1I8L
HUMAN B7-1/CTLA-4 CO-STIMULATORY COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015026 | molecular_function | coreceptor activity |
| A | 0031295 | biological_process | T cell costimulation |
| B | 0015026 | molecular_function | coreceptor activity |
| B | 0031295 | biological_process | T cell costimulation |
| C | 0006955 | biological_process | immune response |
| C | 0016020 | cellular_component | membrane |
| C | 0042129 | biological_process | regulation of T cell proliferation |
| D | 0006955 | biological_process | immune response |
| D | 0016020 | cellular_component | membrane |
| D | 0042129 | biological_process | regulation of T cell proliferation |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 402 |
| Details | Domain: {"description":"Ig-like V-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 170 |
| Details | Domain: {"description":"Ig-like C2-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Region: {"description":"Homodimerization","evidences":[{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | Region: {"description":"Important for interaction with CD80 and CD86","evidences":[{"source":"PubMed","id":"28484017","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Region: {"description":"Homodimerization","evidences":[{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28484017","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21156796","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11279502","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
