1IJE
Nucleotide Exchange Intermediates in the eEF1A-eEF1Ba Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000329 | cellular_component | fungal-type vacuole membrane |
| A | 0001933 | biological_process | negative regulation of protein phosphorylation |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003779 | molecular_function | actin binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005840 | cellular_component | ribosome |
| A | 0005853 | cellular_component | eukaryotic translation elongation factor 1 complex |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0006409 | biological_process | tRNA export from nucleus |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0006417 | biological_process | regulation of translation |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0019003 | molecular_function | GDP binding |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0034198 | biological_process | cellular response to amino acid starvation |
| A | 0043022 | molecular_function | ribosome binding |
| A | 0051015 | molecular_function | actin filament binding |
| A | 0051017 | biological_process | actin filament bundle assembly |
| A | 1904408 | molecular_function | melatonin binding |
| B | 0003746 | molecular_function | translation elongation factor activity |
| B | 0005853 | cellular_component | eukaryotic translation elongation factor 1 complex |
| B | 0006414 | biological_process | translational elongation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GDP A 507 |
| Chain | Residue |
| A | GLY19 |
| A | TRP194 |
| A | HOH525 |
| A | HOH574 |
| A | LYS20 |
| A | SER21 |
| A | THR22 |
| A | ASN153 |
| A | LYS154 |
| A | ASP156 |
| A | SER192 |
| A | GLY193 |
Functional Information from PROSITE/UniProt
| site_id | PS00301 |
| Number of Residues | 16 |
| Details | G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DKlkaEReRGITIdiA |
| Chain | Residue | Details |
| A | ASP61-ALA76 |
| site_id | PS00825 |
| Number of Residues | 12 |
| Details | EF1BD_2 Elongation factor 1 beta/beta'/delta chain signature 2. VQStDIaAMQKL |
| Chain | Residue | Details |
| B | VAL1195-LEU1206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | GLY14 | |
| A | ASP91 | |
| A | ASN153 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Not modified |
| Chain | Residue | Details |
| A | GLU298 | |
| A | GLU372 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N,N,N-trimethylglycine; by EFM7 => ECO:0000269|PubMed:26545399 |
| Chain | Residue | Details |
| A | GLY2 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; by EFM7; alternate => ECO:0000269|PubMed:26545399 |
| Chain | Residue | Details |
| A | LYS3 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:17287358 |
| Chain | Residue | Details |
| A | SER18 | |
| A | SER163 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; by EFM1 => ECO:0000269|PubMed:22522802, ECO:0000269|PubMed:24517342, ECO:0000269|PubMed:8476932 |
| Chain | Residue | Details |
| A | LYS30 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17287358 |
| Chain | Residue | Details |
| A | THR72 | |
| A | THR82 | |
| A | THR430 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6,N6,N6-trimethyllysine; by EFM5 => ECO:0000269|PubMed:22522802, ECO:0000269|PubMed:24517342, ECO:0000269|PubMed:25446118, ECO:0000269|PubMed:8476932 |
| Chain | Residue | Details |
| A | LYS79 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | THR259 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| A | SER289 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; by EFM4; alternate => ECO:0000269|PubMed:24517342 |
| Chain | Residue | Details |
| A | LYS316 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; by EFM6 => ECO:0000269|PubMed:22522802, ECO:0000269|PubMed:24517342, ECO:0000269|PubMed:26115316, ECO:0000269|PubMed:8476932 |
| Chain | Residue | Details |
| A | LYS390 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956 |
| Chain | Residue | Details |
| A | SER414 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Lysine methyl ester => ECO:0000269|PubMed:10973948 |
| Chain | Residue | Details |
| A | LYS458 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 7 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS224 | |
| A | LYS242 | |
| A | LYS253 | |
| A | LYS271 | |
| A | LYS393 | |
| A | LYS437 |
