_function	mitogen-activated protein kinase binding
B	0051066	biological_process	dihydrobiopterin metabolic process
B	0065003	biological_process	protein-containing complex assembly
B	0140535	cellular_component	intracellular protein-containing complex
B	2000121	biological_process	regulation of removal of superoxide radicals
B	2000773	biological_process	negative regulation of cellular senescence
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0003924	molecular_function	GTPase activity
C	0003934	molecular_function	GTP cyclohydrolase I activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0008217	biological_process	regulation of blood pressure
C	0008270	molecular_function	zinc ion binding
C	0010460	biological_process	positive regulation of heart rate
C	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
C	0014916	biological_process	regulation of lung blood pressure
C	0016787	molecular_function	hydrolase activity
C	0030742	molecular_function	GTP-dependent protein binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031965	cellular_component	nuclear membrane
C	0032212	biological_process	positive regulation of telomere maintenance via telomerase
C	0032496	biological_process	response to lipopolysaccharide
C	0032991	cellular_component	protein-containing complex
C	0034341	biological_process	response to type II interferon
C	0034612	biological_process	response to tumor necrosis factor
C	0042311	biological_process	vasodilation
C	0042416	biological_process	dopamine biosynthetic process
C	0042558	biological_process	pteridine-containing compound metabolic process
C	0042559	biological_process	pteridine-containing compound biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0044877	molecular_function	protein-containing complex binding
C	0045776	biological_process	negative regulation of blood pressure
C	0046146	biological_process	tetrahydrobiopterin metabolic process
C	0046654	biological_process	tetrahydrofolate biosynthetic process
C	0046872	molecular_function	metal ion binding
C	0048265	biological_process	response to pain
C	0050884	biological_process	neuromuscular process controlling posture
C	0051019	molecular_function	mitogen-activated protein kinase binding
C	0051066	biological_process	dihydrobiopterin metabolic process
C	0065003	biological_process	protein-containing complex assembly
C	0140535	cellular_component	intracellular protein-containing complex
C	2000121	biological_process	regulation of removal of superoxide radicals
C	2000773	biological_process	negative regulation of cellular senescence
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0003924	molecular_function	GTPase activity
D	0003934	molecular_function	GTP cyclohydrolase I activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0008217	biological_process	regulation of blood pressure
D	0008270	molecular_function	zinc ion binding
D	0010460	biological_process	positive regulation of heart rate
D	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
D	0014916	biological_process	regulation of lung blood pressure
D	0016787	molecular_function	hydrolase activity
D	0030742	molecular_function	GTP-dependent protein binding
D	0031410	cellular_component	cytoplasmic vesicle
D	0031965	cellular_component	nuclear membrane
D	0032212	biological_process	positive regulation of telomere maintenance via telomerase
D	0032496	biological_process	response to lipopolysaccharide
D	0032991	cellular_component	protein-containing complex
D	0034341	biological_process	response to type II interferon
D	0034612	biological_process	response to tumor necrosis factor
D	0042311	biological_process	vasodilation
D	0042416	biological_process	dopamine biosynthetic process
D	0042558	biological_process	pteridine-containing compound metabolic process
D	0042559	biological_process	pteridine-containing compound biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043525	biological_process	positive regulation of neuron apoptotic process
D	0044877	molecular_function	protein-containing complex binding
D	0045776	biological_process	negative regulation of blood pressure
D	0046146	biological_process	tetrahydrobiopterin metabolic process
D	0046654	biological_process	tetrahydrofolate biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0048265	biological_process	response to pain
D	0050884	biological_process	neuromuscular process controlling posture
D	0051019	molecular_function	mitogen-activated protein kinase binding
D	0051066	biological_process	dihydrobiopterin metabolic process
D	0065003	biological_process	protein-containing complex assembly
D	0140535	cellular_component	intracellular protein-containing complex
D	2000121	biological_process	regulation of removal of superoxide radicals
D	2000773	biological_process	negative regulation of cellular senescence
