Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1IRM

Crystal structure of apo heme oxygenase-1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001666	biological_process	response to hypoxia
A	0004392	molecular_function	heme oxygenase (decyclizing) activity
A	0004630	molecular_function	D-type glycerophospholipase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006644	biological_process	phospholipid metabolic process
A	0006788	biological_process	heme oxidation
A	0006979	biological_process	response to oxidative stress
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0008217	biological_process	regulation of blood pressure
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0009410	biological_process	response to xenobiotic stimulus
A	0010656	biological_process	negative regulation of muscle cell apoptotic process
A	0019899	molecular_function	enzyme binding
A	0020037	molecular_function	heme binding
A	0031670	biological_process	cellular response to nutrient
A	0032764	biological_process	negative regulation of mast cell cytokine production
A	0035556	biological_process	intracellular signal transduction
A	0042167	biological_process	heme catabolic process
A	0042542	biological_process	response to hydrogen peroxide
A	0043305	biological_process	negative regulation of mast cell degranulation
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0043627	biological_process	response to estrogen
A	0045766	biological_process	positive regulation of angiogenesis
A	0048662	biological_process	negative regulation of smooth muscle cell proliferation
A	0052869	molecular_function	arachidonate omega-hydroxylase activity
A	0097421	biological_process	liver regeneration
A	0110076	biological_process	negative regulation of ferroptosis
A	1904036	biological_process	negative regulation of epithelial cell apoptotic process
A	1904550	biological_process	response to arachidonate
A	1904681	biological_process	response to 3-methylcholanthrene
A	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
B	0001525	biological_process	angiogenesis
B	0001666	biological_process	response to hypoxia
B	0004392	molecular_function	heme oxygenase (decyclizing) activity
B	0004630	molecular_function	D-type glycerophospholipase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0005901	cellular_component	caveola
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006644	biological_process	phospholipid metabolic process
B	0006788	biological_process	heme oxidation
B	0006979	biological_process	response to oxidative stress
B	0007264	biological_process	small GTPase-mediated signal transduction
B	0008217	biological_process	regulation of blood pressure
B	0008285	biological_process	negative regulation of cell population proliferation
B	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
B	0009410	biological_process	response to xenobiotic stimulus
B	0010656	biological_process	negative regulation of muscle cell apoptotic process
B	0019899	molecular_function	enzyme binding
B	0020037	molecular_function	heme binding
B	0031670	biological_process	cellular response to nutrient
B	0032764	biological_process	negative regulation of mast cell cytokine production
B	0035556	biological_process	intracellular signal transduction
B	0042167	biological_process	heme catabolic process
B	0042542	biological_process	response to hydrogen peroxide
B	0043305	biological_process	negative regulation of mast cell degranulation
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0043627	biological_process	response to estrogen
B	0045766	biological_process	positive regulation of angiogenesis
B	0048662	biological_process	negative regulation of smooth muscle cell proliferation
B	0052869	molecular_function	arachidonate omega-hydroxylase activity
B	0097421	biological_process	liver regeneration
B	0110076	biological_process	negative regulation of ferroptosis
B	1904036	biological_process	negative regulation of epithelial cell apoptotic process
B	1904550	biological_process	response to arachidonate
B	1904681	biological_process	response to 3-methylcholanthrene
B	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
C	0001525	biological_process	angiogenesis
C	0001666	biological_process	response to hypoxia
C	0004392	molecular_function	heme oxygenase (decyclizing) activity
C	0004630	molecular_function	D-type glycerophospholipase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0005901	cellular_component	caveola
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006644	biological_process	phospholipid metabolic process
C	0006788	biological_process	heme oxidation
C	0006979	biological_process	response to oxidative stress
C	0007264	biological_process	small GTPase-mediated signal transduction
C	0008217	biological_process	regulation of blood pressure
C	0008285	biological_process	negative regulation of cell population proliferation
C	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
C	0009410	biological_process	response to xenobiotic stimulus
C	0010656	biological_process	negative regulation of muscle cell apoptotic process
C	0019899	molecular_function	enzyme binding
C	0020037	molecular_function	heme binding
C	0031670	biological_process	cellular response to nutrient
C	0032764	biological_process	negative regulation of mast cell cytokine production
C	0035556	biological_process	intracellular signal transduction
C	0042167	biological_process	heme catabolic process
C	0042542	biological_process	response to hydrogen peroxide
C	0043305	biological_process	negative regulation of mast cell degranulation
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0043627	biological_process	response to estrogen
C	0045766	biological_process	positive regulation of angiogenesis
C	0048662	biological_process	negative regulation of smooth muscle cell proliferation
C	0052869	molecular_function	arachidonate omega-hydroxylase activity
C	0097421	biological_process	liver regeneration
C	0110076	biological_process	negative regulation of ferroptosis
C	1904036	biological_process	negative regulation of epithelial cell apoptotic process
C	1904550	biological_process	response to arachidonate
C	1904681	biological_process	response to 3-methylcholanthrene
C	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00593
Number of Residues	11
Details	HEME_OXYGENASE Heme oxygenase signature. LVAHAYTRYLG

Chain	Residue	Details
C	LEU129-GLY139

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P09601","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Important for catalytic activity","evidences":[{"source":"UniProtKB","id":"P09601","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
C	ARG136
C	TYR58
C	THR135
C	GLY143
C	ASP140
C	GLY139

site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
A	ARG136
A	TYR58
A	THR135
A	GLY143
A	ASP140
A	GLY139

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
B	ARG136
B	TYR58
B	THR135
B	ASP140
B	GLY139

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
C	ASP140
C	GLY144

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
A	ASP140
A	GLY144

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1dve

Chain	Residue	Details
B	ASP140

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)