1IFA

THREE-DIMENSIONAL CRYSTAL STRUCTURE OF RECOMBINANT MURINE INTERFERON-BETA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0002281	biological_process	macrophage activation involved in immune response
A	0002286	biological_process	T cell activation involved in immune response
A	0002312	biological_process	B cell activation involved in immune response
A	0002323	biological_process	natural killer cell activation involved in immune response
A	0002638	biological_process	negative regulation of immunoglobulin production
A	0002683	biological_process	negative regulation of immune system process
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005132	molecular_function	type I interferon receptor binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006952	biological_process	defense response
A	0006955	biological_process	immune response
A	0006959	biological_process	humoral immune response
A	0007165	biological_process	signal transduction
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0008285	biological_process	negative regulation of cell population proliferation
A	0008811	molecular_function	chloramphenicol O-acetyltransferase activity
A	0009893	biological_process	positive regulation of metabolic process
A	0010508	biological_process	positive regulation of autophagy
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0032689	biological_process	negative regulation of type II interferon production
A	0035458	biological_process	cellular response to interferon-beta
A	0042100	biological_process	B cell proliferation
A	0042742	biological_process	defense response to bacterium
A	0043330	biological_process	response to exogenous dsRNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0045087	biological_process	innate immune response
A	0045321	biological_process	leukocyte activation
A	0045581	biological_process	negative regulation of T cell differentiation
A	0045671	biological_process	negative regulation of osteoclast differentiation
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051241	biological_process	negative regulation of multicellular organismal process
A	0051607	biological_process	defense response to virus
A	0060337	biological_process	type I interferon-mediated signaling pathway
A	0060354	biological_process	negative regulation of cell adhesion molecule production
A	0070050	biological_process	neuron cellular homeostasis
A	0071359	biological_process	cellular response to dsRNA
A	0071549	biological_process	cellular response to dexamethasone stimulus
A	0071636	biological_process	positive regulation of transforming growth factor beta production
A	0071676	biological_process	negative regulation of mononuclear cell migration
A	0097696	biological_process	cell surface receptor signaling pathway via STAT
A	0098586	biological_process	cellular response to virus
A	0140123	biological_process	negative regulation of Lewy body formation
A	0140374	biological_process	antiviral innate immune response
A	0150079	biological_process	negative regulation of neuroinflammatory response
A	1900182	biological_process	positive regulation of protein localization to nucleus
A	1904465	biological_process	negative regulation of matrix metallopeptidase secretion
A	1905604	biological_process	negative regulation of blood-brain barrier permeability
A	2000552	biological_process	negative regulation of T-helper 2 cell cytokine production
A	2001235	biological_process	positive regulation of apoptotic signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00252
Number of Residues	19
Details	INTERFERON_A_B_D Interferon alpha, beta and delta family signature. YYwRVqrYLklmkynsYAW

Chain	Residue	Details
A	TYR120-TRP138

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P70499","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3360010","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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