1ILE
ISOLEUCYL-TRNA SYNTHETASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004822 | molecular_function | isoleucine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006428 | biological_process | isoleucyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1101 |
| Chain | Residue |
| A | CYS181 |
| A | CYS184 |
| A | CYS389 |
| A | CYS392 |
| A | HOH1327 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1102 |
| Chain | Residue |
| A | HOH1179 |
| A | CYS461 |
| A | CYS464 |
| A | CYS502 |
| A | CYS504 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PtaNGlPHVGHA |
| Chain | Residue | Details |
| A | PRO47-ALA58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:11584022, ECO:0007744|PDB:1JZQ |
| Chain | Residue | Details |
| A | PRO46 | |
| A | HIS57 | |
| A | GLU550 | |
| A | GLY551 | |
| A | ASP553 | |
| A | GLN554 | |
| A | HIS581 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1ILE, ECO:0007744|PDB:1JZQ, ECO:0007744|PDB:1JZS |
| Chain | Residue | Details |
| A | CYS181 | |
| A | CYS184 | |
| A | CYS389 | |
| A | CYS392 | |
| A | CYS502 | |
| A | CYS504 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14672940 |
| Chain | Residue | Details |
| A | HIS319 | |
| A | ASP328 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1ILE, ECO:0007744|PDB:1JZQ |
| Chain | Residue | Details |
| A | CYS461 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1ILE |
| Chain | Residue | Details |
| A | CYS464 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS594 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 309 |
| Chain | Residue | Details |
| A | PRO46 | steric role, van der waals interaction |
| A | ASP85 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond acceptor, steric role |
| A | TRP518 | steric role, van der waals interaction |
| A | GLN554 | hydrogen bond acceptor, steric role |
| A | TRP558 | steric role, van der waals interaction |
| A | LYS591 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor |
| A | LYS594 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor |