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0003924	molecular_function	GTPase activity
E	0003934	molecular_function	GTP cyclohydrolase I activity
E	0005509	molecular_function	calcium ion binding
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0006729	biological_process	tetrahydrobiopterin biosynthetic process
E	0008217	biological_process	regulation of blood pressure
E	0008270	molecular_function	zinc ion binding
E	0010460	biological_process	positive regulation of heart rate
E	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
E	0014916	biological_process	regulation of lung blood pressure
E	0016787	molecular_function	hydrolase activity
E	0030742	molecular_function	GTP-dependent protein binding
E	0031410	cellular_component	cytoplasmic vesicle
E	0031965	cellular_component	nuclear membrane
E	0032212	biological_process	positive regulation of telomere maintenance via telomerase
E	0032496	biological_process	response to lipopolysaccharide
E	0032991	cellular_component	protein-containing complex
E	0034341	biological_process	response to type II interferon
E	0034612	biological_process	response to tumor necrosis factor
E	0042311	biological_process	vasodilation
E	0042416	biological_process	dopamine biosynthetic process
E	0042558	biological_process	pteridine-containing compound metabolic process
E	0042559	biological_process	pteridine-containing compound biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043525	biological_process	positive regulation of neuron apoptotic process
E	0044877	molecular_function	protein-containing complex binding
E	0045776	biological_process	negative regulation of blood pressure
E	0046146	biological_process	tetrahydrobiopterin metabolic process
E	0046654	biological_process	tetrahydrofolate biosynthetic process
E	0046872	molecular_function	metal ion binding
E	0048265	biological_process	response to pain
E	0050884	biological_process	neuromuscular process controlling posture
E	0051019	molecular_function	mitogen-activated protein kinase binding
E	0051066	biological_process	dihydrobiopterin metabolic process
E	0065003	biological_process	protein-containing complex assembly
E	0140535	cellular_component	intracellular protein-containing complex
E	2000121	biological_process	regulation of removal of superoxide radicals
E	2000773	biological_process	negative regulation of cellular senescence
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0003924	molecular_function	GTPase activity
F	0003934	molecular_function	GTP cyclohydrolase I activity
F	0005509	molecular_function	calcium ion binding
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006729	biological_process	tetrahydrobiopterin biosynthetic process
F	0008217	biological_process	regulation of blood pressure
F	0008270	molecular_function	zinc ion binding
F	0010460	biological_process	positive regulation of heart rate
F	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
F	0014916	biological_process	regulation of lung blood pressure
F	0016787	molecular_function	hydrolase activity
F	0030742	molecular_function	GTP-dependent protein binding
F	0031410	cellular_component	cytoplasmic vesicle
F	0031965	cellular_component	nuclear membrane
F	0032212	biological_process	positive regulation of telomere maintenance via telomerase
F	0032496	biological_process	response to lipopolysaccharide
F	0032991	cellular_component	protein-containing complex
F	0034341	biological_process	response to type II interferon
F	0034612	biological_process	response to tumor necrosis factor
F	0042311	biological_process	vasodilation
F	0042416	biological_process	dopamine biosynthetic process
F	0042558	biological_process	pteridine-containing compound metabolic process
F	0042559	biological_process	pteridine-containing compound biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043525	biological_process	positive regulation of neuron apoptotic process
F	0044877	molecular_function	protein-containing complex binding
F	0045776	biological_process	negative regulation of blood pressure
F	0046146	biological_process	tetrahydrobiopterin metabolic process
F	0046654	biological_process	tetrahydrofolate biosynthetic process
F	0046872	molecular_function	metal ion binding
F	0048265	biological_process	response to pain
F	0050884	biological_process	neuromuscular process controlling posture
F	0051019	molecular_function	mitogen-activated protein kinase binding
F	0051066	biological_process	dihydrobiopterin metabolic process
F	0065003	biological_process	protein-containing complex assembly
F	0140535	cellular_component	intracellular protein-containing complex
F	2000121	biological_process	regulation of removal of superoxide radicals
F	2000773	biological_process	negative regulation of cellular senescence
