1ING

INFLUENZA A SUBTYPE N2 NEURAMINIDASE COMPLEXED WITH AROMATIC BANA109 INHIBITOR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004308	molecular_function	exo-alpha-sialidase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0016020	cellular_component	membrane
A	0033644	cellular_component	host cell membrane
A	0046761	biological_process	viral budding from plasma membrane
A	0055036	cellular_component	virion membrane
B	0004308	molecular_function	exo-alpha-sialidase activity
B	0005975	biological_process	carbohydrate metabolic process
B	0016020	cellular_component	membrane
B	0033644	cellular_component	host cell membrane
B	0046761	biological_process	viral budding from plasma membrane
B	0055036	cellular_component	virion membrane

Functional Information from PDB Data

site_id	CAA
Number of Residues	11
Details	SUBSTRATE (SIALIC ACID) BINDING RESIDUES CATALYTIC SITE IN CHAIN A

Chain	Residue
A	ARG118
A	ARG371
A	TYR406
A	GLU119
A	ASP151
A	ARG152
A	TRP178
A	ILE222
A	ARG224
A	GLU276
A	ARG292

---

site_id	CAB
Number of Residues	11
Details	SUBSTRATE (SIALIC ACID) BINDING RESIDUES CATALYTIC SITE IN CHAIN B

Chain	Residue
B	ARG118
B	GLU119
B	ASP151
B	ARG152
B	TRP178
B	ILE222
B	ARG224
B	GLU276
B	ARG292
B	ARG371
B	TYR406

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Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CsCypRypGVrC

Chain	Residue	Details
A	CYS278-CYS289

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASP151
B	ASP151

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	TYR406
B	TYR406

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ARG118
B	ARG371
A	ARG152
A	GLU276
A	ARG292
A	ARG371
B	ARG118
B	ARG152
B	GLU276
B	ARG292

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:1920428, ECO:0000269|PubMed:7844831, ECO:0000269|PubMed:7880809

Chain	Residue	Details
A	ASP293
B	THR346
A	GLY297
A	ASP324
A	GLY345
A	THR346
B	ASP293
B	GLY297
B	ASP324
B	GLY345

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:1920428, ECO:0000269|PubMed:7844831, ECO:0000269|PubMed:7880809

Chain	Residue	Details
A	GLN347
B	GLN347

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:1920428, ECO:0000269|PubMed:7844831, ECO:0000269|PubMed:7880809

Chain	Residue	Details
A	ASN86
B	ASN86

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:1920428, ECO:0000269|PubMed:7844831, ECO:0000269|PubMed:7880809

Chain	Residue	Details
A	ASN146
A	ASN200
B	ASN146
B	ASN200

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071, ECO:0000269|PubMed:7844831, ECO:0000269|PubMed:7880809

Chain	Residue	Details
A	ASN234
B	ASN234

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASN402
B	ASN402

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a4g

Chain	Residue	Details
A	ASP151
A	GLU277

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a4g

Chain	Residue	Details
B	ASP151
B	GLU277

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