1IE4

RAT TRANSTHYRETIN COMPLEX WITH THYROXINE (T4)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006144	biological_process	purine nucleobase metabolic process
A	0007165	biological_process	signal transduction
A	0032991	cellular_component	protein-containing complex
A	0042403	biological_process	thyroid hormone metabolic process
A	0042562	molecular_function	hormone binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0070324	molecular_function	thyroid hormone binding
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006144	biological_process	purine nucleobase metabolic process
B	0007165	biological_process	signal transduction
B	0032991	cellular_component	protein-containing complex
B	0042403	biological_process	thyroid hormone metabolic process
B	0042562	molecular_function	hormone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0070324	molecular_function	thyroid hormone binding
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006144	biological_process	purine nucleobase metabolic process
C	0007165	biological_process	signal transduction
C	0032991	cellular_component	protein-containing complex
C	0042403	biological_process	thyroid hormone metabolic process
C	0042562	molecular_function	hormone binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0070324	molecular_function	thyroid hormone binding
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006144	biological_process	purine nucleobase metabolic process
D	0007165	biological_process	signal transduction
D	0032991	cellular_component	protein-containing complex
D	0042403	biological_process	thyroid hormone metabolic process
D	0042562	molecular_function	hormone binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0070324	molecular_function	thyroid hormone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE T44 A 128

Chain	Residue
A	LYS15
C	HOH1131
A	LEU17
A	GLU54
A	ALA109
A	LEU110
A	HOH1079
C	LYS15
C	GLU54
C	ALA108

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site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE T44 B 328

Chain	Residue
B	LYS15
B	GLU54
B	ALA108
B	ALA109
B	LEU110
B	HOH1076
B	HOH1085
B	HOH1133
B	HOH1134
D	LYS15
D	ALA108
D	ALA109
D	HOH1132

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Functional Information from PROSITE/UniProt

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAvdVaV

Chain	Residue	Details
A	LYS15-VAL30

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site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000305|PubMed:11995998, ECO:0007744|PDB:1KGI

Chain	Residue	Details
A	LYS15
A	SER117
B	LYS15
B	SER117
C	LYS15
C	SER117
D	LYS15
D	SER117

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:11995998

Chain	Residue	Details
A	GLU54
B	GLU54
C	GLU54
D	GLU54

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Sulfocysteine => ECO:0000250|UniProtKB:P02766

Chain	Residue	Details
A	CYS10
B	CYS10
C	CYS10
D	CYS10

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: 4-carboxyglutamate => ECO:0000250|UniProtKB:P02766

Chain	Residue	Details
A	GLU42
B	GLU42
C	GLU42
D	GLU42

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
A	SER52
B	SER52
C	SER52
D	SER52

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN98
B	ASN98
C	ASN98
D	ASN98

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