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0003924	molecular_function	GTPase activity
G	0003934	molecular_function	GTP cyclohydrolase I activity
G	0005509	molecular_function	calcium ion binding
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005829	cellular_component	cytosol
G	0006729	biological_process	tetrahydrobiopterin biosynthetic process
G	0008217	biological_process	regulation of blood pressure
G	0008270	molecular_function	zinc ion binding
G	0010460	biological_process	positive regulation of heart rate
G	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
G	0014916	biological_process	regulation of lung blood pressure
G	0016787	molecular_function	hydrolase activity
G	0030742	molecular_function	GTP-dependent protein binding
G	0031410	cellular_component	cytoplasmic vesicle
G	0031965	cellular_component	nuclear membrane
G	0032212	biological_process	positive regulation of telomere maintenance via telomerase
G	0032496	biological_process	response to lipopolysaccharide
G	0032991	cellular_component	protein-containing complex
G	0034341	biological_process	response to type II interferon
G	0034612	biological_process	response to tumor necrosis factor
G	0042311	biological_process	vasodilation
G	0042416	biological_process	dopamine biosynthetic process
G	0042558	biological_process	pteridine-containing compound metabolic process
G	0042559	biological_process	pteridine-containing compound biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043525	biological_process	positive regulation of neuron apoptotic process
G	0044877	molecular_function	protein-containing complex binding
G	0045776	biological_process	negative regulation of blood pressure
G	0046146	biological_process	tetrahydrobiopterin metabolic process
G	0046654	biological_process	tetrahydrofolate biosynthetic process
G	0046872	molecular_function	metal ion binding
G	0048265	biological_process	response to pain
G	0050884	biological_process	neuromuscular process controlling posture
G	0051019	molecular_function	mitogen-activated protein kinase binding
G	0051066	biological_process	dihydrobiopterin metabolic process
G	0065003	biological_process	protein-containing complex assembly
G	0140535	cellular_component	intracellular protein-containing complex
G	2000121	biological_process	regulation of removal of superoxide radicals
G	2000773	biological_process	negative regulation of cellular senescence
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0003924	molecular_function	GTPase activity
H	0003934	molecular_function	GTP cyclohydrolase I activity
H	0005509	molecular_function	calcium ion binding
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0006729	biological_process	tetrahydrobiopterin biosynthetic process
H	0008217	biological_process	regulation of blood pressure
H	0008270	molecular_function	zinc ion binding
H	0010460	biological_process	positive regulation of heart rate
H	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
H	0014916	biological_process	regulation of lung blood pressure
H	0016787	molecular_function	hydrolase activity
H	0030742	molecular_function	GTP-dependent protein binding
H	0031410	cellular_component	cytoplasmic vesicle
H	0031965	cellular_component	nuclear membrane
H	0032212	biological_process	positive regulation of telomere maintenance via telomerase
H	0032496	biological_process	response to lipopolysaccharide
H	0032991	cellular_component	protein-containing complex
H	0034341	biological_process	response to type II interferon
H	0034612	biological_process	response to tumor necrosis factor
H	0042311	biological_process	vasodilation
H	0042416	biological_process	dopamine biosynthetic process
H	0042558	biological_process	pteridine-containing compound metabolic process
H	0042559	biological_process	pteridine-containing compound biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043525	biological_process	positive regulation of neuron apoptotic process
H	0044877	molecular_function	protein-containing complex binding
H	0045776	biological_process	negative regulation of blood pressure
H	0046146	biological_process	tetrahydrobiopterin metabolic process
H	0046654	biological_process	tetrahydrofolate biosynthetic process
H	0046872	molecular_function	metal ion binding
H	0048265	biological_process	response to pain
H	0050884	biological_process	neuromuscular process controlling posture
H	0051019	molecular_function	mitogen-activated protein kinase binding
H	0051066	biological_process	dihydrobiopterin metabolic process
H	0065003	biological_process	protein-containing complex assembly
H	0140535	cellular_component	intracellular protein-containing complex
H	2000121	biological_process	regulation of removal of superoxide radicals
H	2000773	biological_process	negative regulation of cellular senescence
I	0000166	molecular_function	nucleotide binding
