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1IRM

Crystal structure of apo heme oxygenase-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001666biological_processresponse to hypoxia
A0002246biological_processwound healing involved in inflammatory response
A0004392molecular_functionheme oxygenase (decyclizing) activity
A0004630molecular_functionphospholipase D activity
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005901cellular_componentcaveola
A0006357biological_processregulation of transcription by RNA polymerase II
A0006644biological_processphospholipid metabolic process
A0006788biological_processheme oxidation
A0006879biological_processintracellular iron ion homeostasis
A0006915biological_processapoptotic process
A0006979biological_processresponse to oxidative stress
A0007264biological_processsmall GTPase-mediated signal transduction
A0008217biological_processregulation of blood pressure
A0008285biological_processnegative regulation of cell population proliferation
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0009410biological_processresponse to xenobiotic stimulus
A0010656biological_processnegative regulation of muscle cell apoptotic process
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0016239biological_processpositive regulation of macroautophagy
A0016242biological_processnegative regulation of macroautophagy
A0016491molecular_functionoxidoreductase activity
A0019899molecular_functionenzyme binding
A0020037molecular_functionheme binding
A0031670biological_processcellular response to nutrient
A0032764biological_processnegative regulation of mast cell cytokine production
A0034101biological_processerythrocyte homeostasis
A0034605biological_processcellular response to heat
A0035094biological_processresponse to nicotine
A0035556biological_processintracellular signal transduction
A0042167biological_processheme catabolic process
A0042168biological_processheme metabolic process
A0042542biological_processresponse to hydrogen peroxide
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043305biological_processnegative regulation of mast cell degranulation
A0043524biological_processnegative regulation of neuron apoptotic process
A0043627biological_processresponse to estrogen
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0048662biological_processnegative regulation of smooth muscle cell proliferation
A0052869molecular_functionarachidonic acid omega-hydroxylase activity
A0060586biological_processmulticellular organismal-level iron ion homeostasis
A0071243biological_processcellular response to arsenic-containing substance
A0071276biological_processcellular response to cadmium ion
A0071456biological_processcellular response to hypoxia
A0072719biological_processcellular response to cisplatin
A0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
A0097421biological_processliver regeneration
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
A1904019biological_processepithelial cell apoptotic process
A1904036biological_processnegative regulation of epithelial cell apoptotic process
A1904037biological_processpositive regulation of epithelial cell apoptotic process
A1904550biological_processresponse to arachidonic acid
A1904681biological_processresponse to 3-methylcholanthrene
A1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
B0001525biological_processangiogenesis
B0001666biological_processresponse to hypoxia
B0002246biological_processwound healing involved in inflammatory response
B0004392molecular_functionheme oxygenase (decyclizing) activity
B0004630molecular_functionphospholipase D activity
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005901cellular_componentcaveola
B0006357biological_processregulation of transcription by RNA polymerase II
B0006644biological_processphospholipid metabolic process
B0006788biological_processheme oxidation
B0006879biological_processintracellular iron ion homeostasis
B0006915biological_processapoptotic process
B0006979biological_processresponse to oxidative stress
B0007264biological_processsmall GTPase-mediated signal transduction
B0008217biological_processregulation of blood pressure
B0008285biological_processnegative regulation of cell population proliferation
B0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
B0009410biological_processresponse to xenobiotic stimulus
B0010656biological_processnegative regulation of muscle cell apoptotic process
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0016239biological_processpositive regulation of macroautophagy
B0016242biological_processnegative regulation of macroautophagy
B0016491molecular_functionoxidoreductase activity
B0019899molecular_functionenzyme binding
B0020037molecular_functionheme binding
B0031670biological_processcellular response to nutrient
B0032764biological_processnegative regulation of mast cell cytokine production
B0034101biological_processerythrocyte homeostasis
B0034605biological_processcellular response to heat
B0035094biological_processresponse to nicotine
B0035556biological_processintracellular signal transduction
B0042167biological_processheme catabolic process
B0042168biological_processheme metabolic process
B0042542biological_processresponse to hydrogen peroxide
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043305biological_processnegative regulation of mast cell degranulation
B0043524biological_processnegative regulation of neuron apoptotic process
B0043627biological_processresponse to estrogen
B0045766biological_processpositive regulation of angiogenesis
