1I7Q
ANTHRANILATE SYNTHASE FROM S. MARCESCENS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004049 | molecular_function | anthranilate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0002047 | biological_process | phenazine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| B | 0004049 | molecular_function | anthranilate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004049 | molecular_function | anthranilate synthase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0002047 | biological_process | phenazine biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004048 | molecular_function | anthranilate phosphoribosyltransferase activity |
| D | 0004049 | molecular_function | anthranilate synthase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1701 |
| Chain | Residue |
| A | GLU361 |
| A | GLU498 |
| A | BEZ1501 |
| A | HOH1760 |
| A | HOH1898 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 1702 |
| Chain | Residue |
| C | HOH1719 |
| C | GLU361 |
| C | GLU498 |
| C | BEZ1502 |
| C | HOH1716 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GLU B 1401 |
| Chain | Residue |
| A | GLY259 |
| B | PRO57 |
| B | GLY58 |
| B | PRO59 |
| B | GLY60 |
| B | CYS85 |
| B | LEU86 |
| B | GLN89 |
| B | TYR133 |
| B | HIS134 |
| B | SER135 |
| B | LEU136 |
| B | HOH1547 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU D 1402 |
| Chain | Residue |
| C | GLY259 |
| D | PRO57 |
| D | GLY58 |
| D | PRO59 |
| D | GLY60 |
| D | CYS85 |
| D | LEU86 |
| D | GLN89 |
| D | TYR133 |
| D | HIS134 |
| D | SER135 |
| D | LEU136 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BEZ A 1501 |
| Chain | Residue |
| A | GLU309 |
| A | ILE326 |
| A | GLY328 |
| A | THR329 |
| A | GLU361 |
| A | THR425 |
| A | ARG469 |
| A | ALA484 |
| A | GLY485 |
| A | GLU498 |
| A | LYS502 |
| A | PYR1601 |
| A | MG1701 |
| A | HOH1881 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BEZ C 1502 |
| Chain | Residue |
| C | GLU309 |
| C | ILE326 |
| C | GLY328 |
| C | THR329 |
| C | GLU361 |
| C | HIS398 |
| C | THR425 |
| C | ARG469 |
| C | GLY485 |
| C | GLU498 |
| C | LYS502 |
| C | PYR1602 |
| C | MG1702 |
| C | HOH1922 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PYR A 1601 |
| Chain | Residue |
| A | TYR449 |
| A | ILE468 |
| A | ARG469 |
| A | ALA482 |
| A | GLY483 |
| A | LYS502 |
| A | BEZ1501 |
| A | HOH1702 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PYR C 1602 |
| Chain | Residue |
| C | VAL265 |
| C | TYR449 |
| C | ILE468 |
| C | ARG469 |
| C | ALA482 |
| C | GLY483 |
| C | LYS502 |
| C | BEZ1502 |
| C | HOH1711 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1I7S","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 380 |
| Details | Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00605","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for GATase activity","evidences":[{"source":"PubMed","id":"11371633","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Active site: {"description":"For GATase activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00605","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | a catalytic site defined by CSA, PubMed 11371633 |
| Chain | Residue | Details |
| A | HIS398 | |
| B | CYS85 | |
| B | HIS172 | |
| B | GLU174 |