I	0003824	molecular_function	catalytic activity
I	0003924	molecular_function	GTPase activity
I	0003934	molecular_function	GTP cyclohydrolase I activity
I	0005509	molecular_function	calcium ion binding
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005829	cellular_component	cytosol
I	0006729	biological_process	tetrahydrobiopterin biosynthetic process
I	0008217	biological_process	regulation of blood pressure
I	0008270	molecular_function	zinc ion binding
I	0010460	biological_process	positive regulation of heart rate
I	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
I	0014916	biological_process	regulation of lung blood pressure
I	0016787	molecular_function	hydrolase activity
I	0030742	molecular_function	GTP-dependent protein binding
I	0031410	cellular_component	cytoplasmic vesicle
I	0031965	cellular_component	nuclear membrane
I	0032212	biological_process	positive regulation of telomere maintenance via telomerase
I	0032496	biological_process	response to lipopolysaccharide
I	0032991	cellular_component	protein-containing complex
I	0034341	biological_process	response to type II interferon
I	0034612	biological_process	response to tumor necrosis factor
I	0042311	biological_process	vasodilation
I	0042416	biological_process	dopamine biosynthetic process
I	0042558	biological_process	pteridine-containing compound metabolic process
I	0042559	biological_process	pteridine-containing compound biosynthetic process
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043525	biological_process	positive regulation of neuron apoptotic process
I	0044877	molecular_function	protein-containing complex binding
I	0045776	biological_process	negative regulation of blood pressure
I	0046146	biological_process	tetrahydrobiopterin metabolic process
I	0046654	biological_process	tetrahydrofolate biosynthetic process
I	0046872	molecular_function	metal ion binding
I	0048265	biological_process	response to pain
I	0050884	biological_process	neuromuscular process controlling posture
I	0051019	molecular_function	mitogen-activated protein kinase binding
I	0051066	biological_process	dihydrobiopterin metabolic process
I	0065003	biological_process	protein-containing complex assembly
I	0140535	cellular_component	intracellular protein-containing complex
I	2000121	biological_process	regulation of removal of superoxide radicals
I	2000773	biological_process	negative regulation of cellular senescence
J	0000166	molecular_function	nucleotide binding
J	0003824	molecular_function	catalytic activity
J	0003924	molecular_function	GTPase activity
J	0003934	molecular_function	GTP cyclohydrolase I activity
J	0005509	molecular_function	calcium ion binding
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005829	cellular_component	cytosol
J	0006729	biological_process	tetrahydrobiopterin biosynthetic process
J	0008217	biological_process	regulation of blood pressure
J	0008270	molecular_function	zinc ion binding
J	0010460	biological_process	positive regulation of heart rate
J	0010667	biological_process	negative regulation of cardiac muscle cell apoptotic process
J	0014916	biological_process	regulation of lung blood pressure
J	0016787	molecular_function	hydrolase activity
J	0030742	molecular_function	GTP-dependent protein binding
J	0031410	cellular_component	cytoplasmic vesicle
J	0031965	cellular_component	nuclear membrane
J	0032212	biological_process	positive regulation of telomere maintenance via telomerase
J	0032496	biological_process	response to lipopolysaccharide
J	0032991	cellular_component	protein-containing complex
J	0034341	biological_process	response to type II interferon
J	0034612	biological_process	response to tumor necrosis factor
J	0042311	biological_process	vasodilation
J	0042416	biological_process	dopamine biosynthetic process
J	0042558	biological_process	pteridine-containing compound metabolic process
J	0042559	biological_process	pteridine-containing compound biosynthetic process
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043525	biological_process	positive regulation of neuron apoptotic process
J	0044877	molecular_function	protein-containing complex binding
J	0045776	biological_process	negative regulation of blood pressure
J	0046146	biological_process	tetrahydrobiopterin metabolic process
J	0046654	biological_process	tetrahydrofolate biosynthetic process
J	0046872	molecular_function	metal ion binding
J	0048265	biological_process	response to pain
J	0050884	biological_process	neuromuscular process controlling posture
J	0051019	molecular_function	mitogen-activated protein kinase binding
J	0051066	biological_process	dihydrobiopterin metabolic process
J	0065003	biological_process	protein-containing complex assembly
J	0140535	cellular_component	intracellular protein-containing complex