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0048662biological_processnegative regulation of smooth muscle cell proliferation
B0052869molecular_functionarachidonic acid omega-hydroxylase activity
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0071243biological_processcellular response to arsenic-containing substance
B0071276biological_processcellular response to cadmium ion
B0071456biological_processcellular response to hypoxia
B0072719biological_processcellular response to cisplatin
B0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
B0097421biological_processliver regeneration
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
B1904019biological_processepithelial cell apoptotic process
B1904036biological_processnegative regulation of epithelial cell apoptotic process
B1904037biological_processpositive regulation of epithelial cell apoptotic process
B1904550biological_processresponse to arachidonic acid
B1904681biological_processresponse to 3-methylcholanthrene
B1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
C0001525biological_processangiogenesis
C0001666biological_processresponse to hypoxia
C0002246biological_processwound healing involved in inflammatory response
C0004392molecular_functionheme oxygenase (decyclizing) activity
C0004630molecular_functionphospholipase D activity
C0005198molecular_functionstructural molecule activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005901cellular_componentcaveola
C0006357biological_processregulation of transcription by RNA polymerase II
C0006644biological_processphospholipid metabolic process
C0006788biological_processheme oxidation
C0006879biological_processintracellular iron ion homeostasis
C0006915biological_processapoptotic process
C0006979biological_processresponse to oxidative stress
C0007264biological_processsmall GTPase-mediated signal transduction
C0008217biological_processregulation of blood pressure
C0008285biological_processnegative regulation of cell population proliferation
C0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
C0009410biological_processresponse to xenobiotic stimulus
C0010656biological_processnegative regulation of muscle cell apoptotic process
C0016020cellular_componentmembrane
C0016236biological_processmacroautophagy
C0016239biological_processpositive regulation of macroautophagy
C0016242biological_processnegative regulation of macroautophagy
C0016491molecular_functionoxidoreductase activity
C0019899molecular_functionenzyme binding
C0020037molecular_functionheme binding
C0031670biological_processcellular response to nutrient
C0032764biological_processnegative regulation of mast cell cytokine production
C0034101biological_processerythrocyte homeostasis
C0034605biological_processcellular response to heat
C0035094biological_processresponse to nicotine
C0035556biological_processintracellular signal transduction
C0042167biological_processheme catabolic process
C0042168biological_processheme metabolic process
C0042542biological_processresponse to hydrogen peroxide
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043305biological_processnegative regulation of mast cell degranulation
C0043524biological_processnegative regulation of neuron apoptotic process
C0043627biological_processresponse to estrogen
C0045766biological_processpositive regulation of angiogenesis
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0048662biological_processnegative regulation of smooth muscle cell proliferation
C0052869molecular_functionarachidonic acid omega-hydroxylase activity
C0060586biological_processmulticellular organismal-level iron ion homeostasis
C0071243biological_processcellular response to arsenic-containing substance
C0071276biological_processcellular response to cadmium ion
C0071456biological_processcellular response to hypoxia
C0072719biological_processcellular response to cisplatin
C0090050biological_processpositive regulation of cell migration involved in sprouting angiogenesis
C0097421biological_processliver regeneration
C1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
C1903589biological_processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
C1904019biological_processepithelial cell apoptotic process
C1904036biological_processnegative regulation of epithelial cell apoptotic process
C1904037biological_processpositive regulation of epithelial cell apoptotic process
C1904550biological_processresponse to arachidonic acid
C1904681biological_processresponse to 3-methylcholanthrene
C1904706biological_processnegative regulation of vascular associated smooth muscle cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00593
Number of Residues11
DetailsHEME_OXYGENASE Heme oxygenase signature. LVAHAYTRYLG
ChainResidueDetails
CLEU129-GLY139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues795
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
CMET1-THR266
AMET1-THR266
BMET1-THR266

site_idSWS_FT_FI2
Number of Residues9
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
CLYS18
CTYR134
CARG183
ALYS18
ATYR134
AARG183
BLYS18
BTYR134
BARG183

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
CHIS25
AHIS25
BHIS25

site_idSWS_FT_FI4
Number of Residues3
DetailsSITE: Important for catalytic activity => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
CASP140
AASP140
BASP140

site_idSWS_FT_FI5
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P09601
ChainResidueDetails
CSER229
ASER229
BSER229

site_idSWS_FT_FI6
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
CSER242
ASER242
BSER242

218853

PDB entries from 2024-04-24

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