J	2000121	biological_process	regulation of removal of superoxide radicals
J	2000773	biological_process	negative regulation of cellular senescence
K	0004857	molecular_function	enzyme inhibitor activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0009890	biological_process	negative regulation of biosynthetic process
K	0016597	molecular_function	amino acid binding
K	0030425	cellular_component	dendrite
K	0030742	molecular_function	GTP-dependent protein binding
K	0031965	cellular_component	nuclear membrane
K	0032991	cellular_component	protein-containing complex
K	0042470	cellular_component	melanosome
K	0042802	molecular_function	identical protein binding
K	0044549	molecular_function	GTP cyclohydrolase binding
K	0044877	molecular_function	protein-containing complex binding
K	0060308	molecular_function	GTP cyclohydrolase I regulator activity
K	0062014	biological_process	negative regulation of small molecule metabolic process
K	0065003	biological_process	protein-containing complex assembly
K	0140535	cellular_component	intracellular protein-containing complex
L	0004857	molecular_function	enzyme inhibitor activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0009890	biological_process	negative regulation of biosynthetic process
L	0016597	molecular_function	amino acid binding
L	0030425	cellular_component	dendrite
L	0030742	molecular_function	GTP-dependent protein binding
L	0031965	cellular_component	nuclear membrane
L	0032991	cellular_component	protein-containing complex
L	0042470	cellular_component	melanosome
L	0042802	molecular_function	identical protein binding
L	0044549	molecular_function	GTP cyclohydrolase binding
L	0044877	molecular_function	protein-containing complex binding
L	0060308	molecular_function	GTP cyclohydrolase I regulator activity
L	0062014	biological_process	negative regulation of small molecule metabolic process
L	0065003	biological_process	protein-containing complex assembly
L	0140535	cellular_component	intracellular protein-containing complex
M	0004857	molecular_function	enzyme inhibitor activity
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0009890	biological_process	negative regulation of biosynthetic process
M	0016597	molecular_function	amino acid binding
M	0030425	cellular_component	dendrite
M	0030742	molecular_function	GTP-dependent protein binding
M	0031965	cellular_component	nuclear membrane
M	0032991	cellular_component	protein-containing complex
M	0042470	cellular_component	melanosome
M	0042802	molecular_function	identical protein binding
M	0044549	molecular_function	GTP cyclohydrolase binding
M	0044877	molecular_function	protein-containing complex binding
M	0060308	molecular_function	GTP cyclohydrolase I regulator activity
M	0062014	biological_process	negative regulation of small molecule metabolic process
M	0065003	biological_process	protein-containing complex assembly
M	0140535	cellular_component	intracellular protein-containing complex
N	0004857	molecular_function	enzyme inhibitor activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0009890	biological_process	negative regulation of biosynthetic process
N	0016597	molecular_function	amino acid binding
N	0030425	cellular_component	dendrite
N	0030742	molecular_function	GTP-dependent protein binding
N	0031965	cellular_component	nuclear membrane
N	0032991	cellular_component	protein-containing complex
N	0042470	cellular_component	melanosome
N	0042802	molecular_function	identical protein binding
N	0044549	molecular_function	GTP cyclohydrolase binding
N	0044877	molecular_function	protein-containing complex binding
N	0060308	molecular_function	GTP cyclohydrolase I regulator activity
N	0062014	biological_process	negative regulation of small molecule metabolic process
N	0065003	biological_process	protein-containing complex assembly
N	0140535	cellular_component	intracellular protein-containing complex
O	0004857	molecular_function	enzyme inhibitor activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0009890	biological_process	negative regulation of biosynthetic process
O	0016597	molecular_function	amino acid binding
O	0030425	cellular_component	dendrite
O	0030742	molecular_function	GTP-dependent protein binding
O	0031965	cellular_component	nuclear membrane
O	0032991	cellular_component	protein-containing complex
O	0042470	cellular_component	melanosome
O	0042802	molecular_function	identical protein binding
O	0044549	molecular_function	GTP cyclohydrolase binding
O	0044877	molecular_function	protein-containing complex binding
O	0060308	molecular_function	GTP cyclohydrolase I regulator activity
O	0062014	biological_process	negative regulation of small molecule metabolic process
O	0065003	biological_process	protein-containing complex assembly
O	0140535	cellular_component	intracellular protein-containing complex
P	0004857	molecular_function	enzyme inhibitor activity
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0009890	biological_process	negative regulation of biosynthetic process
P	0016597	molecular_function	amino acid binding
P	0030425	cellular_component	dendrite
P	0030742	molecular_function	GTP-dependent protein binding
P	0031965	cellular_component	nuclear membrane
P	0032991	cellular_component	protein-containing complex
P	0042470	cellular_component	melanosome
P	0042802	molecular_function	identical protein binding
P	0044549	molecular_function	GTP cyclohydrolase binding
P	0044877	molecular_function	protein-containing complex binding
P	0060308	molecular_function	GTP cyclohydrolase I regulator activity
P	0062014	biological_process	negative regulation of small molecule metabolic process
P	0065003	biological_process	protein-containing complex assembly
P	0140535	cellular_component	intracellular protein-containing complex
Q	0004857	molecular_function	enzyme inhibitor activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0009890	biological_process	negative regulation of biosynthetic process
Q	0016597	molecular_function	amino acid binding
Q	0030425	cellular_component	dendrite
Q	0030742	molecular_function	GTP-dependent protein binding
Q	0031965	cellular_component	nuclear membrane
Q	0032991	cellular_component	protein-containing complex
Q	0042470	cellular_component	melanosome
Q	0042802	molecular_function	identical protein binding
Q	0044549	molecular_function	GTP cyclohydrolase binding
Q	0044877	molecular_function	protein-containing complex binding
Q	0060308	molecular_function	GTP cyclohydrolase I regulator activity
Q	0062014	biological_process	negative regulation of small molecule metabolic process
Q	0065003	biological_process	protein-containing complex assembly
Q	0140535	cellular_component	intracellular protein-containing complex
R	0004857	molecular_function	enzyme inhibitor activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0009890	biological_process	negative regulation of biosynthetic process
R	0016597	molecular_function	amino acid binding
R	0030425	cellular_component	dendrite
R	0030742	molecular_function	GTP-dependent protein binding
R	0031965	cellular_component	nuclear membrane
R	0032991	cellular_component	protein-containing complex
R	0042470	cellular_component	melanosome
R	0042802	molecular_function	identical protein binding
R	0044549	molecular_function	GTP cyclohydrolase binding
R	0044877	molecular_function	protein-containing complex binding
R	0060308	molecular_function	GTP cyclohydrolase I regulator activity
R	0062014	biological_process	negative regulation of small molecule metabolic process
R	0065003	biological_process	protein-containing complex assembly
R	0140535	cellular_component	intracellular protein-containing complex
S	0004857	molecular_function	enzyme inhibitor activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0009890	biological_process	negative regulation of biosynthetic process
S	0016597	molecular_function	amino acid binding
S	0030425	cellular_component	dendrite
S	0030742	molecular_function	GTP-dependent protein binding
S	0031965	cellular_component	nuclear membrane
S	0032991	cellular_component	protein-containing complex
S	0042470	cellular_component	melanosome
S	0042802	molecular_function	identical protein binding
S	0044549	molecular_function	GTP cyclohydrolase binding
S	0044877	molecular_function	protein-containing complex binding
S	0060308	molecular_function	GTP cyclohydrolase I regulator activity
S	0062014	biological_process	negative regulation of small molecule metabolic process
S	0065003	biological_process	protein-containing complex assembly
S	0140535	cellular_component	intracellular protein-containing complex
T	0004857	molecular_function	enzyme inhibitor activity
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0009890	biological_process	negative regulation of biosynthetic process
T	0016597	molecular_function	amino acid binding
T	0030425	cellular_component	dendrite
T	0030742	molecular_function	GTP-dependent protein binding
T	0031965	cellular_component	nuclear membrane
T	0032991	cellular_component	protein-containing complex
T	0042470	cellular_component	melanosome
T	0042802	molecular_function	identical protein binding
T	0044549	molecular_function	GTP cyclohydrolase binding
T	0044877	molecular_function	protein-containing complex binding
T	0060308	molecular_function	GTP cyclohydrolase I regulator activity
T	0062014	biological_process	negative regulation of small molecule metabolic process
T	0065003	biological_process	protein-containing complex assembly
T	0140535	cellular_component	intracellular protein-containing complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K R 2001

Chain	Residue
R	THR8
R	GLN9
R	ARG11
R	VAL14
R	GLY15

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K S 2002

Chain	Residue
S	GLY15
S	THR8
S	GLN9
S	ARG11
S	VAL14

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K T 2003

Chain	Residue
T	THR8
T	GLN9
T	ARG11
T	VAL14
T	GLY15

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K P 2004

Chain	Residue
P	THR8
P	GLN9
P	ARG11
P	VAL14
P	GLY15

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K Q 2005

Chain	Residue
Q	THR8
Q	GLN9
Q	ARG11
Q	VAL14
Q	GLY15

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K K 2006

Chain	Residue
K	THR8
K	GLN9
K	ARG11
K	VAL14
K	GLY15
K	HOH2008

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K L 2007

Chain	Residue
L	THR8
L	GLN9
L	ARG11
L	VAL14
L	GLY15
L	HOH2014

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K M 2008

Chain	Residue
M	THR8
M	GLN9
M	ARG11
M	VAL14
M	GLY15

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K N 2009

Chain	Residue
N	THR8
N	GLN9
N	ARG11
N	VAL14
N	GLY15
N	HOH2013

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K O 2010

Chain	Residue
O	THR8
O	GLN9
O	ARG11
O	VAL14
O	GLY15

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PHE R 1001

Chain	Residue
G	GLU227
G	PRO229
Q	ILE10
Q	GLN75
R	VAL73
R	GLY74
R	GLN75
R	THR76
R	HOH2003

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PHE R 1002

Chain	Residue
H	GLU227
R	ILE10
R	GLN75
R	LEU77
R	HOH2004
S	VAL73
S	GLY74
S	GLN75
S	THR76

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PHE P 1003

Chain	Residue
F	GLU227
F	PRO229
P	ILE10
P	GLN75
P	HOH2006
Q	VAL73
Q	GLN75
Q	THR76

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PHE S 1004

Chain	Residue
I	GLU227
I	PRO229
S	ILE10
S	GLN75
T	VAL73
T	GLN75
T	THR76

site_id	BC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PHE T 1005

Chain	Residue
J	GLU227
J	PRO229
P	VAL73
P	GLY74
P	GLN75
P	THR76
T	ILE10
T	ARG11
T	MET12
T	GLN75
T	HOH2008

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PHE M 1006

Chain	Residue
M	ILE10
M	ARG11
M	GLN75
N	VAL73
N	GLY74
N	GLN75
N	THR76
C	GLU227
C	PRO229

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PHE N 1007

Chain	Residue
D	GLU227
D	PRO229
N	ILE10
N	GLN75
O	VAL73
O	GLN75
O	THR76

site_id	BC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PHE O 1008

Chain	Residue
E	GLU227
E	PRO229
K	VAL73
K	GLY74
K	GLN75
K	THR76
O	ILE10
O	ARG11
O	GLN75
O	HOH2012

site_id	CC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PHE K 1009

Chain	Residue
A	GLU227
A	PRO229
K	GLN9
K	ILE10
K	ARG11
K	GLN75
K	LEU77
L	VAL73
L	GLN75
L	THR76

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PHE L 1010

Chain	Residue
B	GLU227
B	PRO229
L	GLN9
L	ILE10
L	ARG11
L	GLN75
M	VAL73
M	GLN75
M	THR76

Functional Information from PROSITE/UniProt

site_id	PS00859
Number of Residues	17
Details	GTP_CYCLOHYDROL_1_1 GTP cyclohydrolase I signature 1. EMVivKDIdmfSmCEHH

Chain	Residue	Details
A	GLU119-HIS135

site_id	PS00860
Number of Residues	11
Details	GTP_CYCLOHYDROL_1_2 GTP cyclohydrolase I signature 2. SrRlQVQERLT

Chain	Residue	Details
A	SER167-THR177

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P30793","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Site: {"description":"Involved in pterin ring binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P30793","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
A	HIS201
A	HIS134

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
J	HIS201
J	HIS134

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
B	HIS201
B	HIS134

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
C	HIS201
C	HIS134

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
D	HIS201
D	HIS134

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
E	HIS201
E	HIS134

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
F	HIS201
F	HIS134

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
G	HIS201
G	HIS134

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
H	HIS201
H	HIS134

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1gtp

Chain	Residue	Details
I	HIS201
I	HIS134

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)